UniProtKB - P0ABJ6 (CYOD_ECOLI)
Protein
Cytochrome bo(3) ubiquinol oxidase subunit 4
Gene
cyoD
Organism
Escherichia coli (strain K12)
Status
Functioni
Cytochrome bo3 ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.3 Publications
GO - Molecular functioni
- cytochrome bo3 ubiquinol oxidase activity Source: EcoCyc
- cytochrome o ubiquinol oxidase activity Source: InterPro
- electron transfer activity Source: EcoCyc
- oxidoreduction-driven active transmembrane transporter activity Source: EcoCyc
- proton transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- aerobic electron transport chain Source: EcoCyc
- aerobic respiration Source: EcoCyc
- electron transport coupled proton transport Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:CYOD-MONOMER MetaCyc:CYOD-MONOMER |
Protein family/group databases
TCDBi | 3.D.4.5.1, the proton-translocating cytochrome oxidase (cox) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome bo(3) ubiquinol oxidase subunit 4Alternative name(s): Cytochrome o ubiquinol oxidase subunit 4 Short name: Cytochrome o subunit 4 Oxidase bo(3) subunit 4 Ubiquinol oxidase chain D Ubiquinol oxidase polypeptide IV Ubiquinol oxidase subunit 4 |
Gene namesi | Name:cyoD Ordered Locus Names:b0429, JW0419 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 18 – 36 | HelicalCuratedAdd BLAST | 19 | |
Topological domaini | 37 – 45 | PeriplasmicCurated | 9 | |
Transmembranei | 46 – 64 | HelicalCuratedAdd BLAST | 19 | |
Topological domaini | 65 – 80 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 81 – 99 | HelicalCuratedAdd BLAST | 19 | |
Topological domaini | 100 – 109 | PeriplasmicCurated | 10 |
GO - Cellular componenti
- cytochrome o ubiquinol oxidase complex Source: EcoCyc
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183910 | 1 – 109 | Cytochrome bo(3) ubiquinol oxidase subunit 4Add BLAST | 109 |
Proteomic databases
PaxDbi | P0ABJ6 |
PRIDEi | P0ABJ6 |
Interactioni
Subunit structurei
Heterooctamer of two A chains, two B chains, two C chains and two D chains.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 4260871, 223 interactors |
ComplexPortali | CPX-2102, Cytochrome o ubiquinol oxidase complex |
DIPi | DIP-48238N |
IntActi | P0ABJ6, 1 interactor |
STRINGi | 511145.b0429 |
Structurei
3D structure databases
SMRi | P0ABJ6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0ABJ6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome c oxidase bacterial subunit 4 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3125, Bacteria |
HOGENOMi | CLU_140945_1_0_6 |
InParanoidi | P0ABJ6 |
PhylomeDBi | P0ABJ6 |
Family and domain databases
InterProi | View protein in InterPro IPR005171, Cyt_c_oxidase_su4_prok IPR014210, Cyt_o_ubiqinol_oxidase_su4 |
Pfami | View protein in Pfam PF03626, COX4_pro, 1 hit |
TIGRFAMsi | TIGR02847, CyoD, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ABJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHSTDHSGA SHGSVKTYMT GFILSIILTV IPFWMVMTGA ASPAVILGTI
60 70 80 90 100
LAMAVVQVLV HLVCFLHMNT KSDEGWNMTA FVFTVLIIAI LVVGSIWIMW
NLNYNMMMH
Sequence cautioni
The sequence AAB40185 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05492 Genomic DNA Translation: AAA23634.1 U82664 Genomic DNA Translation: AAB40185.1 Different initiation. U00096 Genomic DNA Translation: AAC73532.1 AP009048 Genomic DNA Translation: BAE76209.1 |
PIRi | D42226 |
RefSeqi | NP_414963.1, NC_000913.3 WP_000019869.1, NZ_STEB01000007.1 |
Genome annotation databases
EnsemblBacteriai | AAC73532; AAC73532; b0429 BAE76209; BAE76209; BAE76209 |
GeneIDi | 58463754 944918 |
KEGGi | ecj:JW0419 eco:b0429 |
PATRICi | fig|1411691.4.peg.1848 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05492 Genomic DNA Translation: AAA23634.1 U82664 Genomic DNA Translation: AAB40185.1 Different initiation. U00096 Genomic DNA Translation: AAC73532.1 AP009048 Genomic DNA Translation: BAE76209.1 |
PIRi | D42226 |
RefSeqi | NP_414963.1, NC_000913.3 WP_000019869.1, NZ_STEB01000007.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FFT | X-ray | 3.50 | ||||
SMRi | P0ABJ6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260871, 223 interactors |
ComplexPortali | CPX-2102, Cytochrome o ubiquinol oxidase complex |
DIPi | DIP-48238N |
IntActi | P0ABJ6, 1 interactor |
STRINGi | 511145.b0429 |
Protein family/group databases
TCDBi | 3.D.4.5.1, the proton-translocating cytochrome oxidase (cox) superfamily |
Proteomic databases
PaxDbi | P0ABJ6 |
PRIDEi | P0ABJ6 |
Genome annotation databases
EnsemblBacteriai | AAC73532; AAC73532; b0429 BAE76209; BAE76209; BAE76209 |
GeneIDi | 58463754 944918 |
KEGGi | ecj:JW0419 eco:b0429 |
PATRICi | fig|1411691.4.peg.1848 |
Organism-specific databases
EchoBASEi | EB0178 |
Phylogenomic databases
eggNOGi | COG3125, Bacteria |
HOGENOMi | CLU_140945_1_0_6 |
InParanoidi | P0ABJ6 |
PhylomeDBi | P0ABJ6 |
Enzyme and pathway databases
BioCyci | EcoCyc:CYOD-MONOMER MetaCyc:CYOD-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0ABJ6 |
PROi | PR:P0ABJ6 |
Family and domain databases
InterProi | View protein in InterPro IPR005171, Cyt_c_oxidase_su4_prok IPR014210, Cyt_o_ubiqinol_oxidase_su4 |
Pfami | View protein in Pfam PF03626, COX4_pro, 1 hit |
TIGRFAMsi | TIGR02847, CyoD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYOD_ECOLI | |
Accessioni | P0ABJ6Primary (citable) accession number: P0ABJ6 Secondary accession number(s): P18403, P77116, Q2MBZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 25, 2005 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families