UniProtKB - P0ABM1 (CCMC_ECOLI)
Protein
Heme exporter protein C
Gene
ccmC
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
GO - Molecular functioni
- heme binding Source: InterPro
- heme transmembrane transporter activity Source: InterPro
GO - Biological processi
- cytochrome complex assembly Source: UniProtKB-KW
- heme transport Source: GO_Central
Keywordsi
Biological process | Cytochrome c-type biogenesis, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:CCMC-MONOMER MetaCyc:CCMC-MONOMER |
Protein family/group databases
TCDBi | 9.B.14.2.3, the putative heme handling protein (hhp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Heme exporter protein CAlternative name(s): Cytochrome c-type biogenesis protein CcmC |
Gene namesi | Name:ccmC Synonyms:yejT, yejU Ordered Locus Names:b2199, JW2187 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 42 – 63 | PeriplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 90 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 91 – 111 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 112 – 128 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 150 – 159 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 181 – 205 | PeriplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 245 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201551 | 1 – 245 | Heme exporter protein CAdd BLAST | 245 |
Proteomic databases
PaxDbi | P0ABM1 |
PRIDEi | P0ABM1 |
Interactioni
Binary interactionsi
Hide detailsP0ABM1
With | #Exp. | IntAct |
---|---|---|
ccmA [P33931] | 4 | EBI-2123469,EBI-6402796 |
ccmD [P0ABM5] | 4 | EBI-2123469,EBI-3894922 |
ccmE [P69490] | 7 | EBI-2123469,EBI-1128007 |
Protein-protein interaction databases
BioGRIDi | 4263174, 20 interactors 851044, 1 interactor |
ComplexPortali | CPX-3568, CcmABCDE system I cytochrome c biogenesis complex |
IntActi | P0ABM1, 4 interactors |
MINTi | P0ABM1 |
STRINGi | 511145.b2199 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CcmC/CycZ/HelC family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0755, Bacteria |
HOGENOMi | CLU_066538_2_0_6 |
InParanoidi | P0ABM1 |
PhylomeDBi | P0ABM1 |
Family and domain databases
InterProi | View protein in InterPro IPR002541, Cyt_c_assembly IPR003557, Cyt_c_biogenesis_CcmC |
Pfami | View protein in Pfam PF01578, Cytochrom_C_asm, 1 hit |
PRINTSi | PR01386, CCMCBIOGNSIS |
TIGRFAMsi | TIGR01191, ccmC, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ABM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWKTLHQLAI PPRLYQICGW FIPWLAIASV VVLTVGWIWG FGFAPADYQQ
60 70 80 90 100
GNSYRIIYLH VPAAIWSMGI YASMAVAAFI GLVWQMKMAN LAVAAMAPIG
110 120 130 140 150
AVFTFIALVT GSAWGKPMWG TWWVWDARLT SELVLLFLYV GVIALWHAFD
160 170 180 190 200
DRRLAGRAAG ILVLIGVVNL PIIHYSVEWW NTLHQGSTRM QQSIDPAMRS
210 220 230 240
PLRWSIFGFL LLSATLTLMR MRNLILLMEK RRPWVSELIL KRGRK
Sequence cautioni
The sequence AAA16391 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16391.1 Frameshift. U00096 Genomic DNA Translation: AAC75259.1 AP009048 Genomic DNA Translation: BAE76662.1 |
PIRi | E64989 |
RefSeqi | NP_416703.1, NC_000913.3 WP_001295447.1, NZ_STEB01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC75259; AAC75259; b2199 BAE76662; BAE76662; BAE76662 |
GeneIDi | 58347765 946703 |
KEGGi | ecj:JW2187 eco:b2199 |
PATRICi | fig|1411691.4.peg.37 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16391.1 Frameshift. U00096 Genomic DNA Translation: AAC75259.1 AP009048 Genomic DNA Translation: BAE76662.1 |
PIRi | E64989 |
RefSeqi | NP_416703.1, NC_000913.3 WP_001295447.1, NZ_STEB01000002.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263174, 20 interactors 851044, 1 interactor |
ComplexPortali | CPX-3568, CcmABCDE system I cytochrome c biogenesis complex |
IntActi | P0ABM1, 4 interactors |
MINTi | P0ABM1 |
STRINGi | 511145.b2199 |
Protein family/group databases
TCDBi | 9.B.14.2.3, the putative heme handling protein (hhp) family |
Proteomic databases
PaxDbi | P0ABM1 |
PRIDEi | P0ABM1 |
Genome annotation databases
EnsemblBacteriai | AAC75259; AAC75259; b2199 BAE76662; BAE76662; BAE76662 |
GeneIDi | 58347765 946703 |
KEGGi | ecj:JW2187 eco:b2199 |
PATRICi | fig|1411691.4.peg.37 |
Organism-specific databases
EchoBASEi | EB1987 |
Phylogenomic databases
eggNOGi | COG0755, Bacteria |
HOGENOMi | CLU_066538_2_0_6 |
InParanoidi | P0ABM1 |
PhylomeDBi | P0ABM1 |
Enzyme and pathway databases
BioCyci | EcoCyc:CCMC-MONOMER MetaCyc:CCMC-MONOMER |
Miscellaneous databases
PROi | PR:P0ABM1 |
Family and domain databases
InterProi | View protein in InterPro IPR002541, Cyt_c_assembly IPR003557, Cyt_c_biogenesis_CcmC |
Pfami | View protein in Pfam PF01578, Cytochrom_C_asm, 1 hit |
PRINTSi | PR01386, CCMCBIOGNSIS |
TIGRFAMsi | TIGR01191, ccmC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCMC_ECOLI | |
Accessioni | P0ABM1Primary (citable) accession number: P0ABM1 Secondary accession number(s): P33929, Q2MAP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | February 10, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families