UniProtKB - P0AB93 (ARSB_ECOLI)
Protein
Arsenical pump membrane protein
Gene
arsB
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity).By similarity
GO - Molecular functioni
- antimonite secondary active transmembrane transporter activity Source: EcoCyc
- arsenite secondary active transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- antimonite transport Source: EcoCyc
- arsenite transport Source: EcoCyc
- response to arsenic-containing substance Source: UniProtKB-KW
Keywordsi
Biological process | Arsenical resistance, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:ARSF-MONOMER MetaCyc:ARSF-MONOMER |
Protein family/group databases
TCDBi | 3.A.4.1.1, the arsenite-antimonite (arsab) efflux family |
Names & Taxonomyi
Protein namesi | Recommended name: Arsenical pump membrane proteinAlternative name(s): Arsenic efflux pump protein |
Gene namesi | Name:arsB Synonyms:arsF Ordered Locus Names:b3502, JW3469 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoliWiki
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 42 – 45 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 46 – 66 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 67 – 97 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 120 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 142 – 151 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 173 – 177 | PeriplasmicSequence analysis | 5 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 199 – 227 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 228 – 248 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 249 – 269 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 270 – 273 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 274 – 294 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 295 – 310 | PeriplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 311 – 331 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 332 – 406 | CytoplasmicSequence analysisAdd BLAST | 75 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 429 | PeriplasmicSequence analysis | 2 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201467 | 1 – 429 | Arsenical pump membrane proteinAdd BLAST | 429 |
Proteomic databases
PaxDbi | P0AB93 |
PRIDEi | P0AB93 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261325, 7 interactors |
IntActi | P0AB93, 1 interactor |
STRINGi | 511145.b3502 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ArsB family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1055, Bacteria |
HOGENOMi | CLU_043931_1_0_6 |
InParanoidi | P0AB93 |
PhylomeDBi | P0AB93 |
Family and domain databases
CDDi | cd01118, ArsB_permease, 1 hit |
InterProi | View protein in InterPro IPR000802, Arsenical_pump_ArsB |
Pfami | View protein in Pfam PF02040, ArsB, 1 hit |
PRINTSi | PR00758, ARSENICPUMP |
TIGRFAMsi | TIGR00935, 2a45, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AB93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLAGAIFVL TIVLVIWQPK GLGIGWSATL GAVLALVTGV VHPGDIPVVW
60 70 80 90 100
NIVWNATAAF IAVIIISLLL DESGFFEWAA LHVSRWGNGR GRLLFTWIVL
110 120 130 140 150
LGAAVAALFA NDGAALILTP IVIAMLLALG FSKGTTLAFV MAAGFIADTA
160 170 180 190 200
SLPLIVSNLV NIVSADFFGL GFREYASVMV PVDIAAIVAT LVMLHLYFRK
210 220 230 240 250
DIPQNYDMAL LKSPAEAIKD PATFKTGWVV LLLLLVGFFV LEPLGIPVSA
260 270 280 290 300
IAAVGALILF VVAKRGHAIN TGKVLRGAPW QIVIFSLGMY LVVYGLRNAG
310 320 330 340 350
LTEYLSGVLN VLADNGLWAA TLGTGFLTAF LSSIMNNMPT VLVGALSIDG
360 370 380 390 400
STASGVIKEA MVYANVIGCD LGPKITPIGS LATLLWLHVL SQKNMTISWG
410 420
YYFRTGIIMT LPVLFVTLAA LALRLSFTL
Sequence cautioni
The sequence AAB18478 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80057 Genomic DNA Translation: CAA56362.1 U00039 Genomic DNA Translation: AAB18478.1 Different initiation. U00096 Genomic DNA Translation: AAC76527.2 AP009048 Genomic DNA Translation: BAE77792.1 |
PIRi | S47723 |
RefSeqi | NP_417959.4, NC_000913.3 WP_000922639.1, NZ_SSZK01000042.1 |
Genome annotation databases
EnsemblBacteriai | AAC76527; AAC76527; b3502 BAE77792; BAE77792; BAE77792 |
GeneIDi | 58391092 948011 |
KEGGi | ecj:JW3469 eco:b3502 |
PATRICi | fig|511145.12.peg.3606 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80057 Genomic DNA Translation: CAA56362.1 U00039 Genomic DNA Translation: AAB18478.1 Different initiation. U00096 Genomic DNA Translation: AAC76527.2 AP009048 Genomic DNA Translation: BAE77792.1 |
PIRi | S47723 |
RefSeqi | NP_417959.4, NC_000913.3 WP_000922639.1, NZ_SSZK01000042.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261325, 7 interactors |
IntActi | P0AB93, 1 interactor |
STRINGi | 511145.b3502 |
Protein family/group databases
TCDBi | 3.A.4.1.1, the arsenite-antimonite (arsab) efflux family |
Proteomic databases
PaxDbi | P0AB93 |
PRIDEi | P0AB93 |
Genome annotation databases
EnsemblBacteriai | AAC76527; AAC76527; b3502 BAE77792; BAE77792; BAE77792 |
GeneIDi | 58391092 948011 |
KEGGi | ecj:JW3469 eco:b3502 |
PATRICi | fig|511145.12.peg.3606 |
Organism-specific databases
EchoBASEi | EB2148 |
Phylogenomic databases
eggNOGi | COG1055, Bacteria |
HOGENOMi | CLU_043931_1_0_6 |
InParanoidi | P0AB93 |
PhylomeDBi | P0AB93 |
Enzyme and pathway databases
BioCyci | EcoCyc:ARSF-MONOMER MetaCyc:ARSF-MONOMER |
Miscellaneous databases
PROi | PR:P0AB93 |
Family and domain databases
CDDi | cd01118, ArsB_permease, 1 hit |
InterProi | View protein in InterPro IPR000802, Arsenical_pump_ArsB |
Pfami | View protein in Pfam PF02040, ArsB, 1 hit |
PRINTSi | PR00758, ARSENICPUMP |
TIGRFAMsi | TIGR00935, 2a45, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARSB_ECOLI | |
Accessioni | P0AB93Primary (citable) accession number: P0AB93 Secondary accession number(s): P37310, P76708, Q2M7G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families