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Entry version 115 (08 May 2019)
Sequence version 1 (08 Nov 2005)
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Protein

Cytochrome c-552

Gene

nrfA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process (PubMed:9593308, PubMed:11863430, PubMed:18311941, PubMed:20629638). Has very low activity toward hydroxylamine (PubMed:11863430). Has even lower activity toward sulfite (PubMed:20629638). Sulfite reductase activity is maximal at neutral pH (By similarity).By similarity1 Publication4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Subject to competitive inhibition by sulfite.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=28 µM for nitrite1 Publication
  2. KM=30 µM for nitrite1 Publication
  3. KM=22 µM for nitrite1 Publication
  4. KM=70 µM for sulfite1 Publication
  5. KM=30 mM for hydroxylamine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: nitrate reduction (assimilation)

    This protein is involved in the pathway nitrate reduction (assimilation), which is part of Nitrogen metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway nitrate reduction (assimilation) and in Nitrogen metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi94Iron (heme 3 axial ligand)Combined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei122Heme 1 (covalent)Combined sources1
    Binding sitei125Heme 1 (covalent)Combined sources1
    Metal bindingi126Iron (heme 1 axial ligand)Combined sources1
    Binding sitei160Heme 2 (covalent)Combined sources1
    Binding sitei163Heme 2 (covalent)Combined sources1
    Metal bindingi164Iron (heme 2 axial ligand)Combined sources1
    Binding sitei209Heme 3 (covalent)Combined sources1
    Binding sitei212Heme 3 (covalent)Combined sources1
    Metal bindingi213Iron (heme 3 axial ligand)Combined sources1
    Metal bindingi215CalciumCombined sources1
    Metal bindingi216Calcium; via carbonyl oxygenCombined sources1
    Binding sitei216SubstrateCurated1
    Metal bindingi261Calcium; via carbonyl oxygenCombined sources1
    Metal bindingi263CalciumCombined sources1
    Binding sitei264SubstrateCurated1
    Metal bindingi275Iron (heme 5 axial ligand)Combined sources1
    Binding sitei282Heme 4 (covalent)Combined sources1
    Binding sitei285Heme 4 (covalent)Combined sources1
    Metal bindingi286Iron (heme 4 axial ligand)Combined sources1
    Metal bindingi301Iron (heme 2 axial ligand)Combined sources1
    Binding sitei314Heme 5 (covalent)Combined sources1
    Binding sitei317Heme 5 (covalent)Combined sources1
    Metal bindingi318Iron (heme 5 axial ligand)Combined sources1
    Metal bindingi393Iron (heme 4 axial ligand)Combined sources1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processElectron transport, Transport
    LigandCalcium, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:CYTOCHROMEC552-MONOMER
    ECOL316407:JW4031-MONOMER
    MetaCyc:CYTOCHROMEC552-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.7.2.2 2026

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P0ABK9

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00653

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytochrome c-5521 Publication (EC:1.7.2.24 Publications)
    Alternative name(s):
    Ammonia-forming cytochrome c nitrite reductase
    Short name:
    Cytochrome c nitrite reductase1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:nrfA
    Ordered Locus Names:b4070, JW4031
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    Escherichia coli strain K12 genome database

    More...
    EcoGenei
    EG11781 nrfA

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Periplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi126K → H, I or L: Almost complete loss of nitrite reductase activity. 1 Publication1
    Mutagenesisi263Q → E: Increases affinity for nitrite without changing Vmax. 1 Publication1

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB03317 Heme C

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000657827 – 478Cytochrome c-552Add BLAST452

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P0ABK9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P0ABK9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P0ABK9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Full induction attained in the presence of nitrite. Subject to glucose and nitrate repression.1 Publication

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:11863430, PubMed:18311941). Component of a membrane-associated heterooligomeric complex (Probable).Curated2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4259405, 27 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-36021N

    Protein interaction database and analysis system

    More...
    IntActi
    P0ABK9, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b4070

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1478
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P0ABK9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P0ABK9

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the cytochrome c-552 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105EAU Bacteria
    COG3303 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000278511

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P0ABK9

    KEGG Orthology (KO)

