UniProtKB - P0AB01 (ELYC_ECOLI)
Protein
Envelope biogenesis factor ElyC
Gene
elyC
Organism
Escherichia coli (strain K12)
Status
Functioni
Plays a critical role in the metabolism of the essential lipid carrier used for cell wall synthesis.1 Publication
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- Gram-negative-bacterium-type cell wall biogenesis Source: EcoCyc
- peptidoglycan metabolic process Source: EcoCyc
- protein folding Source: EcoCyc
Keywordsi
Biological process | Cell wall biogenesis/degradation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12166-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Envelope biogenesis factor ElyCAlternative name(s): Elevated frequency of lysis |
Gene namesi | Name:elyC Synonyms:ycbC Ordered Locus Names:b0920, JW0903 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane Curated; Multi-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Deletion causes a severe growth defect at low temperature and an elevated frequency of cell lysis resulting from impaired metabolism of the essential lipid precursor required for peptidoglycan synthesis.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168768 | 1 – 259 | Envelope biogenesis factor ElyCAdd BLAST | 259 |
Proteomic databases
jPOSTi | P0AB01 |
PaxDbi | P0AB01 |
PRIDEi | P0AB01 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263426, 298 interactors 849920, 2 interactors |
IntActi | P0AB01, 3 interactors |
STRINGi | 511145.b0920 |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1434, Bacteria |
HOGENOMi | CLU_053514_0_0_6 |
InParanoidi | P0AB01 |
PhylomeDBi | P0AB01 |
Family and domain databases
CDDi | cd06259, YdcF-like, 1 hit |
InterProi | View protein in InterPro IPR003848, DUF218 |
Pfami | View protein in Pfam PF02698, DUF218, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AB01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFTLKKVIG NMLLPLPLML LIIGAGLALL WFSRFQKTGK IFISIGWLAL
60 70 80 90 100
LLLSLQPVAD RLLRPIESTY PTWNNSQKVD YIVVLGGGYT WNPQWAPSSN
110 120 130 140 150
LINNSLPRLN EGIRLWRENP GSKLIFTGGV AKTNTVSTAE VGARVAQSLG
160 170 180 190 200
VPREQIITLD LPKDTEEEAA AVKQAIGDAP FLLVTSASHL PRAMIFFQQE
210 220 230 240 250
GLNPLPAPAN QLAIDSPLNP WERAIPSPVW LMHSDRVGYE TLGRIWQWLK
GSSGEPRQE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 89 | Y → N in D26440 (PubMed:7513784).Curated | 1 | |
Sequence conflicti | 150 – 170 | GVPRE…EEEAA → ACRASKLSPWICQKIPKKKL Q in D26440 (PubMed:7513784).CuratedAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74006.1 AP009048 Genomic DNA Translation: BAA35666.1 D26440 Genomic DNA No translation available. |
PIRi | G64831 |
RefSeqi | NP_415440.1, NC_000913.3 WP_000899600.1, NZ_SSZK01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC74006; AAC74006; b0920 BAA35666; BAA35666; BAA35666 |
GeneIDi | 945546 |
KEGGi | ecj:JW0903 eco:b0920 |
PATRICi | fig|511145.12.peg.951 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74006.1 AP009048 Genomic DNA Translation: BAA35666.1 D26440 Genomic DNA No translation available. |
PIRi | G64831 |
RefSeqi | NP_415440.1, NC_000913.3 WP_000899600.1, NZ_SSZK01000002.1 |
3D structure databases
SMRi | P0AB01 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263426, 298 interactors 849920, 2 interactors |
IntActi | P0AB01, 3 interactors |
STRINGi | 511145.b0920 |
Proteomic databases
jPOSTi | P0AB01 |
PaxDbi | P0AB01 |
PRIDEi | P0AB01 |
Genome annotation databases
EnsemblBacteriai | AAC74006; AAC74006; b0920 BAA35666; BAA35666; BAA35666 |
GeneIDi | 945546 |
KEGGi | ecj:JW0903 eco:b0920 |
PATRICi | fig|511145.12.peg.951 |
Organism-specific databases
EchoBASEi | EB2085 |
Phylogenomic databases
eggNOGi | COG1434, Bacteria |
HOGENOMi | CLU_053514_0_0_6 |
InParanoidi | P0AB01 |
PhylomeDBi | P0AB01 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12166-MONOMER |
Miscellaneous databases
PROi | PR:P0AB01 |
Family and domain databases
CDDi | cd06259, YdcF-like, 1 hit |
InterProi | View protein in InterPro IPR003848, DUF218 |
Pfami | View protein in Pfam PF02698, DUF218, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELYC_ECOLI | |
Accessioni | P0AB01Primary (citable) accession number: P0AB01 Secondary accession number(s): P36565, P75846 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | October 7, 2020 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |