Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate hydrogenlyase subunit 2

Gene

hycB

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable electron transfer protein for hydrogenase 3.By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi15Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi18Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi22Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi51Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi54Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi59Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi63Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi82Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi85Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi88Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi92Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi143Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi146Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi155Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi159Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Protein family/group databases

TCDBi3.D.1.9.2 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Formate hydrogenlyase subunit 2
Short name:
FHL subunit 2
Alternative name(s):
Hydrogenase-3 component B
Gene namesi
Name:hycB
Ordered Locus Names:SF2741, S2933
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592651 – 203Formate hydrogenlyase subunit 2Add BLAST203

Interactioni

Subunit structurei

FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP0AAK3
SMRiP0AAK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 324Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini42 – 724Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST31
Domaini73 – 1024Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini137 – 1694Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108MFN Bacteria
COG1142 LUCA
HOGENOMiHOG000163385
KOiK15827
OMAiRTCPTKA

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
PfamiView protein in Pfam
PF13247 Fer4_11, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 4 hits

Sequencei

Sequence statusi: Complete.

P0AAK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRFVIADST LCIGCHTCEA ACSETHRQHG LQSMPRLRVM LNEKESAPQL
60 70 80 90 100
CHHCEDAPCA VVCPVNAITR VDGAVQLNES LCVSCKLCGI ACPFGAIEFS
110 120 130 140 150
GSRPLDIPAN ANTPKAPPAP PAPARVSTLL DWVPGIRAIA VKCDLCSFDE
160 170 180 190 200
QGPACVRMCP TKALHLVDNT DIARVSKRKR ELTFNTDFGD LTLFQQAQSG

EAK
Length:203
Mass (Da):21,873
Last modified:October 11, 2005 - v1
Checksum:i828042E504B00DBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN44232.1
AE014073 Genomic DNA Translation: AAP18059.1
RefSeqiNP_708525.1, NC_004337.2
WP_001079186.1, NZ_PUGL01000137.1

Genome annotation databases

EnsemblBacteriaiAAN44232; AAN44232; SF2741
AAP18059; AAP18059; S2933
GeneIDi1025711
KEGGisfl:SF2741
sfx:S2933
PATRICifig|198214.7.peg.3264

Similar proteinsi

Entry informationi

Entry nameiHYCB_SHIFL
AccessioniPrimary (citable) accession number: P0AAK3
Secondary accession number(s): P16428, Q46883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 18, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again