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Protein

Arsenical pump membrane protein

Gene

arsB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processArsenical resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ARSF-MONOMER
MetaCyc:ARSF-MONOMER

Protein family/group databases

TCDBi3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenical pump membrane protein
Alternative name(s):
Arsenic efflux pump protein
Gene namesi
Name:arsB
Synonyms:arsF
Ordered Locus Names:b3502, JW3469
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12236 arsB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 45PeriplasmicSequence analysis4
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 97CytoplasmicSequence analysisAdd BLAST31
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 120PeriplasmicSequence analysis2
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 177PeriplasmicSequence analysis5
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 227CytoplasmicSequence analysisAdd BLAST29
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 273CytoplasmicSequence analysis4
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 310PeriplasmicSequence analysisAdd BLAST16
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 406CytoplasmicSequence analysisAdd BLAST75
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 429PeriplasmicSequence analysis2

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002014671 – 429Arsenical pump membrane proteinAdd BLAST429

Proteomic databases

PaxDbiP0AB93
PRIDEiP0AB93

Interactioni

Protein-protein interaction databases

BioGridi4261325, 7 interactors
IntActiP0AB93, 1 interactor
STRINGi316385.ECDH10B_3678

Structurei

3D structure databases

ProteinModelPortaliP0AB93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107R5R Bacteria
COG1055 LUCA
HOGENOMiHOG000005271
InParanoidiP0AB93
KOiK03893
PhylomeDBiP0AB93

Family and domain databases

CDDicd01118 ArsB_permease, 1 hit
InterProiView protein in InterPro
IPR000802 Arsenical_pump_ArsB
PfamiView protein in Pfam
PF02040 ArsB, 1 hit
PRINTSiPR00758 ARSENICPUMP
TIGRFAMsiTIGR00935 2a45, 1 hit

Sequencei

Sequence statusi: Complete.

P0AB93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLAGAIFVL TIVLVIWQPK GLGIGWSATL GAVLALVTGV VHPGDIPVVW
60 70 80 90 100
NIVWNATAAF IAVIIISLLL DESGFFEWAA LHVSRWGNGR GRLLFTWIVL
110 120 130 140 150
LGAAVAALFA NDGAALILTP IVIAMLLALG FSKGTTLAFV MAAGFIADTA
160 170 180 190 200
SLPLIVSNLV NIVSADFFGL GFREYASVMV PVDIAAIVAT LVMLHLYFRK
210 220 230 240 250
DIPQNYDMAL LKSPAEAIKD PATFKTGWVV LLLLLVGFFV LEPLGIPVSA
260 270 280 290 300
IAAVGALILF VVAKRGHAIN TGKVLRGAPW QIVIFSLGMY LVVYGLRNAG
310 320 330 340 350
LTEYLSGVLN VLADNGLWAA TLGTGFLTAF LSSIMNNMPT VLVGALSIDG
360 370 380 390 400
STASGVIKEA MVYANVIGCD LGPKITPIGS LATLLWLHVL SQKNMTISWG
410 420
YYFRTGIIMT LPVLFVTLAA LALRLSFTL
Length:429
Mass (Da):45,497
Last modified:November 8, 2005 - v1
Checksum:i66EB1C03E479B6E9
GO

Sequence cautioni

The sequence AAB18478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA Translation: CAA56362.1
U00039 Genomic DNA Translation: AAB18478.1 Different initiation.
U00096 Genomic DNA Translation: AAC76527.2
AP009048 Genomic DNA Translation: BAE77792.1
PIRiS47723
RefSeqiNP_417959.4, NC_000913.3
WP_000922639.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76527; AAC76527; b3502
BAE77792; BAE77792; BAE77792
GeneIDi948011
KEGGiecj:JW3469
eco:b3502
PATRICifig|511145.12.peg.3606

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA Translation: CAA56362.1
U00039 Genomic DNA Translation: AAB18478.1 Different initiation.
U00096 Genomic DNA Translation: AAC76527.2
AP009048 Genomic DNA Translation: BAE77792.1
PIRiS47723
RefSeqiNP_417959.4, NC_000913.3
WP_000922639.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AB93
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261325, 7 interactors
IntActiP0AB93, 1 interactor
STRINGi316385.ECDH10B_3678

Protein family/group databases

TCDBi3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

Proteomic databases

PaxDbiP0AB93
PRIDEiP0AB93

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76527; AAC76527; b3502
BAE77792; BAE77792; BAE77792
GeneIDi948011
KEGGiecj:JW3469
eco:b3502
PATRICifig|511145.12.peg.3606

Organism-specific databases

EchoBASEiEB2148
EcoGeneiEG12236 arsB

Phylogenomic databases

eggNOGiENOG4107R5R Bacteria
COG1055 LUCA
HOGENOMiHOG000005271
InParanoidiP0AB93
KOiK03893
PhylomeDBiP0AB93

Enzyme and pathway databases

BioCyciEcoCyc:ARSF-MONOMER
MetaCyc:ARSF-MONOMER

Miscellaneous databases

PROiPR:P0AB93

Family and domain databases

CDDicd01118 ArsB_permease, 1 hit
InterProiView protein in InterPro
IPR000802 Arsenical_pump_ArsB
PfamiView protein in Pfam
PF02040 ArsB, 1 hit
PRINTSiPR00758 ARSENICPUMP
TIGRFAMsiTIGR00935 2a45, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARSB_ECOLI
AccessioniPrimary (citable) accession number: P0AB93
Secondary accession number(s): P37310, P76708, Q2M7G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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