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UniProtKB - P0ABG4 (FTSW_ECOLI)

Entry version 128 (02 Dec 2020)
Sequence version 1 (25 Oct 2005)
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Protein

Probable peptidoglycan glycosyltransferase FtsW

Gene

ftsW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peptidoglycan polymerase that is essential for cell division (Probable). Functions probably in conjunction with the penicillin-binding protein 3 (ftsI) (PubMed:9603865, PubMed:11807049). Required for localization of FtsI (PubMed:11807049).2 Publications2 Publications

Caution

Has previously been proposed to be a lipid II flippase that transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane (PubMed:21386816, PubMed:24711460), but recent evidence suggests that FtsW may function as a peptidoglycan polymerase (PubMed:27643381). The identity of the lipid II flippase is still controversial with conflicting in vivo and in vitro results, but MurJ (AC P0AF16) is probably the lipid II flippase.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG10344-MONOMER
MetaCyc:EG10344-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00219

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.103.1.1, the bacterial murein precursor exporter (mpe) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable peptidoglycan glycosyltransferase FtsWUniRule annotationBy similarity (EC:2.4.1.129UniRule annotationBy similarity)
Short name:
PGTUniRule annotationBy similarity
Alternative name(s):
Cell division protein FtsWUniRule annotationCurated
Cell wall polymeraseUniRule annotationBy similarity
Lipid II flippase FtsWCurated
Peptidoglycan polymeraseUniRule annotationBy similarity
Short name:
PG polymeraseUniRule annotationBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ftsWUniRule annotation
Ordered Locus Names:b0089, JW0087
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Topological domaini34 – 47PeriplasmicSequence analysisAdd BLAST14
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Topological domaini69 – 86CytoplasmicSequence analysisAdd BLAST18
Transmembranei87 – 107HelicalUniRule annotationAdd BLAST21
Topological domaini108 – 111PeriplasmicSequence analysis4
Transmembranei112 – 132HelicalUniRule annotationAdd BLAST21
Topological domaini133 – 174CytoplasmicSequence analysisAdd BLAST42
Transmembranei175 – 194HelicalUniRule annotationAdd BLAST20
Topological domaini195 – 197PeriplasmicSequence analysis3
Transmembranei198 – 217HelicalUniRule annotationAdd BLAST20
Topological domaini218 – 221CytoplasmicSequence analysis4
Transmembranei222 – 244HelicalUniRule annotationAdd BLAST23
Topological domaini245 – 301PeriplasmicSequence analysisAdd BLAST57
Transmembranei302 – 322HelicalUniRule annotationAdd BLAST21
Topological domaini323 – 342CytoplasmicSequence analysisAdd BLAST20
Transmembranei343 – 363HelicalUniRule annotationAdd BLAST21
Topological domaini364 – 373PeriplasmicSequence analysis10
Transmembranei374 – 394HelicalUniRule annotationAdd BLAST21
Topological domaini395 – 414CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi145R → A: Loss of flippase activity. Does not affect localization at the division site. 1 Publication1
Mutagenesisi150 – 152ELT → AAA: Does not affect flippase activity. 1 Publication3
Mutagenesisi153K → N: Loss of flippase activity. Does not affect localization at the division site. 1 Publication1
Mutagenesisi154 – 156LSL → AAA: Does not affect flippase activity. 1 Publication3
Mutagenesisi170E → K in ftsW201; TS; blocks division at the initiation stage. 1
Mutagenesisi172R → S: Does not affect localization, but affects its thermosensitivity. 1 Publication1
Mutagenesisi181P → L in ftsW1640; TS; blocks division at a late stage. 1
Mutagenesisi243R → Q: Lack of activity. 1 Publication1
Mutagenesisi253P → L in ftsW263; TS; blocks division at the initiation stage. 1
Mutagenesisi311G → D: Thermosensitive. Fails to localize to the division site at 42 degrees Celsius. 1 Publication1
Mutagenesisi368P → A: Cannot recruit FtsI at the division site; when associated with A-375. 1 Publication1
Mutagenesisi375P → A: Cannot recruit FtsI at the division site; when associated with A-368. 1 Publication1
Mutagenesisi402R → Q: Does not affect localization and activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000627001 – 414Probable peptidoglycan glycosyltransferase FtsWAdd BLAST414

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0ABG4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0ABG4

PRoteomics IDEntifications database

More...PRIDEi		P0ABG4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with FtsI.

