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Entry version 114 (02 Jun 2021)
Sequence version 1 (25 Oct 2005)
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Protein

Peptidoglycan glycosyltransferase MrdB

Gene

mrdB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peptidoglycan polymerase that is essential for cell wall elongation (PubMed:27643381).

Also required for the maintenance of the rod cell shape (PubMed:2644207).

Functions probably in conjunction with the penicillin-binding protein 2 (mrdA) (PubMed:2644207, PubMed:27643381).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10607-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00219

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.103.1.2, the bacterial murein precursor exporter (mpe) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidoglycan glycosyltransferase MrdBUniRule annotationCurated (EC:2.4.1.129UniRule annotation1 Publication)
Short name:
PGTUniRule annotationCurated
Alternative name(s):
Cell elongation protein RodAUniRule annotationCurated
Cell wall polymeraseUniRule annotationCurated
Peptidoglycan polymerase1 PublicationUniRule annotation
Short name:
PG polymerase1 PublicationUniRule annotation
Rod shape-determining proteinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrdB1 PublicationUniRule annotation
Synonyms:rodA1 Publication
Ordered Locus Names:b0634, JW0629
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19PeriplasmicSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 49CytoplasmicSequence analysis9
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 74PeriplasmicSequence analysis4
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 135CytoplasmicSequence analysisAdd BLAST40
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 159PeriplasmicSequence analysis3
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 182CytoplasmicSequence analysis2
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 262PeriplasmicSequence analysisAdd BLAST59
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 311CytoplasmicSequence analysisAdd BLAST28
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 335PeriplasmicSequence analysis3
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 370CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

At 42 degrees Celsius, mutation causes formation of spherical cells and mecillinam resistance.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000627151 – 370Peptidoglycan glycosyltransferase MrdBAdd BLAST370

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0ABG7

PRoteomics IDEntifications database

More...
PRIDEi
P0ABG7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259910, 288 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5718, Elongasome complex

Database of interacting proteins

More...
DIPi
DIP-48062N

Protein interaction database and analysis system

More...
IntActi
P0ABG7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0634

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEDS family. MrdB/RodA subfamily.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0772, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029243_2_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0ABG7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0ABG7

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_02079, PGT_RodA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018365, Cell_cycle_FtsW-rel_CS
IPR001182, FtsW/RodA
IPR011923, RodA/MrdB

The PANTHER Classification System

More...
PANTHERi
PTHR30474, PTHR30474, 1 hit
PTHR30474:SF1, PTHR30474:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01098, FTSW_RODA_SPOVE, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02210, rodA_shape, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00428, FTSW_RODA_SPOVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0ABG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDNPNKKTF WDKVHLDPTM LLILLALLVY SALVIWSASG QDIGMMERKI
60 70 80 90 100
GQIAMGLVIM VVMAQIPPRV YEGWAPYLYI ICIILLVAVD AFGAISKGAQ
110 120 130 140 150
RWLDLGIVRF QPSEIAKIAV PLMVARFINR DVCPPSLKNT GIALVLIFMP
160 170 180 190 200
TLLVAAQPDL GTSILVALSG LFVLFLSGLS WRLIGVAVVL VAAFIPILWF
210 220 230 240 250
FLMHDYQRQR VMMLLDPESD PLGAGYHIIQ SKIAIGSGGL RGKGWLHGTQ
260 270 280 290 300
SQLEFLPERH TDFIFAVLAE ELGLVGILIL LALYILLIMR GLWIAARAQT
310 320 330 340 350
TFGRVMAGGL MLILFVYVFV NIGMVSGILP VVGVPLPLVS YGGSALIVLM
360 370
AGFGIVMSIH THRKMLSKSV
Length:370
Mass (Da):40,476
Last modified:October 25, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68FCDF8D6B123D69
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M22857 Genomic DNA Translation: AAA24571.1
U82598 Genomic DNA Translation: AAB40834.1
U00096 Genomic DNA Translation: AAC73735.1
AP009048 Genomic DNA Translation: BAA35277.1
M18276 Genomic DNA Translation: AAA24551.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JT0500, BVECRD

NCBI Reference Sequences

More...
RefSeqi
NP_415167.1, NC_000913.3
WP_000131719.1, NZ_STEB01000031.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73735; AAC73735; b0634
BAA35277; BAA35277; BAA35277

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
61756017
945238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0629
eco:b0634

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1634

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22857 Genomic DNA Translation: AAA24571.1
U82598 Genomic DNA Translation: AAB40834.1
U00096 Genomic DNA Translation: AAC73735.1
AP009048 Genomic DNA Translation: BAA35277.1
M18276 Genomic DNA Translation: AAA24551.1
PIRiJT0500, BVECRD
RefSeqiNP_415167.1, NC_000913.3
WP_000131719.1, NZ_STEB01000031.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4259910, 288 interactors
ComplexPortaliCPX-5718, Elongasome complex
DIPiDIP-48062N
IntActiP0ABG7, 2 interactors
STRINGi511145.b0634

Protein family/group databases

TCDBi2.A.103.1.2, the bacterial murein precursor exporter (mpe) family

Proteomic databases

PaxDbiP0ABG7
PRIDEiP0ABG7

Genome annotation databases

EnsemblBacteriaiAAC73735; AAC73735; b0634
BAA35277; BAA35277; BAA35277
GeneIDi61756017
945238
KEGGiecj:JW0629
eco:b0634
PATRICifig|1411691.4.peg.1634

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0602

Phylogenomic databases

eggNOGiCOG0772, Bacteria
HOGENOMiCLU_029243_2_2_6
InParanoidiP0ABG7
PhylomeDBiP0ABG7

Enzyme and pathway databases

UniPathwayiUPA00219
BioCyciEcoCyc:EG10607-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0ABG7

Family and domain databases

HAMAPiMF_02079, PGT_RodA, 1 hit
InterProiView protein in InterPro
IPR018365, Cell_cycle_FtsW-rel_CS
IPR001182, FtsW/RodA
IPR011923, RodA/MrdB
PANTHERiPTHR30474, PTHR30474, 1 hit
PTHR30474:SF1, PTHR30474:SF1, 1 hit
PfamiView protein in Pfam
PF01098, FTSW_RODA_SPOVE, 1 hit
TIGRFAMsiTIGR02210, rodA_shape, 1 hit
PROSITEiView protein in PROSITE
PS00428, FTSW_RODA_SPOVE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRODA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABG7
Secondary accession number(s): P13409, P15035
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: June 2, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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