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Protein

Rod shape-determining protein MreD

Gene

mreD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.

GO - Biological processi

  • regulation of cell shape Source: EcoCyc

Keywordsi

Biological processCell shape

Enzyme and pathway databases

BioCyciEcoCyc:EG10610-MONOMER

Protein family/group databases

TCDBi9.B.157.1.3 the cell shape-determining mrebcd (mrebcd) family

Names & Taxonomyi

Protein namesi
Recommended name:
Rod shape-determining protein MreD
Gene namesi
Name:mreD
Ordered Locus Names:b3249, JW3218
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10610 mreD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 55PeriplasmicSequence analysis4
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 105CytoplasmicSequence analysisAdd BLAST29
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 131PeriplasmicSequence analysis5
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 162CytoplasmicSequence analysis10

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000627701 – 162Rod shape-determining protein MreDAdd BLAST162

Proteomic databases

PaxDbiP0ABH4
PRIDEiP0ABH4

Interactioni

Protein-protein interaction databases

BioGridi4262449, 394 interactors
DIPiDIP-10257N
STRINGi316385.ECDH10B_3425

Structurei

3D structure databases

ProteinModelPortaliP0ABH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MreD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105VQ7 Bacteria
COG2891 LUCA
HOGENOMiHOG000266108
InParanoidiP0ABH4
KOiK03571
OMAiHRRLLWF

Family and domain databases

InterProiView protein in InterPro
IPR007227 Cell_shape_determining_MreD
IPR026034 MreD_proteobac
PANTHERiPTHR37484 PTHR37484, 1 hit
PfamiView protein in Pfam
PF04093 MreD, 1 hit
PIRSFiPIRSF018472 MreD_proteobac, 1 hit
TIGRFAMsiTIGR03426 shape_MreD, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASYRSQGRW VIWLSFLIAL LLQIMPWPDN LIVFRPNWVL LILLYWILAL
60 70 80 90 100
PHRVNVGTGF VMGAILDLIS GSTLGVRVLA MSIIAYLVAL KYQLFRNLAL
110 120 130 140 150
WQQALVVMLL SLVVDIIVFW AEFLVINVSF RPEVFWSSVV NGVLWPWIFL
160
LMRKVRQQFA VQ
Length:162
Mass (Da):18,788
Last modified:October 25, 2005 - v1
Checksum:i4D9DEAE3F38F99C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31792 Genomic DNA Translation: AAA24156.1
U18997 Genomic DNA Translation: AAA58052.1
U00096 Genomic DNA Translation: AAC76281.1
AP009048 Genomic DNA Translation: BAE77291.1
X57166 Genomic DNA Translation: CAA40455.1
PIRiJV0060
RefSeqiNP_417715.1, NC_000913.3
WP_000179409.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76281; AAC76281; b3249
BAE77291; BAE77291; BAE77291
GeneIDi947756
KEGGiecj:JW3218
eco:b3249
PATRICifig|1411691.4.peg.3480

Entry informationi

Entry nameiMRED_ECOLI
AccessioniPrimary (citable) accession number: P0ABH4
Secondary accession number(s): P16927, Q2M8W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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