UniProtKB - P0AAG8 (MGLA_ECOLI)
Protein
Galactose/methyl galactoside import ATP-binding protein MglA
Gene
mglA
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable).3 Publications
Catalytic activityi
- EC:7.5.2.11UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 46 – 53 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled carbohydrate transmembrane transporter activity Source: InterPro
- ATP binding Source: EcoCyc
- galactose transmembrane transporter activity Source: EcoCyc
- methylgalactoside transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- galactose transmembrane transport Source: EcoCyc
- methylgalactoside transport Source: EcoCyc
Keywordsi
Molecular function | Translocase |
Biological process | Sugar transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:MGLA-MONOMER MetaCyc:MGLA-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.2.3, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Galactose/methyl galactoside import ATP-binding protein MglAUniRule annotation (EC:7.5.2.11UniRule annotation) |
Gene namesi | Name:mglAUniRule annotation Ordered Locus Names:b2149, JW2136 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092512 | 1 – 506 | Galactose/methyl galactoside import ATP-binding protein MglAAdd BLAST | 506 |
Proteomic databases
jPOSTi | P0AAG8 |
PaxDbi | P0AAG8 |
PRIDEi | P0AAG8 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).
UniRule annotationProtein-protein interaction databases
BioGRIDi | 4260868, 26 interactors 853280, 6 interactors |
ComplexPortali | CPX-4341, Beta-methyl-D-galactoside/galactose ABC transporter complex |
IntActi | P0AAG8, 13 interactors |
STRINGi | 511145.b2149 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 249 | ABC transporter 1UniRule annotationAdd BLAST | 236 | |
Domaini | 264 – 506 | ABC transporter 2UniRule annotationAdd BLAST | 243 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family. [View classification]UniRule annotation
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | COG1129, Bacteria |
HOGENOMi | CLU_000604_92_3_6 |
InParanoidi | P0AAG8 |
PhylomeDBi | P0AAG8 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015862, ABC_transpr_MglA IPR027417, P-loop_NTPase |
PANTHERi | PTHR43790:SF7, PTHR43790:SF7, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits PS51260, MGLA, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AAG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSSTTPSSG EYLLEMSGIN KSFPGVKALD NVNLKVRPHS IHALMGENGA
60 70 80 90 100
GKSTLLKCLF GIYQKDSGTI LFQGKEIDFH SAKEALENGI SMVHQELNLV
110 120 130 140 150
LQRSVMDNMW LGRYPTKGMF VDQDKMYRET KAIFDELDID IDPRARVGTL
160 170 180 190 200
SVSQMQMIEI AKAFSYNAKI VIMDEPTSSL TEKEVNHLFT IIRKLKERGC
210 220 230 240 250
GIVYISHKME EIFQLCDEVT VLRDGQWIAT EPLAGLTMDK IIAMMVGRSL
260 270 280 290 300
NQRFPDKENK PGEVILEVRN LTSLRQPSIR DVSFDLHKGE ILGIAGLVGA
310 320 330 340 350
KRTDIVETLF GIREKSAGTI TLHGKQINNH NANEAINHGF ALVTEERRST
360 370 380 390 400
GIYAYLDIGF NSLISNIRNY KNKVGLLDNS RMKSDTQWVI DSMRVKTPGH
410 420 430 440 450
RTQIGSLSGG NQQKVIIGRW LLTQPEILML DEPTRGIDVG AKFEIYQLIA
460 470 480 490 500
ELAKKGKGII IISSEMPELL GITDRILVMS NGLVSGIVDT KTTTQNEILR
LASLHL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 – 69 | KCLFG…KDSGT → NACLVFIKRLRH (PubMed:3302609).CuratedAdd BLAST | 13 | |
Sequence conflicti | 163 | A → G in AAA24170 (PubMed:9278503).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59444 Genomic DNA Translation: AAA24170.1 U00096 Genomic DNA Translation: AAC75210.1 AP009048 Genomic DNA Translation: BAE76626.1 X05646 Genomic DNA Translation: CAA29133.1 |
PIRi | D64983 |
RefSeqi | NP_416654.1, NC_000913.3 WP_000255039.1, NZ_SSZK01000011.1 |
Genome annotation databases
EnsemblBacteriai | AAC75210; AAC75210; b2149 BAE76626; BAE76626; BAE76626 |
GeneIDi | 58388968 949036 |
KEGGi | ecj:JW2136 eco:b2149 |
PATRICi | fig|1411691.4.peg.92 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59444 Genomic DNA Translation: AAA24170.1 U00096 Genomic DNA Translation: AAC75210.1 AP009048 Genomic DNA Translation: BAE76626.1 X05646 Genomic DNA Translation: CAA29133.1 |
PIRi | D64983 |
RefSeqi | NP_416654.1, NC_000913.3 WP_000255039.1, NZ_SSZK01000011.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260868, 26 interactors 853280, 6 interactors |
ComplexPortali | CPX-4341, Beta-methyl-D-galactoside/galactose ABC transporter complex |
IntActi | P0AAG8, 13 interactors |
STRINGi | 511145.b2149 |
Protein family/group databases
TCDBi | 3.A.1.2.3, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P0AAG8 |
PaxDbi | P0AAG8 |
PRIDEi | P0AAG8 |
Genome annotation databases
EnsemblBacteriai | AAC75210; AAC75210; b2149 BAE76626; BAE76626; BAE76626 |
GeneIDi | 58388968 949036 |
KEGGi | ecj:JW2136 eco:b2149 |
PATRICi | fig|1411691.4.peg.92 |
Organism-specific databases
EchoBASEi | EB0587 |
Phylogenomic databases
eggNOGi | COG1129, Bacteria |
HOGENOMi | CLU_000604_92_3_6 |
InParanoidi | P0AAG8 |
PhylomeDBi | P0AAG8 |
Enzyme and pathway databases
BioCyci | EcoCyc:MGLA-MONOMER MetaCyc:MGLA-MONOMER |
Miscellaneous databases
PROi | PR:P0AAG8 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015862, ABC_transpr_MglA IPR027417, P-loop_NTPase |
PANTHERi | PTHR43790:SF7, PTHR43790:SF7, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits PS51260, MGLA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MGLA_ECOLI | |
Accessioni | P0AAG8Primary (citable) accession number: P0AAG8 Secondary accession number(s): P23199, P76442, Q2MAT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families