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Entry version 98 (13 Feb 2019)
Sequence version 1 (08 Nov 2005)
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Protein

Arsenical pump membrane protein

Gene

arsB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processArsenical resistance, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:ARSF-MONOMER
ECOL316407:JW3469-MONOMER
MetaCyc:ARSF-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arsenical pump membrane protein
Alternative name(s):
Arsenic efflux pump protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arsB
Synonyms:arsF
Ordered Locus Names:b3502, JW3469
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG12236 arsB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 45PeriplasmicSequence analysis4
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 97CytoplasmicSequence analysisAdd BLAST31
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 120PeriplasmicSequence analysis2
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 177PeriplasmicSequence analysis5
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 227CytoplasmicSequence analysisAdd BLAST29
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 273CytoplasmicSequence analysis4
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 310PeriplasmicSequence analysisAdd BLAST16
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 406CytoplasmicSequence analysisAdd BLAST75
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 429PeriplasmicSequence analysis2

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002014671 – 429Arsenical pump membrane proteinAdd BLAST429

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AB93

PRoteomics IDEntifications database

More...
PRIDEi
P0AB93

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
4261325, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P0AB93, 1 interactor

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_3678

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0AB93

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ArsB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107R5R Bacteria
COG1055 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000005271

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AB93

KEGG Orthology (KO)

More...
KOi
K03893

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AB93

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01118 ArsB_permease, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000802 Arsenical_pump_ArsB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02040 ArsB, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00758 ARSENICPUMP

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00935 2a45, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AB93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLAGAIFVL TIVLVIWQPK GLGIGWSATL GAVLALVTGV VHPGDIPVVW
60 70 80 90 100
NIVWNATAAF IAVIIISLLL DESGFFEWAA LHVSRWGNGR GRLLFTWIVL
110 120 130 140 150
LGAAVAALFA NDGAALILTP IVIAMLLALG FSKGTTLAFV MAAGFIADTA
160 170 180 190 200
SLPLIVSNLV NIVSADFFGL GFREYASVMV PVDIAAIVAT LVMLHLYFRK
210 220 230 240 250
DIPQNYDMAL LKSPAEAIKD PATFKTGWVV LLLLLVGFFV LEPLGIPVSA
260 270 280 290 300
IAAVGALILF VVAKRGHAIN TGKVLRGAPW QIVIFSLGMY LVVYGLRNAG
310 320 330 340 350
LTEYLSGVLN VLADNGLWAA TLGTGFLTAF LSSIMNNMPT VLVGALSIDG
360 370 380 390 400
STASGVIKEA MVYANVIGCD LGPKITPIGS LATLLWLHVL SQKNMTISWG
410 420
YYFRTGIIMT LPVLFVTLAA LALRLSFTL
Length:429
Mass (Da):45,497
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66EB1C03E479B6E9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB18478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X80057 Genomic DNA Translation: CAA56362.1
U00039 Genomic DNA Translation: AAB18478.1 Different initiation.
U00096 Genomic DNA Translation: AAC76527.2
AP009048 Genomic DNA Translation: BAE77792.1

Protein sequence database of the Protein Information Resource

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PIRi
S47723

NCBI Reference Sequences

More...
RefSeqi
NP_417959.4, NC_000913.3
WP_000922639.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76527; AAC76527; b3502
BAE77792; BAE77792; BAE77792

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948011

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3469
eco:b3502

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.3606

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA Translation: CAA56362.1
U00039 Genomic DNA Translation: AAB18478.1 Different initiation.
U00096 Genomic DNA Translation: AAC76527.2
AP009048 Genomic DNA Translation: BAE77792.1
PIRiS47723
RefSeqiNP_417959.4, NC_000913.3
WP_000922639.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AB93
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261325, 7 interactors
IntActiP0AB93, 1 interactor
STRINGi316385.ECDH10B_3678

Protein family/group databases

TCDBi3.A.4.1.1 the arsenite-antimonite (arsab) efflux family

Proteomic databases

PaxDbiP0AB93
PRIDEiP0AB93

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76527; AAC76527; b3502
BAE77792; BAE77792; BAE77792
GeneIDi948011
KEGGiecj:JW3469
eco:b3502
PATRICifig|511145.12.peg.3606

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2148
EcoGeneiEG12236 arsB

Phylogenomic databases

eggNOGiENOG4107R5R Bacteria
COG1055 LUCA
HOGENOMiHOG000005271
InParanoidiP0AB93
KOiK03893
PhylomeDBiP0AB93

Enzyme and pathway databases

BioCyciEcoCyc:ARSF-MONOMER
ECOL316407:JW3469-MONOMER
MetaCyc:ARSF-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AB93

Family and domain databases

CDDicd01118 ArsB_permease, 1 hit
InterProiView protein in InterPro
IPR000802 Arsenical_pump_ArsB
PfamiView protein in Pfam
PF02040 ArsB, 1 hit
PRINTSiPR00758 ARSENICPUMP
TIGRFAMsiTIGR00935 2a45, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARSB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AB93
Secondary accession number(s): P37310, P76708, Q2M7G4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: February 13, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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