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UniProtKB - P0AB67 (PNTB_ECOLI)

Entry version 108 (13 Nov 2019)
Sequence version 1 (08 Nov 2005)
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Protein

NAD(P) transhydrogenase subunit beta

Gene

pntB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • NADPH regeneration Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandNAD, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:PNTB-MONOMER
ECOL316407:JW1594-MONOMER
MetaCyc:PNTB-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		3.D.2.1.1 the proton-translocating transhydrogenase (pth) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD(P) transhydrogenase subunit beta (EC:7.1.1.1)
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit beta
Pyridine nucleotide transhydrogenase subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pntB
Ordered Locus Names:b1602, JW1594
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3PeriplasmicSequence analysis3
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 45CytoplasmicSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 82PeriplasmicSequence analysisAdd BLAST16
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 115CytoplasmicSequence analysisAdd BLAST12
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 164PeriplasmicSequence analysisAdd BLAST28
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 188CytoplasmicSequence analysis3
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 215PeriplasmicSequence analysis6
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 239CytoplasmicSequence analysis3
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 308PeriplasmicSequence analysisAdd BLAST48
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 462CytoplasmicSequence analysisAdd BLAST133

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001990231 – 462NAD(P) transhydrogenase subunit betaAdd BLAST462

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0AB67

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0AB67

PRoteomics IDEntifications database

More...PRIDEi		P0AB67

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4259125, 34 interactors

Database of interacting proteins

More...DIPi		DIP-367N

STRING: functional protein association networks

More...STRINGi		511145.b1602

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0AB67

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P0AB67

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PNT beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105C15 Bacteria
COG1282 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000243958

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0AB67

KEGG Orthology (KO)

More...KOi		K00325

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0AB67

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR012136 NADH_DH_b
IPR034300 PNTB-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02233 PNTB, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000204 PNTB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52467 SSF52467, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AB67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGLVTAAY IVAAILFIFS LAGLSKHETS RQGNNFGIAG MAIALIATIF 
        60         70         80         90        100
GPDTGNVGWI LLAMVIGGAI GIRLAKKVEM TEMPELVAIL HSFVGLAAVL 
       110        120        130        140        150
VGFNSYLHHD AGMAPILVNI HLTEVFLGIF IGAVTFTGSV VAFGKLCGKI 
       160        170        180        190        200
SSKPLMLPNR HKMNLAALVV SFLLLIVFVR TDSVGLQVLA LLIMTAIALV 
       210        220        230        240        250
FGWHLVASIG GADMPVVVSM LNSYSGWAAA AAGFMLSNDL LIVTGALVGS 
       260        270        280        290        300
SGAILSYIMC KAMNRSFISV IAGGFGTDGS STGDDQEVGE HREITAEETA 
       310        320        330        340        350
ELLKNSHSVI ITPGYGMAVA QAQYPVAEIT EKLRARGINV RFGIHPVAGR 
       360        370        380        390        400
LPGHMNVLLA EAKVPYDIVL EMDEINDDFA DTDTVLVIGA NDTVNPAAQD 
       410        420        430        440        450
DPKSPIAGMP VLEVWKAQNV IVFKRSMNTG YAGVQNPLFF KENTHMLFGD 
       460 
AKASVDAILK AL
Length:462
Mass (Da):48,723
Last modified:November 8, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD11747291D271A2F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X04195 Genomic DNA Translation: CAB37090.1
X66086 Genomic DNA Translation: CAA46885.1
U00096 Genomic DNA Translation: AAC74674.1
AP009048 Genomic DNA Translation: BAA15336.1

Protein sequence database of the Protein Information Resource

More...PIRi		S24381 DEECXB

NCBI Reference Sequences

More...RefSeqi		NP_416119.1, NC_000913.3
WP_000014036.1, NZ_STEB01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74674; AAC74674; b1602
BAA15336; BAA15336; BAA15336

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1594
eco:b1602

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.660

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04195 Genomic DNA Translation: CAB37090.1
X66086 Genomic DNA Translation: CAA46885.1
U00096 Genomic DNA Translation: AAC74674.1
AP009048 Genomic DNA Translation: BAA15336.1
PIRiS24381 DEECXB
RefSeqiNP_416119.1, NC_000913.3
WP_000014036.1, NZ_STEB01000003.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BRUNMR-C286-462[»]
SMRiP0AB67
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4259125, 34 interactors
DIPiDIP-367N
STRINGi511145.b1602

Protein family/group databases

TCDBi3.D.2.1.1 the proton-translocating transhydrogenase (pth) family

Proteomic databases

jPOSTiP0AB67
PaxDbiP0AB67
PRIDEiP0AB67

Genome annotation databases

EnsemblBacteriaiAAC74674; AAC74674; b1602
BAA15336; BAA15336; BAA15336
GeneIDi946144
KEGGiecj:JW1594
eco:b1602
PATRICifig|1411691.4.peg.660

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0738

Phylogenomic databases

eggNOGiENOG4105C15 Bacteria
COG1282 LUCA
HOGENOMiHOG000243958
InParanoidiP0AB67
KOiK00325
PhylomeDBiP0AB67

Enzyme and pathway databases

BioCyciEcoCyc:PNTB-MONOMER
ECOL316407:JW1594-MONOMER
MetaCyc:PNTB-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0AB67

Protein Ontology

More...PROi		PR:P0AB67

Family and domain databases

InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR012136 NADH_DH_b
IPR034300 PNTB-like
PfamiView protein in Pfam
PF02233 PNTB, 1 hit
PIRSFiPIRSF000204 PNTB, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNTB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AB67
Secondary accession number(s): P07002, P76890
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 8, 2005
Last modified: November 13, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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