cyoC

Functionⁱ

Cytochrome bo₃ ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.3 Publications

GO - Molecular functionⁱ

cytochrome bo3 ubiquinol oxidase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 6308657
- 7045115
cytochrome-c oxidase activity Source: InterPro
cytochrome o ubiquinol oxidase activity Source: InterPro
electron transfer activity
Source: EcoCyc
Inferred from direct assayⁱ
oxidoreduction-driven active transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 1850294
- 2544445
proton transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 1850294
- 2544445

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aerobic electron transport chain
Source: EcoCyc
Inferred from direct assayⁱ
- 3013300
aerobic respiration
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 2981797
- 9378722
electron transport coupled proton transport
Source: EcoCyc
Inferred from direct assayⁱ
- 2544445

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Electron transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:CYOC-MONOMER MetaCyc:CYOC-MONOMER

BioCycⁱ

EcoCyc:CYOC-MONOMER
MetaCyc:CYOC-MONOMER

Protein family/group databases

TCDBⁱ	3.D.4.5.1 the proton-translocating cytochrome oxidase (cox) superfamily

TCDBⁱ

3.D.4.5.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome bo(3) ubiquinol oxidase subunit 3 Alternative name(s): Cytochrome o ubiquinol oxidase subunit 3 Short name: Cytochrome o subunit 3 Oxidase bo(3) subunit 3 Ubiquinol oxidase chain C Ubiquinol oxidase polypeptide III Ubiquinol oxidase subunit 3
Gene namesⁱ	Name:cyoC Ordered Locus Names:b0430, JW0420
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10180 cyoC

EcoGeneⁱ

EG10180 cyoC

Subcellular locationⁱ

Cell inner membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 31	CytoplasmicCuratedAdd BLAST	31
Transmembraneⁱ	32 – 50	HelicalCuratedAdd BLAST	19
Topological domainⁱ	51 – 66	PeriplasmicCuratedAdd BLAST	16
Transmembraneⁱ	67 – 85	HelicalCuratedAdd BLAST	19
Topological domainⁱ	86 – 101	CytoplasmicCuratedAdd BLAST	16
Transmembraneⁱ	102 – 120	HelicalCuratedAdd BLAST	19
Topological domainⁱ	121 – 142	PeriplasmicCuratedAdd BLAST	22
Transmembraneⁱ	143 – 161	HelicalCuratedAdd BLAST	19
Topological domainⁱ	162 – 184	CytoplasmicCuratedAdd BLAST	23
Transmembraneⁱ	185 – 203	HelicalCuratedAdd BLAST	19
Topological domainⁱ	204	PeriplasmicCurated	1

GO - Cellular componentⁱ

cytochrome o ubiquinol oxidase complex
Source: EcoCyc
Inferred from direct assayⁱ
- 11017202
- 9378722
integral component of plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 11017202
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996
- 17309111

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose).2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183893	1 – 204	Cytochrome bo(3) ubiquinol oxidase subunit 3Add BLAST		204

Proteomic databases

PaxDbⁱ	P0ABJ3
PRIDEⁱ	P0ABJ3

Interactionⁱ

Subunit structureⁱ

Heterooctamer of two A chains, two B chains, two C chains and two D chains.2 Publications

Protein-protein interaction databases

BioGridⁱ	4261578, 211 interactors
ComplexPortalⁱ	CPX-2102 Cytochrome o ubiquinol oxidase complex
Database of interacting proteins More...DIPⁱ	DIP-47944N
IntActⁱ	P0ABJ3, 1 interactor
STRINGⁱ	316385.ECDH10B_0386

