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Protein

Formate dehydrogenase-O iron-sulfur subunit

Gene

fdoH

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi42Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi45Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi49Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi100Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi103Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi108Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi112Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi133Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi136Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi139Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi143Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi160Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi163Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi175Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi179Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciECOL199310:C4843-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase-O iron-sulfur subunit
Alternative name(s):
Aerobic formate dehydrogenase iron-sulfur subunit
FDH-Z subunit beta
Formate dehydrogenase-O subunit beta
Gene namesi
Name:fdoH
Ordered Locus Names:c4843
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 260CytoplasmicCuratedAdd BLAST260
Transmembranei261 – 279HelicalCuratedAdd BLAST19
Topological domaini280 – 300PeriplasmicCuratedAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592501 – 300Formate dehydrogenase-O iron-sulfur subunitAdd BLAST300

Proteomic databases

PRIDEiP0AAJ6

Interactioni

Subunit structurei

Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma.By similarity

Protein-protein interaction databases

STRINGi199310.c4843

Structurei

3D structure databases

ProteinModelPortaliP0AAJ6
SMRiP0AAJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 604Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini91 – 1234Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST33
Domaini124 – 1534Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini158 – 1894Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105QA4 Bacteria
COG0437 LUCA
HOGENOMiHOG000163382
KOiK00124
OMAiKACQSAC

Family and domain databases

CDDicd10558 FDH-N, 1 hit
Gene3Di1.20.5.480, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR006470 Formate_DH_bsu_Proteobacteria
IPR038384 Formate_DH_C_sf
IPR014603 Formate_DH_Fe-S_su
IPR015246 Formate_DH_TM
PfamiView protein in Pfam
PF13247 Fer4_11, 1 hit
PF09163 Form-deh_trans, 1 hit
PIRSFiPIRSF036298 FDH_4Fe4S, 1 hit
TIGRFAMsiTIGR01582 FDH-beta, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 4 hits

Sequencei

Sequence statusi: Complete.

P0AAJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYQSQDIIR RSATNGLTPA PQARDFQEEV AKLIDVTTCI GCKACQVACS
60 70 80 90 100
EWNDIRDTVG NNIGVYDNPN DLSAKSWTVM RFSEVEQNDK LEWLIRKDGC
110 120 130 140 150
MHCSDPGCLK ACPAEGAIIQ YANGIVDFQS EQCIGCGYCI AGCPFDIPRL
160 170 180 190 200
NPEDNRVYKC TLCVDRVVVG QEPACVKTCP TGAIHFGTKE SMKTLASERV
210 220 230 240 250
AELKTRGYDN AGLYDPAGVG GTHVMYVLHH ADKPNLYHGL PENPEISETV
260 270 280 290 300
KFWKGIWKPL AAVGFAATFA ASIFHYVGVG PNRADEEENN LHEEKDEERK
Length:300
Mass (Da):33,100
Last modified:October 11, 2005 - v1
Checksum:i950B40FE1A6016E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA Translation: AAN83272.1
RefSeqiWP_000331377.1, NC_004431.1

Genome annotation databases

EnsemblBacteriaiAAN83272; AAN83272; c4843
KEGGiecc:c4843

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA Translation: AAN83272.1
RefSeqiWP_000331377.1, NC_004431.1

3D structure databases

ProteinModelPortaliP0AAJ6
SMRiP0AAJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c4843

Proteomic databases

PRIDEiP0AAJ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN83272; AAN83272; c4843
KEGGiecc:c4843

Phylogenomic databases

eggNOGiENOG4105QA4 Bacteria
COG0437 LUCA
HOGENOMiHOG000163382
KOiK00124
OMAiKACQSAC

Enzyme and pathway databases

BioCyciECOL199310:C4843-MONOMER

Family and domain databases

CDDicd10558 FDH-N, 1 hit
Gene3Di1.20.5.480, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR006470 Formate_DH_bsu_Proteobacteria
IPR038384 Formate_DH_C_sf
IPR014603 Formate_DH_Fe-S_su
IPR015246 Formate_DH_TM
PfamiView protein in Pfam
PF13247 Fer4_11, 1 hit
PF09163 Form-deh_trans, 1 hit
PIRSFiPIRSF036298 FDH_4Fe4S, 1 hit
TIGRFAMsiTIGR01582 FDH-beta, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFDOH_ECOL6
AccessioniPrimary (citable) accession number: P0AAJ6
Secondary accession number(s): P32175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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