UniProtKB - P0AB40 (BHSA_ECOLI)
Protein
Multiple stress resistance protein BhsA
Gene
bhsA
Organism
Escherichia coli (strain K12)
Status
Functioni
Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction.2 Publications
GO - Biological processi
- response to copper ion Source: EcoCyc
Keywordsi
Biological process | Stress response |
Ligand | Copper |
Enzyme and pathway databases
BioCyci | EcoCyc:G6570-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Multiple stress resistance protein BhsAAlternative name(s): Copper-induced outer membrane component |
Gene namesi | Name:bhsA Synonyms:comC, ycfR Ordered Locus Names:b1112, JW1098 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
- Cell outer membrane 1 Publication
Other locations
- cell outer membrane Source: EcoCyc
Keywords - Cellular componenti
Cell outer membrane, MembranePathology & Biotechi
Disruption phenotypei
Disruption of this gene increases copper sensitivity, induces stress response genes in biofilms, increases aggregation and cell surface hydrophobicity, and decreases indole synthesis.2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000013825 | 23 – 85 | Multiple stress resistance protein BhsAAdd BLAST | 63 |
Proteomic databases
PaxDbi | P0AB40 |
PRIDEi | P0AB40 |
Expressioni
Inductioni
Repressed by ComR. Induced by copper via release of ComR. Induced in biofilms and by several stress conditions.2 Publications
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261348, 15 interactors |
DIPi | DIP-48158N |
STRINGi | 511145.b1112 |
Family & Domainsi
Sequence similaritiesi
Belongs to the BhsA/McbA family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG5032ZBU, Bacteria |
HOGENOMi | CLU_158602_2_3_6 |
PhylomeDBi | P0AB40 |
Family and domain databases
Gene3Di | 3.30.1660.10, 1 hit |
InterProi | View protein in InterPro IPR025543, Dodecin-like IPR010854, DUF1471 IPR036275, YdgH-like_sf |
Pfami | View protein in Pfam PF07338, DUF1471, 1 hit |
SUPFAMi | SSF159871, SSF159871, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AB40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNVKTLIAA AILSSMSFAS FAAVEVQSTP EGQQKVGTIS ANAGTNLGSL
60 70 80
EEQLAQKADE MGAKSFRITS VTGPNTLHGT AVIYK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74196.1 AP009048 Genomic DNA Translation: BAA35927.1 |
PIRi | E64855 |
RefSeqi | NP_415630.1, NC_000913.3 WP_000800153.1, NZ_STEB01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC74196; AAC74196; b1112 BAA35927; BAA35927; BAA35927 |
GeneIDi | 58461232 945492 |
KEGGi | ecj:JW1098 eco:b1112 |
PATRICi | fig|1411691.4.peg.1155 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74196.1 AP009048 Genomic DNA Translation: BAA35927.1 |
PIRi | E64855 |
RefSeqi | NP_415630.1, NC_000913.3 WP_000800153.1, NZ_STEB01000016.1 |
3D structure databases
SMRi | P0AB40 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261348, 15 interactors |
DIPi | DIP-48158N |
STRINGi | 511145.b1112 |
Proteomic databases
PaxDbi | P0AB40 |
PRIDEi | P0AB40 |
Genome annotation databases
EnsemblBacteriai | AAC74196; AAC74196; b1112 BAA35927; BAA35927; BAA35927 |
GeneIDi | 58461232 945492 |
KEGGi | ecj:JW1098 eco:b1112 |
PATRICi | fig|1411691.4.peg.1155 |
Organism-specific databases
EchoBASEi | EB3210 |
Phylogenomic databases
eggNOGi | ENOG5032ZBU, Bacteria |
HOGENOMi | CLU_158602_2_3_6 |
PhylomeDBi | P0AB40 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6570-MONOMER |
Miscellaneous databases
PROi | PR:P0AB40 |
Family and domain databases
Gene3Di | 3.30.1660.10, 1 hit |
InterProi | View protein in InterPro IPR025543, Dodecin-like IPR010854, DUF1471 IPR036275, YdgH-like_sf |
Pfami | View protein in Pfam PF07338, DUF1471, 1 hit |
SUPFAMi | SSF159871, SSF159871, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BHSA_ECOLI | |
Accessioni | P0AB40Primary (citable) accession number: P0AB40 Secondary accession number(s): P75953 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families