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Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Gene

accB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.1 Publication

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

  • acetyl-CoA carboxylase activity Source: EcoliWiki

GO - Biological processi

Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandBiotin

Enzyme and pathway databases

BioCyciEcoCyc:BCCP-MONOMER
MetaCyc:BCCP-MONOMER
BRENDAi6.4.1.2 2026
SABIO-RKiP0ABD8
UniPathwayi
UPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase1 Publication
Short name:
BCCP1 Publication
Gene namesi
Name:accB
Synonyms:fabE
Ordered Locus Names:b3255, JW3223
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10275 accB

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: InterPro
  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001468051 – 156Biotin carboxyl carrier protein of acetyl-CoA carboxylaseAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122N6-biotinyllysinePROSITE-ProRule annotation1 Publication1

Proteomic databases

EPDiP0ABD8
PaxDbiP0ABD8
PRIDEiP0ABD8

2D gel databases

SWISS-2DPAGEiP0ABD8

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
accCP2418210EBI-542320,EBI-542308

Protein-protein interaction databases

BioGridi4259533, 408 interactors
ComplexPortaliCPX-3206 Acetyl-CoA carboxylase complex
DIPiDIP-48007N
IntActiP0ABD8, 12 interactors
STRINGi316385.ECDH10B_3430

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00970
ProteinModelPortaliP0ABD8
SMRiP0ABD8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABD8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 156Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST84

Phylogenomic databases

eggNOGiENOG4105KM4 Bacteria
COG0511 LUCA
HOGENOMiHOG000008875
InParanoidiP0ABD8
KOiK02160
OMAiIKSPIIG
PhylomeDBiP0ABD8

Family and domain databases

InterProiView protein in InterPro
IPR001249 AcCoA_biotinCC
IPR001882 Biotin_BS
IPR000089 Biotin_lipoyl
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00364 Biotin_lipoyl, 1 hit
PRINTSiPR01071 ACOABIOTINCC
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00531 BCCP, 1 hit
PROSITEiView protein in PROSITE
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIRKIKKLI ELVEESGISE LEISEGEESV RISRAAPAAS FPVMQQAYAA
60 70 80 90 100
PMMQQPAQSN AAAPATVPSM EAPAAAEISG HIVRSPMVGT FYRTPSPDAK
110 120 130 140 150
AFIEVGQKVN VGDTLCIVEA MKMMNQIEAD KSGTVKAILV ESGQPVEFDE

PLVVIE
Length:156
Mass (Da):16,687
Last modified:October 25, 2005 - v1
Checksum:i05FFDCB912A683A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113D → N (PubMed:2575489).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14825 Genomic DNA Translation: CAA32933.1
M80458 Genomic DNA Translation: AAA23408.1
M32214 Genomic DNA Translation: AAA23744.1
M83198 Genomic DNA Translation: AAA23745.1
U18997 Genomic DNA Translation: AAA58058.1
U00096 Genomic DNA Translation: AAC76287.1
AP009048 Genomic DNA Translation: BAE77296.1
S52932 mRNA Translation: AAB24892.1
M79446 Genomic DNA No translation available.
PIRiA93687 BKEC9
RefSeqiNP_417721.1, NC_000913.3
WP_000354622.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76287; AAC76287; b3255
BAE77296; BAE77296; BAE77296
GeneIDi947758
KEGGiecj:JW3223
eco:b3255
PATRICifig|1411691.4.peg.3473

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14825 Genomic DNA Translation: CAA32933.1
M80458 Genomic DNA Translation: AAA23408.1
M32214 Genomic DNA Translation: AAA23744.1
M83198 Genomic DNA Translation: AAA23745.1
U18997 Genomic DNA Translation: AAA58058.1
U00096 Genomic DNA Translation: AAC76287.1
AP009048 Genomic DNA Translation: BAE77296.1
S52932 mRNA Translation: AAB24892.1
M79446 Genomic DNA No translation available.
PIRiA93687 BKEC9
RefSeqiNP_417721.1, NC_000913.3
WP_000354622.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6XNMR-A70-156[»]
1BDOX-ray1.80A77-156[»]
1K67model-B77-155[»]
1K69model-B77-156[»]
2BDONMR-A77-156[»]
3BDONMR-A75-156[»]
4HR7X-ray2.50B/D/G/I1-156[»]
DisProtiDP00970
ProteinModelPortaliP0ABD8
SMRiP0ABD8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259533, 408 interactors
ComplexPortaliCPX-3206 Acetyl-CoA carboxylase complex
DIPiDIP-48007N
IntActiP0ABD8, 12 interactors
STRINGi316385.ECDH10B_3430

2D gel databases

SWISS-2DPAGEiP0ABD8

Proteomic databases

EPDiP0ABD8
PaxDbiP0ABD8
PRIDEiP0ABD8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76287; AAC76287; b3255
BAE77296; BAE77296; BAE77296
GeneIDi947758
KEGGiecj:JW3223
eco:b3255
PATRICifig|1411691.4.peg.3473

Organism-specific databases

EchoBASEiEB0271
EcoGeneiEG10275 accB

Phylogenomic databases

eggNOGiENOG4105KM4 Bacteria
COG0511 LUCA
HOGENOMiHOG000008875
InParanoidiP0ABD8
KOiK02160
OMAiIKSPIIG
PhylomeDBiP0ABD8

Enzyme and pathway databases

UniPathwayi
UPA00094

BioCyciEcoCyc:BCCP-MONOMER
MetaCyc:BCCP-MONOMER
BRENDAi6.4.1.2 2026
SABIO-RKiP0ABD8

Miscellaneous databases

EvolutionaryTraceiP0ABD8
PROiPR:P0ABD8

Family and domain databases

InterProiView protein in InterPro
IPR001249 AcCoA_biotinCC
IPR001882 Biotin_BS
IPR000089 Biotin_lipoyl
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00364 Biotin_lipoyl, 1 hit
PRINTSiPR01071 ACOABIOTINCC
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00531 BCCP, 1 hit
PROSITEiView protein in PROSITE
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBCCP_ECOLI
AccessioniPrimary (citable) accession number: P0ABD8
Secondary accession number(s): P02905, Q2M8W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2005
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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