UniProtKB - P0ABD5 (ACCA_ECOLI)

BLAST

>sp|P0ABD5|ACCA_ECOLI Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha OS=Escherichia coli (strain K12) OX=83333 GN=accA PE=1 SV=2
MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGA
WQIAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQK
GRETKEKIRRNFGMPAPEGYRKALRLMQMAERFKMPIITFIDTPGAYPGVGAEERGQSEA
IARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKS
ADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVL
STEDLKNRRYQRLMSYGYA

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History
Entry version 121 (10 Oct 2018)
Sequence version 2 (23 Jan 2007)
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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO₂ group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotation1 Publication

Catalytic activityⁱ

[Biotin carboxyl-carrier protein]-N₆-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N₆-biotinyl-L-lysine + malonyl-CoA.UniRule annotation1 Publication

Activity regulationⁱ

Competitively inhibited by pyrrolidine dione antibiotic moiramide B (CPD1).1 Publication

Kineticsⁱ

Pathwayⁱ: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Biotin carboxylase (accC)

This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functionⁱ

acetyl-CoA carboxylase activity Source: InterPro
ATP binding Source: UniProtKB-KW
carboxyl- or carbamoyltransferase activity Source: UniProtKB-UniRule
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 23582331
- 24561554

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid biosynthetic process
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 10893421
long-chain fatty acid biosynthetic process
Source: EcoliWiki
Non-traceable author statementⁱ
- 18156466
malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER MetaCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER
SABIO-RKⁱ	P0ABD5
UniPathwayⁱ	UPA00655;UER00711

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotation (EC:2.1.3.15UniRule annotation1 Publication) Short name: ACCase subunit alphaUniRule annotation Short name: Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesⁱ	Name:accAUniRule annotation Ordered Locus Names:b0185, JW0180
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11647 accA

EcoGeneⁱ

EG11647 accA

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000146774	2 – 319	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaAdd BLAST		318

Proteomic databases

EPDⁱ	P0ABD5
PaxDbⁱ	P0ABD5
PRIDEⁱ	P0ABD5

Interactionⁱ

Subunit structureⁱ

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-542031,EBI-542031
accD	P0A9Q5	17	EBI-542031,EBI-542064

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 23582331
- 24561554

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	4259753, 211 interactors
ComplexPortalⁱ	CPX-3206 Acetyl-CoA carboxylase complex
Database of interacting proteins More...DIPⁱ	DIP-35897N
IntActⁱ	P0ABD5, 32 interactors
Molecular INTeraction database More...MINTⁱ	P0ABD5
STRINGⁱ	316385.ECDH10B_0165

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	10 – 14	Combined sources	5
Turnⁱ	15 – 20	Combined sources	6
Helixⁱ	39 – 43	Combined sources	5
Helixⁱ	44 – 48	Combined sources	5
Turnⁱ	49 – 52	Combined sources	4
Helixⁱ	53 – 56	Combined sources	4
Helixⁱ	60 – 67	Combined sources	8
Helixⁱ	75 – 82	Combined sources	8
Beta strandⁱ	84 – 88	Combined sources	5
Beta strandⁱ	93 – 95	Combined sources	3
Beta strandⁱ	101 – 108	Combined sources	8
Beta strandⁱ	111 – 118	Combined sources	8
Helixⁱ	126 – 129	Combined sources	4
Helixⁱ	131 – 133	Combined sources	3
Helixⁱ	137 – 152	Combined sources	16
Beta strandⁱ	157 – 164	Combined sources	8
Helixⁱ	170 – 174	Combined sources	5
Helixⁱ	177 – 189	Combined sources	13
Beta strandⁱ	195 – 204	Combined sources	10
Helixⁱ	205 – 209	Combined sources	5
Beta strandⁱ	215 – 219	Combined sources	5
Beta strandⁱ	224 – 228	Combined sources	5
Helixⁱ	230 – 237	Combined sources	8
Helixⁱ	244 – 251	Combined sources	8
Helixⁱ	255 – 259	Combined sources	5
Turnⁱ	260 – 262	Combined sources	3
Helixⁱ	275 – 277	Combined sources	3
Helixⁱ	279 – 293	Combined sources	15
Turnⁱ	294 – 299	Combined sources	6
Helixⁱ	302 – 315	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P0ABD5
SMRⁱ	P0ABD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P0ABD5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 296	CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST		262

Sequence similaritiesⁱ

Belongs to the AccA family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4107QM9 Bacteria COG0825 LUCA
HOGENOMⁱ	HOG000273832
InParanoidⁱ	P0ABD5
KEGG Orthology (KO) More...KOⁱ	K01962
OMAⁱ	CSSILWR
PhylomeDBⁱ	P0ABD5

Family and domain databases

HAMAPⁱ	MF_00823 AcetylCoA_CT_alpha, 1 hit
InterProⁱ	View protein in InterPro IPR001095 Acetyl_CoA_COase_a_su IPR029045 ClpP/crotonase-like_dom_sf IPR011763 COA_CT_C
PANTHERⁱ	PTHR42853 PTHR42853, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03255 ACCA, 1 hit
PRINTSⁱ	PR01069 ACCCTRFRASEA
SUPFAMⁱ	SSF52096 SSF52096, 1 hit
TIGRFAMsⁱ	TIGR00513 accA, 1 hit
PROSITEⁱ	View protein in PROSITE PS50989 COA_CT_CTER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P0ABD5-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSLNFLDFEQ PIAELEAKID SLTAVSRQDE KLDINIDEEV HRLREKSVEL 
        60         70         80         90        100
TRKIFADLGA WQIAQLARHP QRPYTLDYVR LAFDEFDELA GDRAYADDKA 
       110        120        130        140        150
IVGGIARLDG RPVMIIGHQK GRETKEKIRR NFGMPAPEGY RKALRLMQMA 
       160        170        180        190        200
ERFKMPIITF IDTPGAYPGV GAEERGQSEA IARNLREMSR LGVPVVCTVI 
       210        220        230        240        250
GEGGSGGALA IGVGDKVNML QYSTYSVISP EGCASILWKS ADKAPLAAEA 
       260        270        280        290        300
MGIIAPRLKE LKLIDSIIPE PLGGAHRNPE AMAASLKAQL LADLADLDVL 
       310 
STEDLKNRRY QRLMSYGYA

