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UniProtKB - P0ABG3 (CDSA_SHIFL)
Protein
Phosphatidate cytidylyltransferase
Gene
cdsA
Organism
Shigella flexneri
Status
Functioni
Catalytic activityi
- EC:2.7.7.41
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate. This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase (EC:2.7.7.41)Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | Name:cdsA Ordered Locus Names:SF0165, S0168 |
Organismi | Shigella flexneri |
Taxonomic identifieri | 623 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 151 – 171 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 190 – 210 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 213 – 233 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090746 | 1 – 285 | Phosphatidate cytidylyltransferaseAdd BLAST | 285 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_037294_1_2_6 |
OrthoDBi | 1533756at2 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
i Sequence
Sequence statusi: Complete.
P0ABG3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT
60 70 80 90 100
TRSQRVWLAV LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL
110 120 130 140 150
LLVLFYPGSA AIWRNSKTLR LIFGVLTIVP FFWGMLALRA WHYDENHYSG
160 170 180 190 200
AIWLLYVMIL VWGADSGAYM FGKLFGKHKL APKVSPGKTW QGFIGGLATA
210 220 230 240 250
AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM FKREAGIKDS
260 270 280
GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL
Sequence cautioni
The sequence AAN41827 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAP15708 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN41827.2 Different initiation. AE014073 Genomic DNA Translation: AAP15708.1 Different initiation. |
RefSeqi | NP_706120.4, NC_004337.2 WP_000922446.1, NZ_WPGW01000006.1 |
Genome annotation databases
EnsemblBacteriai | AAN41827; AAN41827; SF0165 AAP15708; AAP15708; S0168 |
GeneIDi | 1024478 66671537 |
KEGGi | sfl:SF0165 sfx:S0168 |
PATRICi | fig|198214.7.peg.187 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN41827.2 Different initiation. AE014073 Genomic DNA Translation: AAP15708.1 Different initiation. |
RefSeqi | NP_706120.4, NC_004337.2 WP_000922446.1, NZ_WPGW01000006.1 |
3D structure databases
SMRi | P0ABG3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 198214.SF0165 |
Genome annotation databases
EnsemblBacteriai | AAN41827; AAN41827; SF0165 AAP15708; AAP15708; S0168 |
GeneIDi | 1024478 66671537 |
KEGGi | sfl:SF0165 sfx:S0168 |
PATRICi | fig|198214.7.peg.187 |
Phylogenomic databases
HOGENOMi | CLU_037294_1_2_6 |
OrthoDBi | 1533756at2 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDSA_SHIFL | |
Accessioni | P0ABG3Primary (citable) accession number: P0ABG3 Secondary accession number(s): P06466 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families