arsB

Functionⁱ

Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity).By similarity

GO - Molecular functionⁱ

antimonite secondary active transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 14970228
arsenite secondary active transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 14970228

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimonite transport
Source: EcoCyc
Inferred from direct assayⁱ
- 14970228
arsenite transport
Source: EcoCyc
Inferred from direct assayⁱ
- 14970228
response to arsenic-containing substance Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Arsenical resistance, Transport

Biological process

Arsenical resistance, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:ARSF-MONOMER MetaCyc:ARSF-MONOMER

BioCycⁱ

EcoCyc:ARSF-MONOMER
MetaCyc:ARSF-MONOMER

Protein family/group databases

TCDBⁱ	3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

TCDBⁱ

3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arsenical pump membrane protein Alternative name(s): Arsenic efflux pump protein
Gene namesⁱ	Name:arsB Synonyms:arsF Ordered Locus Names:b3502, JW3469
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12236 arsB

EcoGeneⁱ

EG12236 arsB

Subcellular locationⁱ

Cell inner membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 20	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	21 – 41	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	42 – 45	PeriplasmicSequence analysis	4
Transmembraneⁱ	46 – 66	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	67 – 97	CytoplasmicSequence analysisAdd BLAST	31
Transmembraneⁱ	98 – 118	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	119 – 120	PeriplasmicSequence analysis	2
Transmembraneⁱ	121 – 141	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	142 – 151	CytoplasmicSequence analysis	10
Transmembraneⁱ	152 – 172	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	173 – 177	PeriplasmicSequence analysis	5
Transmembraneⁱ	178 – 198	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	199 – 227	CytoplasmicSequence analysisAdd BLAST	29
Transmembraneⁱ	228 – 248	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	249 – 269	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	270 – 273	CytoplasmicSequence analysis	4
Transmembraneⁱ	274 – 294	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	295 – 310	PeriplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	311 – 331	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	332 – 406	CytoplasmicSequence analysisAdd BLAST	75
Transmembraneⁱ	407 – 427	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	428 – 429	PeriplasmicSequence analysis	2

GO - Cellular componentⁱ

integral component of plasma membrane
Source: EcoliWiki
Inferred from direct assayⁱ
- 20196076
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000201467	1 – 429	Arsenical pump membrane proteinAdd BLAST		429

Proteomic databases

PaxDbⁱ	P0AB93
PRIDEⁱ	P0AB93

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4261325, 7 interactors
IntActⁱ	P0AB93, 1 interactor
STRINGⁱ	316385.ECDH10B_3678

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0AB93
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ArsB family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4107R5R Bacteria COG1055 LUCA
HOGENOMⁱ	HOG000005271
InParanoidⁱ	P0AB93
KEGG Orthology (KO) More...KOⁱ	K03893
PhylomeDBⁱ	P0AB93

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01118 ArsB_permease, 1 hit
InterProⁱ	View protein in InterPro IPR000802 Arsenical_pump_ArsB
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02040 ArsB, 1 hit
PRINTSⁱ	PR00758 ARSENICPUMP
TIGRFAMsⁱ	TIGR00935 2a45, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0AB93-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLAGAIFVL TIVLVIWQPK GLGIGWSATL GAVLALVTGV VHPGDIPVVW 
        60         70         80         90        100
NIVWNATAAF IAVIIISLLL DESGFFEWAA LHVSRWGNGR GRLLFTWIVL 
       110        120        130        140        150
LGAAVAALFA NDGAALILTP IVIAMLLALG FSKGTTLAFV MAAGFIADTA 
       160        170        180        190        200
SLPLIVSNLV NIVSADFFGL GFREYASVMV PVDIAAIVAT LVMLHLYFRK 
       210        220        230        240        250
DIPQNYDMAL LKSPAEAIKD PATFKTGWVV LLLLLVGFFV LEPLGIPVSA 
       260        270        280        290        300
IAAVGALILF VVAKRGHAIN TGKVLRGAPW QIVIFSLGMY LVVYGLRNAG 
       310        320        330        340        350
LTEYLSGVLN VLADNGLWAA TLGTGFLTAF LSSIMNNMPT VLVGALSIDG 
       360        370        380        390        400
STASGVIKEA MVYANVIGCD LGPKITPIGS LATLLWLHVL SQKNMTISWG 
       410        420 
YYFRTGIIMT LPVLFVTLAA LALRLSFTL

