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Protein

Cytochrome bo(3) ubiquinol oxidase subunit 3

Gene

cyoC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome bo3 ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.3 Publications

GO - Molecular functioni

  • cytochrome bo3 ubiquinol oxidase activity Source: EcoCyc
  • cytochrome-c oxidase activity Source: InterPro
  • cytochrome o ubiquinol oxidase activity Source: InterPro
  • electron transfer activity Source: EcoCyc
  • oxidoreduction-driven active transmembrane transporter activity Source: EcoCyc
  • proton transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • aerobic electron transport chain Source: EcoCyc
  • aerobic respiration Source: EcoCyc
  • electron transport coupled proton transport Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYOC-MONOMER
MetaCyc:CYOC-MONOMER

Protein family/group databases

TCDBi3.D.4.5.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bo(3) ubiquinol oxidase subunit 3
Alternative name(s):
Cytochrome o ubiquinol oxidase subunit 3
Short name:
Cytochrome o subunit 3
Oxidase bo(3) subunit 3
Ubiquinol oxidase chain C
Ubiquinol oxidase polypeptide III
Ubiquinol oxidase subunit 3
Gene namesi
Name:cyoC
Ordered Locus Names:b0430, JW0420
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10180 cyoC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicCuratedAdd BLAST31
Transmembranei32 – 50HelicalCuratedAdd BLAST19
Topological domaini51 – 66PeriplasmicCuratedAdd BLAST16
Transmembranei67 – 85HelicalCuratedAdd BLAST19
Topological domaini86 – 101CytoplasmicCuratedAdd BLAST16
Transmembranei102 – 120HelicalCuratedAdd BLAST19
Topological domaini121 – 142PeriplasmicCuratedAdd BLAST22
Transmembranei143 – 161HelicalCuratedAdd BLAST19
Topological domaini162 – 184CytoplasmicCuratedAdd BLAST23
Transmembranei185 – 203HelicalCuratedAdd BLAST19
Topological domaini204PeriplasmicCurated1

GO - Cellular componenti

  • cytochrome o ubiquinol oxidase complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838931 – 204Cytochrome bo(3) ubiquinol oxidase subunit 3Add BLAST204

Proteomic databases

PaxDbiP0ABJ3
PRIDEiP0ABJ3

Interactioni

Subunit structurei

Heterooctamer of two A chains, two B chains, two C chains and two D chains.2 Publications

Protein-protein interaction databases

BioGridi4261578, 211 interactors
ComplexPortaliCPX-2102 cytochrome o ubiquinol oxidase complex
DIPiDIP-47944N
IntActiP0ABJ3, 1 interactor
STRINGi316385.ECDH10B_0386

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 30Combined sources7
Helixi33 – 36Combined sources4
Helixi39 – 47Combined sources9
Turni48 – 53Combined sources6
Helixi66 – 76Combined sources11
Helixi77 – 79Combined sources3
Turni80 – 84Combined sources5
Helixi86 – 88Combined sources3
Turni89 – 92Combined sources4
Helixi95 – 98Combined sources4
Helixi100 – 125Combined sources26
Turni135 – 137Combined sources3
Helixi138 – 146Combined sources9
Helixi149 – 152Combined sources4
Helixi155 – 166Combined sources12
Helixi176 – 194Combined sources19
Helixi195 – 202Combined sources8

3D structure databases

ProteinModelPortaliP0ABJ3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABJ3

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CCU Bacteria
COG1845 LUCA
HOGENOMiHOG000086398
InParanoidiP0ABJ3
KOiK02299
OMAiPWPLTGA
PhylomeDBiP0ABJ3

Family and domain databases

CDDicd02863 Ubiquinol_oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
IPR014206 Cyt_c_ubiqinol_oxidase_su3
IPR033946 Ubiquinol_oxase_su3_dom
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
TIGRFAMsiTIGR02842 CyoC, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL
60 70 80 90 100
VNGTAGGPTG KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS
110 120 130 140 150
WLALTWLFGA GFIGMEIYEF HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV
160 170 180 190 200
TSGLIWMAVL MVQIARRGLT STNRTRIMCL SLFWHFLDVV WICVFTVVYL

MGAM
Length:204
Mass (Da):22,623
Last modified:October 25, 2005 - v1
Checksum:iF1D6ABF9EB6CB5AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05492 Genomic DNA Translation: AAA23633.1
U82664 Genomic DNA Translation: AAB40186.1
U00096 Genomic DNA Translation: AAC73533.1
AP009048 Genomic DNA Translation: BAE76210.1
PIRiC42226
RefSeqiNP_414964.1, NC_000913.3
WP_000179819.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73533; AAC73533; b0430
BAE76210; BAE76210; BAE76210
GeneIDi946897
KEGGiecj:JW0420
eco:b0430
PATRICifig|1411691.4.peg.1847

Similar proteinsi

Entry informationi

Entry nameiCYOC_ECOLI
AccessioniPrimary (citable) accession number: P0ABJ3
Secondary accession number(s): P18402, Q2MBZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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