Length:319

Mass (Da):35,242

Last modified:January 23, 2007 - v2

Checksum:ⁱA810DE891CEA2B4F

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M96394 Genomic DNA Translation: AAA70370.1 D49445 Genomic DNA Translation: BAA08425.1 U70214 Genomic DNA Translation: AAB08614.1 U00096 Genomic DNA Translation: AAC73296.1 AP009048 Genomic DNA Translation: BAA77860.2 D87518 Genomic DNA Translation: BAA21655.1 M19334 Genomic DNA No translation available.
PIRⁱ	A43452
NCBI Reference Sequences More...RefSeqⁱ	NP_414727.1, NC_000913.3 WP_000055741.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73296; AAC73296; b0185 BAA77860; BAA77860; BAA77860
GeneIDⁱ	944895
KEGGⁱ	ecj:JW0180 eco:b0185
PATRICⁱ	fig\|1411691.4.peg.2094

Protein	Similar proteins		Species	Score	Length	Source
P0ABD5	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		ECO24		319	UniRef100_A7ZHS5
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		ECO55		319
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		ECO57		319
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		ECO5E		319
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		ECO81		319
+128

Protein	Similar proteins		Species	Score	Length	Source
P0ABD5	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		ENT38		319	UniRef90_A4W6T0
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		KLEP3		319
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		KLEP7		319
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		SHISS		319
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		ECO45		319
+914

Protein	Similar proteins		Species	Score	Length	Source
P0ABD5	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		CHLTE		334	UniRef50_Q8KG09
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		CHLP8		336
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		CHLPM		335
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		HAEIN		315
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha		HAEI8		315
+2041

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M96394 Genomic DNA Translation: AAA70370.1 D49445 Genomic DNA Translation: BAA08425.1 U70214 Genomic DNA Translation: AAB08614.1 U00096 Genomic DNA Translation: AAC73296.1 AP009048 Genomic DNA Translation: BAA77860.2 D87518 Genomic DNA Translation: BAA21655.1 M19334 Genomic DNA No translation available.
PIRⁱ	A43452
RefSeqⁱ	NP_414727.1, NC_000913.3 WP_000055741.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2F9Y	X-ray	3.20	A	1-319	[»]
ProteinModelPortalⁱ	P0ABD5
SMRⁱ	P0ABD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4259753, 211 interactors
ComplexPortalⁱ	CPX-3206 Acetyl-CoA carboxylase complex
DIPⁱ	DIP-35897N
IntActⁱ	P0ABD5, 32 interactors
MINTⁱ	P0ABD5
STRINGⁱ	316385.ECDH10B_0165

Proteomic databases

EPDⁱ	P0ABD5
PaxDbⁱ	P0ABD5
PRIDEⁱ	P0ABD5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC73296; AAC73296; b0185 BAA77860; BAA77860; BAA77860
GeneIDⁱ	944895
KEGGⁱ	ecj:JW0180 eco:b0185
PATRICⁱ	fig\|1411691.4.peg.2094

Organism-specific databases

EchoBASEⁱ	EB1600
EcoGeneⁱ	EG11647 accA

Phylogenomic databases

eggNOGⁱ	ENOG4107QM9 Bacteria COG0825 LUCA
HOGENOMⁱ	HOG000273832
InParanoidⁱ	P0ABD5
KOⁱ	K01962
OMAⁱ	CSSILWR
PhylomeDBⁱ	P0ABD5

Enzyme and pathway databases

UniPathwayⁱ	UPA00655;UER00711
BioCycⁱ	EcoCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER MetaCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER
SABIO-RKⁱ	P0ABD5

Miscellaneous databases

EvolutionaryTraceⁱ	P0ABD5
Protein Ontology More...PROⁱ	PR:P0ABD5

Family and domain databases

HAMAPⁱ	MF_00823 AcetylCoA_CT_alpha, 1 hit
InterProⁱ	View protein in InterPro IPR001095 Acetyl_CoA_COase_a_su IPR029045 ClpP/crotonase-like_dom_sf IPR011763 COA_CT_C
PANTHERⁱ	PTHR42853 PTHR42853, 1 hit
Pfamⁱ	View protein in Pfam PF03255 ACCA, 1 hit
PRINTSⁱ	PR01069 ACCCTRFRASEA
SUPFAMⁱ	SSF52096 SSF52096, 1 hit
TIGRFAMsⁱ	TIGR00513 accA, 1 hit
PROSITEⁱ	View protein in PROSITE PS50989 COA_CT_CTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACCA_ECOLI
Accessionⁱ	P0ABD5Primary (citable) accession number: P0ABD5 Secondary accession number(s): P30867
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0ABD5 (ACCA_ECOLI)

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Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

accA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: malonyl-CoA biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: malonyl-CoA biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