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Protein

Cell division protein FtsA

Gene

ftsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential cell division protein that assists in the assembly of the Z ring (PubMed:11847116). May serve as the principal membrane anchor for the Z ring (PubMed:15752196). Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN (PubMed:9282742, PubMed:9495771, PubMed:9603865, PubMed:9882666, PubMed:10027987, PubMed:24750258). Binds ATP (PubMed:11053380).9 Publications

GO - Molecular functioni

  • ATP binding Source: EcoCyc
  • identical protein binding Source: EcoCyc

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:EG10339-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsAUniRule annotation
Gene namesi
Name:ftsAUniRule annotation
Synonyms:divA
Ordered Locus Names:b0094, JW0092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10339 ftsA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi210D → A: Does not bind ATP. 1 Publication1
Mutagenesisi408W → E: Prevents localization to the Z ring. Lack of activity. 1 Publication1
Mutagenesisi409I → E: Prevents localization to the Z ring. Lack of activity. 1 Publication1
Mutagenesisi411R → E: Does not affect localization or function. 1 Publication1
Mutagenesisi412L → E: Prevents localization to the Z ring. Lack of activity. 1 Publication1
Mutagenesisi415W → E: Prevents localization to the Z ring. Lack of activity. 1 Publication1
Mutagenesisi416L → E: Prevents localization to the Z ring. Lack of activity. 1 Publication1
Mutagenesisi420F → E: Does not affect localization or function. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3309010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000627341 – 420Cell division protein FtsAAdd BLAST420

Proteomic databases

EPDiP0ABH0
PaxDbiP0ABH0
PRIDEiP0ABH0

Interactioni

Subunit structurei

Self-interacts (PubMed:11053380, PubMed:17501933). Interacts with FtsZ. This interaction plays an essential role in cell division (PubMed:8917533, PubMed:17501933). Interacts directly with the cytoplasmic region of FtsN (PubMed:22328664, PubMed:24750258).5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4261886, 382 interactors
DIPiDIP-47983N
IntActiP0ABH0, 27 interactors
MINTiP0ABH0
STRINGi316385.ECDH10B_0076

Structurei

3D structure databases

ProteinModelPortaliP0ABH0
SMRiP0ABH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The extreme C-terminus is essential for localization to the membrane and the Z ring, self-interaction and activity.2 Publications

Sequence similaritiesi

Belongs to the FtsA/MreB family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105CIT Bacteria
COG0849 LUCA
HOGENOMiHOG000049205
InParanoidiP0ABH0
KOiK03590
PhylomeDBiP0ABH0

Family and domain databases

HAMAPiMF_02033 FtsA, 1 hit
InterProiView protein in InterPro
IPR020823 Cell_div_FtsA
IPR003494 SHS2_FtsA
PfamiView protein in Pfam
PF02491 SHS2_FTSA, 1 hit
PIRSFiPIRSF003101 FtsA, 1 hit
SMARTiView protein in SMART
SM00842 FtsA, 1 hit
TIGRFAMsiTIGR01174 ftsA, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG
60 70 80 90 100
VNDLESVVKC VQRAIDQAEL MADCQISSVY LALSGKHISC QNEIGMVPIS
110 120 130 140 150
EEEVTQEDVE NVVHTAKSVR VRDEHRVLHV IPQEYAIDYQ EGIKNPVGLS
160 170 180 190 200
GVRMQAKVHL ITCHNDMAKN IVKAVERCGL KVDQLIFAGL ASSYSVLTED
210 220 230 240 250
ERELGVCVVD IGGGTMDIAV YTGGALRHTK VIPYAGNVVT SDIAYAFGTP
260 270 280 290 300
PSDAEAIKVR HGCALGSIVG KDESVEVPSV GGRPPRSLQR QTLAEVIEPR
310 320 330 340 350
YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR
360 370 380 390 400
VFHTQVRIGA PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR
410 420
VTASVGSWIK RLNSWLRKEF
Length:420
Mass (Da):45,330
Last modified:January 1, 1988 - v1
Checksum:iC2475377A229B982
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339A → R (PubMed:6094474).Curated1
Sequence conflicti339A → R (PubMed:2846985).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02668 Genomic DNA Translation: AAA23817.1
M36531 Genomic DNA Translation: AAA23811.1
X55034 Genomic DNA Translation: CAA38871.1
U00096 Genomic DNA Translation: AAC73205.1
AP009048 Genomic DNA Translation: BAB96662.1
PIRiB23318 CEECA
RefSeqiNP_414636.1, NC_000913.3
WP_000588474.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73205; AAC73205; b0094
BAB96662; BAB96662; BAB96662
GeneIDi944778
KEGGiecj:JW0092
eco:b0094
PATRICifig|1411691.4.peg.2186

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02668 Genomic DNA Translation: AAA23817.1
M36531 Genomic DNA Translation: AAA23811.1
X55034 Genomic DNA Translation: CAA38871.1
U00096 Genomic DNA Translation: AAC73205.1
AP009048 Genomic DNA Translation: BAB96662.1
PIRiB23318 CEECA
RefSeqiNP_414636.1, NC_000913.3
WP_000588474.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0ABH0
SMRiP0ABH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261886, 382 interactors
DIPiDIP-47983N
IntActiP0ABH0, 27 interactors
MINTiP0ABH0
STRINGi316385.ECDH10B_0076

Chemistry databases

ChEMBLiCHEMBL3309010

Proteomic databases

EPDiP0ABH0
PaxDbiP0ABH0
PRIDEiP0ABH0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73205; AAC73205; b0094
BAB96662; BAB96662; BAB96662
GeneIDi944778
KEGGiecj:JW0092
eco:b0094
PATRICifig|1411691.4.peg.2186

Organism-specific databases

EchoBASEiEB0335
EcoGeneiEG10339 ftsA

Phylogenomic databases

eggNOGiENOG4105CIT Bacteria
COG0849 LUCA
HOGENOMiHOG000049205
InParanoidiP0ABH0
KOiK03590
PhylomeDBiP0ABH0

Enzyme and pathway databases

BioCyciEcoCyc:EG10339-MONOMER

Miscellaneous databases

PROiPR:P0ABH0

Family and domain databases

HAMAPiMF_02033 FtsA, 1 hit
InterProiView protein in InterPro
IPR020823 Cell_div_FtsA
IPR003494 SHS2_FtsA
PfamiView protein in Pfam
PF02491 SHS2_FTSA, 1 hit
PIRSFiPIRSF003101 FtsA, 1 hit
SMARTiView protein in SMART
SM00842 FtsA, 1 hit
TIGRFAMsiTIGR01174 ftsA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFTSA_ECOLI
AccessioniPrimary (citable) accession number: P0ABH0
Secondary accession number(s): P06137, Q47229
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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