Interacts also with FtsL, FtsQ and FtsN.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261096, 505 interactors

Database of interacting proteins

More...DIPi		DIP-47989N

Protein interaction database and analysis system

More...IntActi		P0ABG4, 14 interactors

Molecular INTeraction database

More...MINTi		P0ABG4

STRING: functional protein association networks

More...STRINGi		511145.b0089

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The periplasmic loop between transmembrane domains 7 and 8 is essential for activity and the loop between transmembrane domains 9 and 10 is involved in the recruitment of FtsI at the division site.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEDS family. FtsW subfamily.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0772, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029243_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0ABG4

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0ABG4

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_00913, PGT_FtsW_proteobact, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018365, Cell_cycle_FtsW-rel_CS
IPR013437, FtsW
IPR001182, FtsW/RodA

The PANTHER Classification System

More...PANTHERi		PTHR30474, PTHR30474, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01098, FTSW_RODA_SPOVE, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02614, ftsW, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00428, FTSW_RODA_SPOVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0ABG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSLPRLKM PRLPGFSILV WISTALKGWV MGSREKDTDS LIMYDRTLLW 
        60         70         80         90        100
LTFGLAAIGF IMVTSASMPI GQRLTNDPFF FAKRDGVYLI LAFILAIITL 
       110        120        130        140        150
RLPMEFWQRY SATMLLGSII LLMIVLVVGS SVKGASRWID LGLLRIQPAE 
       160        170        180        190        200
LTKLSLFCYI ANYLVRKGDE VRNNLRGFLK PMGVILVLAV LLLAQPDLGT 
       210        220        230        240        250
VVVLFVTTLA MLFLAGAKLW QFIAIIGMGI SAVVLLILAE PYRIRRVTAF 
       260        270        280        290        300
WNPWEDPFGS GYQLTQSLMA FGRGELWGQG LGNSVQKLEY LPEAHTDFIF 
       310        320        330        340        350
AIIGEELGYV GVVLALLMVF FVAFRAMSIG RKALEIDHRF SGFLACSIGI 
       360        370        380        390        400
WFSFQALVNV GAAAGMLPTK GLTLPLISYG GSSLLIMSTA IMMLLRIDYE 
       410 
TRLEKAQAFV RGSR
Length:414
Mass (Da):45,987
Last modified:October 25, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7935EC952AD9A1F3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M30807 Genomic DNA Translation: AAA83859.1
X55034 Genomic DNA Translation: CAA38866.1
U00096 Genomic DNA Translation: AAC73200.1
AP009048 Genomic DNA Translation: BAB96657.1
X52644 Genomic DNA Translation: CAA36866.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32581, CEECFW

NCBI Reference Sequences

More...RefSeqi		NP_414631.1, NC_000913.3
WP_001295532.1, NZ_STEB01000010.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73200; AAC73200; b0089
BAB96657; BAB96657; BAB96657

Database of genes from NCBI RefSeq genomes

More...GeneIDi		49586098
946322

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0087
eco:b0089

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2191

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30807 Genomic DNA Translation: AAA83859.1
X55034 Genomic DNA Translation: CAA38866.1
U00096 Genomic DNA Translation: AAC73200.1
AP009048 Genomic DNA Translation: BAB96657.1
X52644 Genomic DNA Translation: CAA36866.1
PIRiA32581, CEECFW
RefSeqiNP_414631.1, NC_000913.3
WP_001295532.1, NZ_STEB01000010.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261096, 505 interactors
DIPiDIP-47989N
IntActiP0ABG4, 14 interactors
MINTiP0ABG4
STRINGi511145.b0089

Protein family/group databases

TCDBi2.A.103.1.1, the bacterial murein precursor exporter (mpe) family

Proteomic databases

jPOSTiP0ABG4
PaxDbiP0ABG4
PRIDEiP0ABG4

Genome annotation databases

EnsemblBacteriaiAAC73200; AAC73200; b0089
BAB96657; BAB96657; BAB96657
GeneIDi49586098
946322
KEGGiecj:JW0087
eco:b0089
PATRICifig|1411691.4.peg.2191

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0340

Phylogenomic databases

eggNOGiCOG0772, Bacteria
HOGENOMiCLU_029243_1_1_6
InParanoidiP0ABG4
PhylomeDBiP0ABG4

Enzyme and pathway databases

UniPathwayiUPA00219
BioCyciEcoCyc:EG10344-MONOMER
MetaCyc:EG10344-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0ABG4

Family and domain databases

HAMAPiMF_00913, PGT_FtsW_proteobact, 1 hit
InterProiView protein in InterPro
IPR018365, Cell_cycle_FtsW-rel_CS
IPR013437, FtsW
IPR001182, FtsW/RodA
PANTHERiPTHR30474, PTHR30474, 1 hit
PfamiView protein in Pfam
PF01098, FTSW_RODA_SPOVE, 1 hit
TIGRFAMsiTIGR02614, ftsW, 1 hit
PROSITEiView protein in PROSITE
PS00428, FTSW_RODA_SPOVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFTSW_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABG4
Secondary accession number(s): P16457
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: December 2, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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