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Protein

Arsenate reductase

Gene

arsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity).By similarity

Catalytic activityi

Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.

GO - Molecular functioni

  • arsenate reductase (glutaredoxin) activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • response to arsenic-containing substance Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Enzyme and pathway databases

BioCyciEcoCyc:EG12237-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductase (EC:1.20.4.1)
Alternative name(s):
Arsenical pump modifier
Gene namesi
Name:arsC
Synonyms:arsG
Ordered Locus Names:b3503, JW3470
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12237 arsC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625361 – 141Arsenate reductaseAdd BLAST141

Proteomic databases

PaxDbiP0AB96
PRIDEiP0AB96

Interactioni

Protein-protein interaction databases

BioGridi4261140, 7 interactors
IntActiP0AB96, 2 interactors
STRINGi316385.ECDH10B_3679

Structurei

3D structure databases

ProteinModelPortaliP0AB96
SMRiP0AB96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsC family.Curated

Phylogenomic databases

eggNOGiENOG4105K89 Bacteria
COG1393 LUCA
HOGENOMiHOG000059717
InParanoidiP0AB96
KOiK00537
OMAiHYLENPP
PhylomeDBiP0AB96

Family and domain databases

CDDicd03034 ArsC_ArsC, 1 hit
InterProiView protein in InterPro
IPR006659 Arsenate_reductase
IPR006660 Arsenate_reductase-like
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF03960 ArsC, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00014 arsC, 1 hit
PROSITEiView protein in PROSITE
PS51353 ARSC, 1 hit

Sequencei

Sequence statusi: Complete.

P0AB96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITIYHNP ACGTSRNTLE MIRNSGTEPT IIHYLETPPT RDELVKLIAD
60 70 80 90 100
MGISVRALLR KNVEPYEELG LAEDKFTDDR LIDFMLQHPI LINRPIVVTP
110 120 130 140
LGTRLCRPSE VVLEILPDAQ KGAFSKEDGE KVVDEAGKRL K
Length:141
Mass (Da):15,853
Last modified:November 8, 2005 - v1
Checksum:i5490FBBD14B24D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA Translation: CAA56363.1
U00039 Genomic DNA Translation: AAB18479.1
U00096 Genomic DNA Translation: AAC76528.1
AP009048 Genomic DNA Translation: BAE77791.1
PIRiC56269
RefSeqiNP_417960.1, NC_000913.3
WP_000065769.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76528; AAC76528; b3503
BAE77791; BAE77791; BAE77791
GeneIDi948018
KEGGiecj:JW3470
eco:b3503
PATRICifig|1411691.4.peg.3217

Similar proteinsi

Entry informationi

Entry nameiARSC_ECOLI
AccessioniPrimary (citable) accession number: P0AB96
Secondary accession number(s): P37311, Q2M7G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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