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	24 – 30	Combined sources	7
Helixⁱ	33 – 36	Combined sources	4
Helixⁱ	39 – 47	Combined sources	9
Turnⁱ	48 – 53	Combined sources	6
Helixⁱ	66 – 76	Combined sources	11
Helixⁱ	77 – 79	Combined sources	3
Turnⁱ	80 – 84	Combined sources	5
Helixⁱ	86 – 88	Combined sources	3
Turnⁱ	89 – 92	Combined sources	4
Helixⁱ	95 – 98	Combined sources	4
Helixⁱ	100 – 125	Combined sources	26
Turnⁱ	135 – 137	Combined sources	3
Helixⁱ	138 – 146	Combined sources	9
Helixⁱ	149 – 152	Combined sources	4
Helixⁱ	155 – 166	Combined sources	12
Helixⁱ	176 – 194	Combined sources	19
Helixⁱ	195 – 202	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P0ABJ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P0ABJ3

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome c oxidase subunit 3 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105CCU Bacteria COG1845 LUCA
HOGENOMⁱ	HOG000086398
InParanoidⁱ	P0ABJ3
KEGG Orthology (KO) More...KOⁱ	K02299
OMAⁱ	PWPLTGA
PhylomeDBⁱ	P0ABJ3

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02863 Ubiquinol_oxidase_III, 1 hit
Gene3Dⁱ	1.20.120.80, 1 hit
InterProⁱ	View protein in InterPro IPR024791 Cyt_c/ubiquinol_Oxase_su3 IPR000298 Cyt_c_oxidase-like_su3 IPR035973 Cyt_c_oxidase_su3-like_sf IPR013833 Cyt_c_oxidase_su3_a-hlx IPR014206 Cyt_c_ubiqinol_oxidase_su3 IPR033946 Ubiquinol_oxase_su3_dom
PANTHERⁱ	PTHR11403 PTHR11403, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00510 COX3, 1 hit
SUPFAMⁱ	SSF81452 SSF81452, 1 hit
TIGRFAMsⁱ	TIGR02842 CyoC, 1 hit
PROSITEⁱ	View protein in PROSITE PS50253 COX3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0ABJ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL 
        60         70         80         90        100
VNGTAGGPTG KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS 
       110        120        130        140        150
WLALTWLFGA GFIGMEIYEF HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV 
       160        170        180        190        200
TSGLIWMAVL MVQIARRGLT STNRTRIMCL SLFWHFLDVV WICVFTVVYL 

MGAM

Length:204

Mass (Da):22,623

Last modified:October 25, 2005 - v1

Checksum:ⁱF1D6ABF9EB6CB5AD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05492 Genomic DNA Translation: AAA23633.1 U82664 Genomic DNA Translation: AAB40186.1 U00096 Genomic DNA Translation: AAC73533.1 AP009048 Genomic DNA Translation: BAE76210.1
PIRⁱ	C42226
NCBI Reference Sequences More...RefSeqⁱ	NP_414964.1, NC_000913.3 WP_000179819.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73533; AAC73533; b0430 BAE76210; BAE76210; BAE76210
GeneIDⁱ	946897
KEGGⁱ	ecj:JW0420 eco:b0430
PATRICⁱ	fig\|1411691.4.peg.1847

Protein	Similar proteins		Species	Score	Length	Source
P0ABJ3	Cytochrome bo(3) ubiquinol oxidase subunit 3		ECOL6		204	UniRef100_P0ABJ4
Cytochrome bo(3) ubiquinol oxidase subunit 3		SHIFL		204
Cytochrome o ubiquinol oxidase, subunit III		Escherichia coli 2-210-07_S3_C3		205
Cytochrome o ubiquinol oxidase subunit III		Escherichia coli NCCP15648		204
Cytochrome bo(3) ubiquinol oxidase subunit 3		Escherichia coli O145 str. RM9872		204
+139

Protein	Similar proteins		Species	Score	Length	Source
P0ABJ3	Cytochrome bo(3) ubiquinol oxidase subunit 3		ECOL6		204	UniRef90_P0ABJ4
Cytochrome bo(3) ubiquinol oxidase subunit 3		SHIFL		204
Cytochrome o ubiquinol oxidase, subunit III		Escherichia coli 2-210-07_S3_C3		205
Cytochrome o ubiquinol oxidase subunit III		Escherichia coli NCCP15648		204
Cytochrome bo(3) ubiquinol oxidase subunit 3		Escherichia coli O145 str. RM9872		204
+558

