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Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Gene

accB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acetyl-CoA carboxylase activity Source: EcoliWiki

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandBiotin

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:BCCP-MONOMER
MetaCyc:BCCP-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.4.1.2 2026

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P0ABD8

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00094

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase1 Publication
Short name:
BCCP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:accB
Synonyms:fabE
Ordered Locus Names:b3255, JW3223
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10275 accB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: InterPro
  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001468051 – 156Biotin carboxyl carrier protein of acetyl-CoA carboxylaseAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei122N6-biotinyllysinePROSITE-ProRule annotation1 Publication1

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0ABD8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0ABD8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0ABD8

PRoteomics IDEntifications database

More...
PRIDEi
P0ABD8

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P0ABD8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
accCP2418210EBI-542320,EBI-542308

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259533, 408 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3206 Acetyl-CoA carboxylase complex

Database of interacting proteins

More...
DIPi
DIP-48007N

Protein interaction database and analysis system

More...
IntActi
P0ABD8, 12 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_3430

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6XNMR-A70-156[»]
1BDOX-ray1.80A77-156[»]
1K67model-B77-155[»]
1K69model-B77-156[»]
2BDONMR-A77-156[»]
3BDONMR-A75-156[»]
4HR7X-ray2.50B/D/G/I1-156[»]

Database of protein disorder

More...
DisProti
DP00970

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0ABD8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0ABD8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0ABD8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 156Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST84

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105KM4 Bacteria
COG0511 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008875

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0ABD8

KEGG Orthology (KO)

More...
KOi
K02160

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0ABD8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001249 AcCoA_biotinCC
IPR001882 Biotin_BS
IPR000089 Biotin_lipoyl
IPR011053 Single_hybrid_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00364 Biotin_lipoyl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01071 ACOABIOTINCC

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51230 SSF51230, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00531 BCCP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0ABD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIRKIKKLI ELVEESGISE LEISEGEESV RISRAAPAAS FPVMQQAYAA
60 70 80 90 100
PMMQQPAQSN AAAPATVPSM EAPAAAEISG HIVRSPMVGT FYRTPSPDAK
110 120 130 140 150
AFIEVGQKVN VGDTLCIVEA MKMMNQIEAD KSGTVKAILV ESGQPVEFDE

PLVVIE
Length:156
Mass (Da):16,687
Last modified:October 25, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05FFDCB912A683A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113D → N (PubMed:2575489).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14825 Genomic DNA Translation: CAA32933.1
M80458 Genomic DNA Translation: AAA23408.1
M32214 Genomic DNA Translation: AAA23744.1
M83198 Genomic DNA Translation: AAA23745.1
U18997 Genomic DNA Translation: AAA58058.1
U00096 Genomic DNA Translation: AAC76287.1
AP009048 Genomic DNA Translation: BAE77296.1
S52932 mRNA Translation: AAB24892.1
M79446 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
A93687 BKEC9

NCBI Reference Sequences

More...
RefSeqi
NP_417721.1, NC_000913.3
WP_000354622.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76287; AAC76287; b3255
BAE77296; BAE77296; BAE77296

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947758

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3223
eco:b3255

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3473

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14825 Genomic DNA Translation: CAA32933.1
M80458 Genomic DNA Translation: AAA23408.1
M32214 Genomic DNA Translation: AAA23744.1
M83198 Genomic DNA Translation: AAA23745.1
U18997 Genomic DNA Translation: AAA58058.1
U00096 Genomic DNA Translation: AAC76287.1
AP009048 Genomic DNA Translation: BAE77296.1
S52932 mRNA Translation: AAB24892.1
M79446 Genomic DNA No translation available.
PIRiA93687 BKEC9
RefSeqiNP_417721.1, NC_000913.3
WP_000354622.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6XNMR-A70-156[»]
1BDOX-ray1.80A77-156[»]
1K67model-B77-155[»]
1K69model-B77-156[»]
2BDONMR-A77-156[»]
3BDONMR-A75-156[»]
4HR7X-ray2.50B/D/G/I1-156[»]
DisProtiDP00970
ProteinModelPortaliP0ABD8
SMRiP0ABD8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259533, 408 interactors
ComplexPortaliCPX-3206 Acetyl-CoA carboxylase complex
DIPiDIP-48007N
IntActiP0ABD8, 12 interactors
STRINGi316385.ECDH10B_3430

2D gel databases

SWISS-2DPAGEiP0ABD8

Proteomic databases

EPDiP0ABD8
jPOSTiP0ABD8
PaxDbiP0ABD8
PRIDEiP0ABD8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76287; AAC76287; b3255
BAE77296; BAE77296; BAE77296
GeneIDi947758
KEGGiecj:JW3223
eco:b3255
PATRICifig|1411691.4.peg.3473

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0271
EcoGeneiEG10275 accB

Phylogenomic databases

eggNOGiENOG4105KM4 Bacteria
COG0511 LUCA
HOGENOMiHOG000008875
InParanoidiP0ABD8
KOiK02160
PhylomeDBiP0ABD8

Enzyme and pathway databases

UniPathwayi
UPA00094

BioCyciEcoCyc:BCCP-MONOMER
MetaCyc:BCCP-MONOMER
BRENDAi6.4.1.2 2026
SABIO-RKiP0ABD8

Miscellaneous databases

EvolutionaryTraceiP0ABD8

Protein Ontology

More...
PROi
PR:P0ABD8

Family and domain databases

InterProiView protein in InterPro
IPR001249 AcCoA_biotinCC
IPR001882 Biotin_BS
IPR000089 Biotin_lipoyl
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00364 Biotin_lipoyl, 1 hit
PRINTSiPR01071 ACOABIOTINCC
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00531 BCCP, 1 hit
PROSITEiView protein in PROSITE
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCCP_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABD8
Secondary accession number(s): P02905, Q2M8W0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2005
Last modified: January 16, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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