Length:429

Mass (Da):45,497

Last modified:November 8, 2005 - v1

Checksum:ⁱ66EB1C03E479B6E9

GO

Sequence cautionⁱ

The sequence AAB18478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80057 Genomic DNA Translation: CAA56362.1 U00039 Genomic DNA Translation: AAB18478.1 Different initiation. U00096 Genomic DNA Translation: AAC76527.2 AP009048 Genomic DNA Translation: BAE77792.1
PIRⁱ	S47723
NCBI Reference Sequences More...RefSeqⁱ	NP_417959.4, NC_000913.3 WP_000922639.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC76527; AAC76527; b3502 BAE77792; BAE77792; BAE77792
GeneIDⁱ	948011
KEGGⁱ	ecj:JW3469 eco:b3502
PATRICⁱ	fig\|511145.12.peg.3606

Protein	Similar proteins		Species	Score	Length	Source
P0AB93	Arsenical pump membrane protein		ECO57		429	UniRef100_P0AB94
Arsenical pump membrane protein		SHIFL		429
Arsenical pump membrane protein		ECOLX		35
HTH 5 and ArsB domain containing protein		TRITR		548
Arsenical resistance operon repressor (Fragment)		human gut metagenome		71
+130

Protein	Similar proteins		Species	Score	Length	Source
P0AB93	Arsenical pump membrane protein		ECO57		429	UniRef90_P0AB94
Arsenical pump membrane protein		SHIFL		429
Arsenical pump membrane protein		ECOLX		35
HTH 5 and ArsB domain containing protein		TRITR		548
Arsenical resistance operon repressor (Fragment)		human gut metagenome		71
+154

Protein	Similar proteins		Species	Score	Length	Source
P0AB93	Arsenical pump membrane protein		ECO57		429	UniRef50_P0AB94
Arsenical pump membrane protein		SHIFL		429
Arsenical pump membrane protein		YEREN		429
Arsenical pump membrane protein		ECOLX		35
HTH 5 and ArsB domain containing protein		TRITR		548
+1209

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80057 Genomic DNA Translation: CAA56362.1 U00039 Genomic DNA Translation: AAB18478.1 Different initiation. U00096 Genomic DNA Translation: AAC76527.2 AP009048 Genomic DNA Translation: BAE77792.1
PIRⁱ	S47723
RefSeqⁱ	NP_417959.4, NC_000913.3 WP_000922639.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0AB93
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261325, 7 interactors
IntActⁱ	P0AB93, 1 interactor
STRINGⁱ	316385.ECDH10B_3678

Protein family/group databases

TCDBⁱ	3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

TCDBⁱ

3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

Proteomic databases

PaxDbⁱ	P0AB93
PRIDEⁱ	P0AB93

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76527; AAC76527; b3502 BAE77792; BAE77792; BAE77792
GeneIDⁱ	948011
KEGGⁱ	ecj:JW3469 eco:b3502
PATRICⁱ	fig\|511145.12.peg.3606

Organism-specific databases

EchoBASEⁱ	EB2148
EcoGeneⁱ	EG12236 arsB

Phylogenomic databases

eggNOGⁱ	ENOG4107R5R Bacteria COG1055 LUCA
HOGENOMⁱ	HOG000005271
InParanoidⁱ	P0AB93
KOⁱ	K03893
PhylomeDBⁱ	P0AB93

Enzyme and pathway databases

BioCycⁱ	EcoCyc:ARSF-MONOMER MetaCyc:ARSF-MONOMER

BioCycⁱ

EcoCyc:ARSF-MONOMER
MetaCyc:ARSF-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0AB93

PROⁱ

PR:P0AB93

Family and domain databases

CDDⁱ	cd01118 ArsB_permease, 1 hit
InterProⁱ	View protein in InterPro IPR000802 Arsenical_pump_ArsB
Pfamⁱ	View protein in Pfam PF02040 ArsB, 1 hit
PRINTSⁱ	PR00758 ARSENICPUMP
TIGRFAMsⁱ	TIGR00935 2a45, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARSB_ECOLI
Accessionⁱ	P0AB93Primary (citable) accession number: P0AB93 Secondary accession number(s): P37310, P76708, Q2M7G4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	November 8, 2005
	Last modified:	November 7, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0AB93 (ARSB_ECOLI)

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Arsenical pump membrane protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