Protein	Similar proteins		Species	Score	Length	Source
P0ABJ3	Cytochrome bo(3) ubiquinol oxidase subunit 3		ECOL6		204	UniRef50_P0ABJ4
Cytochrome bo(3) ubiquinol oxidase subunit 3		SHIFL		204
Cytochrome bo(3) ubiquinol oxidase subunit 3		PSEPU		207
Cytochrome bo(3) ubiquinol oxidase subunit 3		PSEAE		209
Cytochrome o ubiquinol oxidase, subunit III		Escherichia coli 2-210-07_S3_C3		205
+6032

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05492 Genomic DNA Translation: AAA23633.1 U82664 Genomic DNA Translation: AAB40186.1 U00096 Genomic DNA Translation: AAC73533.1 AP009048 Genomic DNA Translation: BAE76210.1
PIRⁱ	C42226
RefSeqⁱ	NP_414964.1, NC_000913.3 WP_000179819.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1FFT	X-ray	3.50	C/H	25-204	[»]
ProteinModelPortalⁱ	P0ABJ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261578, 211 interactors
ComplexPortalⁱ	CPX-2102 Cytochrome o ubiquinol oxidase complex
DIPⁱ	DIP-47944N
IntActⁱ	P0ABJ3, 1 interactor
STRINGⁱ	316385.ECDH10B_0386

Protein family/group databases

TCDBⁱ	3.D.4.5.1 the proton-translocating cytochrome oxidase (cox) superfamily

TCDBⁱ

3.D.4.5.1 the proton-translocating cytochrome oxidase (cox) superfamily

Proteomic databases

PaxDbⁱ	P0ABJ3
PRIDEⁱ	P0ABJ3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC73533; AAC73533; b0430 BAE76210; BAE76210; BAE76210
GeneIDⁱ	946897
KEGGⁱ	ecj:JW0420 eco:b0430
PATRICⁱ	fig\|1411691.4.peg.1847

Organism-specific databases

EchoBASEⁱ	EB0177
EcoGeneⁱ	EG10180 cyoC

Phylogenomic databases

eggNOGⁱ	ENOG4105CCU Bacteria COG1845 LUCA
HOGENOMⁱ	HOG000086398
InParanoidⁱ	P0ABJ3
KOⁱ	K02299
OMAⁱ	PWPLTGA
PhylomeDBⁱ	P0ABJ3

Enzyme and pathway databases

BioCycⁱ	EcoCyc:CYOC-MONOMER MetaCyc:CYOC-MONOMER

BioCycⁱ

EcoCyc:CYOC-MONOMER
MetaCyc:CYOC-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P0ABJ3
Protein Ontology More...PROⁱ	PR:P0ABJ3

Family and domain databases

CDDⁱ	cd02863 Ubiquinol_oxidase_III, 1 hit
Gene3Dⁱ	1.20.120.80, 1 hit
InterProⁱ	View protein in InterPro IPR024791 Cyt_c/ubiquinol_Oxase_su3 IPR000298 Cyt_c_oxidase-like_su3 IPR035973 Cyt_c_oxidase_su3-like_sf IPR013833 Cyt_c_oxidase_su3_a-hlx IPR014206 Cyt_c_ubiqinol_oxidase_su3 IPR033946 Ubiquinol_oxase_su3_dom
PANTHERⁱ	PTHR11403 PTHR11403, 1 hit
Pfamⁱ	View protein in Pfam PF00510 COX3, 1 hit
SUPFAMⁱ	SSF81452 SSF81452, 1 hit
TIGRFAMsⁱ	TIGR02842 CyoC, 1 hit
PROSITEⁱ	View protein in PROSITE PS50253 COX3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CYOC_ECOLI
Accessionⁱ	P0ABJ3Primary (citable) accession number: P0ABJ3 Secondary accession number(s): P18402, Q2MBZ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
	Last sequence update:	October 25, 2005
	Last modified:	September 12, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0ABJ3 (CYOC_ECOLI)

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Cytochrome bo(3) ubiquinol oxidase subunit 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