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UniProtKB - P0AAI8 (FABF_SHIFL)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
fabF
Organism
Shigella flexneri
Status
Functioni
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
By similarityCatalytic activityi
- (9Z)-hexadecenoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]By similarityEC:2.3.1.179By similarity
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 164 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179By similarity)Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase II Beta-ketoacyl-ACP synthase II Short name: KAS II |
Gene namesi | Name:fabF Ordered Locus Names:SF1099, S1179 |
Organismi | Shigella flexneri |
Taxonomic identifieri | 623 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000180318 | 2 – 413 | 3-oxoacyl-[acyl-carrier-protein] synthase 2Add BLAST | 412 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 198214.SF1099 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_000022_69_2_6 |
OMAi | QIGHCLG |
OrthoDBi | 606297at2 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AAI8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKRRVVVTG LGMLSPVGNT VESTWKALLA GQSGISLIDH FDTSAYATKF
60 70 80 90 100
AGLVKDFNCE DIISRKEQRK MDAFIQYGIV AGVQAMQDSG LEITEENATR
110 120 130 140 150
IGAAIGSGIG GLGLIEENHT SLMNGGPRKI SPFFVPSTIV NMVAGHLTIM
160 170 180 190 200
YGLRGPSISI ATACTSGVHN IGHAARIIAY GDADVMVAGG AEKASTPLGV
210 220 230 240 250
GGFGAARALS TRNDNPQAAS RPWDKERDGF VLGDGAGMLV LEEYEHAKKR
260 270 280 290 300
GAKIYAELVG FGMSSDAYHM TSPPENGAGA ALAMANALRD AGIEASQIGY
310 320 330 340 350
VNAHGTSTPA GDKAEAQAVK TIFGEAASRV LVSSTKSMTG HLLGAAGAVE
360 370 380 390 400
SIYSILALRD QAVPPTINLD NPDEGCDLDF VPHEARQVSG MEYTLCNSFG
410
FGGTNGSLIF KKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN42718.1 AE014073 Genomic DNA Translation: AAP16606.1 |
RefSeqi | NP_707011.1, NC_004337.2 WP_000044679.1, NZ_UIQL01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAN42718; AAN42718; SF1099 AAP16606; AAP16606; S1179 |
GeneIDi | 1024036 67414288 |
KEGGi | sfl:SF1099 sfx:S1179 |
PATRICi | fig|198214.7.peg.1287 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN42718.1 AE014073 Genomic DNA Translation: AAP16606.1 |
RefSeqi | NP_707011.1, NC_004337.2 WP_000044679.1, NZ_UIQL01000002.1 |
3D structure databases
SMRi | P0AAI8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 198214.SF1099 |
Genome annotation databases
EnsemblBacteriai | AAN42718; AAN42718; SF1099 AAP16606; AAP16606; S1179 |
GeneIDi | 1024036 67414288 |
KEGGi | sfl:SF1099 sfx:S1179 |
PATRICi | fig|198214.7.peg.1287 |
Phylogenomic databases
HOGENOMi | CLU_000022_69_2_6 |
OMAi | QIGHCLG |
OrthoDBi | 606297at2 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABF_SHIFL | |
Accessioni | P0AAI8Primary (citable) accession number: P0AAI8 Secondary accession number(s): P39435 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families