    More...
    KOi
    K03385

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P0ABK9

    Family and domain databases

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01182 Cytochrom_C552, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003321 Cyt_c552
    IPR017570 Cyt_c_NO2Rdtase_formate-dep
    IPR011031 Multihaem_cyt
    IPR036280 Multihaem_cyt_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR30633 PTHR30633, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02335 Cytochrom_C552, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000243 Cyt_c552, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48695 SSF48695, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR03152 cyto_c552_HCOOH, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51008 MULTIHEME_CYTC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P0ABK9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTRIKINARR IFSLLIPFFF FTSVHAEQTA APAKPVTVEA KNETFAPQHP
    60 70 80 90 100
    DQYLSWKATS EQSERVDALA EDPRLVILWA GYPFSRDYNK PRGHAFAVTD
    110 120 130 140 150
    VRETLRTGAP KNAEDGPLPM ACWSCKSPDV ARLIQKDGED GYFHGKWARG
    160 170 180 190 200
    GPEIVNNLGC ADCHNTASPE FAKGKPELTL SRPYAARAME AIGKPFEKAG
    210 220 230 240 250
    RFDQQSMVCG QCHVEYYFDG KNKAVKFPWD DGMKVENMEQ YYDKIAFSDW
    260 270 280 290 300
    TNSLSKTPML KAQHPEYETW TAGIHGKNNV TCIDCHMPKV QNAEGKLYTD
    310 320 330 340 350
    HKIGNPFDNF AQTCANCHTQ DKAALQKVVA ERKQSINDLK IKVEDQLVHA
    360 370 380 390 400
    HFEAKAALDA GATEAEMKPI QDDIRHAQWR WDLAIASHGI HMHAPEEGLR
    410 420 430 440 450
    MLGTAMDKAA DARTKLARLL ATKGITHEIQ IPDISTKEKA QQAIGLNMEQ
    460 470
    IKAEKQDFIK TVIPQWEEQA RKNGLLSQ
    Length:478
    Mass (Da):53,703
    Last modified:November 8, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF965E986412A0456
    GO

    <p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 53590 Da from positions 27 - 478. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X72298 Genomic DNA Translation: CAA51048.1
    U00006 Genomic DNA Translation: AAC43164.1
    U00096 Genomic DNA Translation: AAC77040.1
    AP009048 Genomic DNA Translation: BAE78072.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S39590

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418494.1, NC_000913.3
    WP_000196875.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC77040; AAC77040; b4070
    BAE78072; BAE78072; BAE78072

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948571

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW4031
    eco:b4070

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.2634

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X72298 Genomic DNA Translation: CAA51048.1
    U00006 Genomic DNA Translation: AAC43164.1
    U00096 Genomic DNA Translation: AAC77040.1
    AP009048 Genomic DNA Translation: BAE78072.1
    PIRiS39590
    RefSeqiNP_418494.1, NC_000913.3
    WP_000196875.1, NZ_LN832404.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1GU6X-ray2.50A/C/E/G27-478[»]
    2RDZX-ray1.74A/B/C/D27-478[»]
    2RF7X-ray2.04A/B/C/D37-477[»]
    3L1TX-ray2.30A/B/C/D27-478[»]
    3TORX-ray2.00A/B/C/D27-478[»]
    4WJYX-ray2.15A/B27-478[»]
    SMRiP0ABK9
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi4259405, 27 interactors
    DIPiDIP-36021N
    IntActiP0ABK9, 3 interactors
    STRINGi511145.b4070

    Chemistry databases

    DrugBankiDB03317 Heme C

    Proteomic databases

    jPOSTiP0ABK9
    PaxDbiP0ABK9
    PRIDEiP0ABK9

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAC77040; AAC77040; b4070
    BAE78072; BAE78072; BAE78072
    GeneIDi948571
    KEGGiecj:JW4031
    eco:b4070
    PATRICifig|1411691.4.peg.2634

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB1729
    EcoGeneiEG11781 nrfA

    Phylogenomic databases

    eggNOGiENOG4105EAU Bacteria
    COG3303 LUCA
    HOGENOMiHOG000278511
    InParanoidiP0ABK9
    KOiK03385
    PhylomeDBiP0ABK9

    Enzyme and pathway databases

    UniPathwayiUPA00653
    BioCyciEcoCyc:CYTOCHROMEC552-MONOMER
    ECOL316407:JW4031-MONOMER
    MetaCyc:CYTOCHROMEC552-MONOMER
    BRENDAi1.7.2.2 2026
    SABIO-RKiP0ABK9

    Miscellaneous databases

    EvolutionaryTraceiP0ABK9

    Protein Ontology

    More...
    PROi
    PR:P0ABK9

    Family and domain databases

    HAMAPiMF_01182 Cytochrom_C552, 1 hit
    InterProiView protein in InterPro
    IPR003321 Cyt_c552
    IPR017570 Cyt_c_NO2Rdtase_formate-dep
    IPR011031 Multihaem_cyt
    IPR036280 Multihaem_cyt_sf
    PANTHERiPTHR30633 PTHR30633, 1 hit
    PfamiView protein in Pfam
    PF02335 Cytochrom_C552, 1 hit
    PIRSFiPIRSF000243 Cyt_c552, 1 hit
    SUPFAMiSSF48695 SSF48695, 1 hit
    TIGRFAMsiTIGR03152 cyto_c552_HCOOH, 1 hit
    PROSITEiView protein in PROSITE
    PS51008 MULTIHEME_CYTC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRFA_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABK9
    Secondary accession number(s): P32050, Q2M6N4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: May 8, 2019
    This is version 115 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
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