UniProtKB - P0AAF3 (ARAG_ECOLI)
Protein
Arabinose import ATP-binding protein AraG
Gene
araG
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable).2 Publications
Catalytic activityi
- EC:7.5.2.12UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 47 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: EcoCyc
- ATP binding Source: UniProtKB-KW
- L-arabinose-importing ATPase activity Source: UniProtKB-UniRule
GO - Biological processi
- L-arabinose transmembrane transport Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Sugar transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:ARAG-MONOMER MetaCyc:ARAG-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.2.2, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Arabinose import ATP-binding protein AraGUniRule annotation (EC:7.5.2.12UniRule annotation) |
Gene namesi | Name:araGUniRule annotation Ordered Locus Names:b1900, JW1888 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation1 Publication
GO - Cellular componenti
- cytosol Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091936 | 1 – 504 | Arabinose import ATP-binding protein AraGAdd BLAST | 504 |
Proteomic databases
PaxDbi | P0AAF3 |
PRIDEi | P0AAF3 |
Expressioni
Inductioni
Induced by arabinose. Transcription is dependent on the transcription factor AraC, the cAMP receptor protein (CRP) and cAMP.1 Publication
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (AraG), two transmembrane proteins (AraH) and a solute-binding protein (AraF).
UniRule annotationBinary interactionsi
P0AAF3
With | #Exp. | IntAct |
---|---|---|
metQ [P28635] | 3 | EBI-559586,EBI-1114713 |
Protein-protein interaction databases
BioGRIDi | 4261851, 4 interactors 850765, 4 interactors |
ComplexPortali | CPX-4314, Arabinose ABC transporter complex |
DIPi | DIP-48055N |
IntActi | P0AAF3, 7 interactors |
STRINGi | 511145.b1900 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 243 | ABC transporter 1UniRule annotationAdd BLAST | 236 | |
Domaini | 256 – 499 | ABC transporter 2UniRule annotationAdd BLAST | 244 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family. [View classification]UniRule annotation
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | COG1129, Bacteria |
HOGENOMi | CLU_000604_92_3_6 |
InParanoidi | P0AAF3 |
PhylomeDBi | P0AAF3 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR017917, ABC_transptr_Ara_ATP-bd_AraG IPR027417, P-loop_NTPase |
PANTHERi | PTHR43790:SF6, PTHR43790:SF6, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits PS51268, ARAG, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AAF3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQSTPYLSF RGIGKTFPGV KALTDISFDC YAGQVHALMG ENGAGKSTLL
60 70 80 90 100
KILSGNYAPT TGSVVINGQE MSFSDTTAAL NAGVAIIYQE LHLVPEMTVA
110 120 130 140 150
ENIYLGQLPH KGGIVNRSLL NYEAGLQLKH LGMDIDPDTP LKYLSIGQWQ
160 170 180 190 200
MVEIAKALAR NAKIIAFDEP TSSLSAREID NLFRVIRELR KEGRVILYVS
210 220 230 240 250
HRMEEIFALS DAITVFKDGR YVKTFTDMQQ VDHDALVQAM VGRDIGDIYG
260 270 280 290 300
WQPRSYGEER LRLDAVKAPG VRTPISLAVR SGEIVGLFGL VGAGRSELMK
310 320 330 340 350
GMFGGTQITA GQVYIDQQPI DIRKPSHAIA AGMMLCPEDR KAEGIIPVHS
360 370 380 390 400
VRDNINISAR RKHVLGGCVI NNGWEENNAD HHIRSLNIKT PGAEQLIMNL
410 420 430 440 450
SGGNQQKAIL GRWLSEEMKV ILLDEPTRGI DVGAKHEIYN VIYALAAQGV
460 470 480 490 500
AVLFASSDLP EVLGVADRIV VMREGEIAGE LLHEQADERQ ALSLAMPKVS
QAVA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06091 Genomic DNA Translation: CAA29477.1 U00096 Genomic DNA Translation: AAC74970.1 AP009048 Genomic DNA Translation: BAA15720.1 |
PIRi | S01074 |
RefSeqi | NP_416413.1, NC_000913.3 WP_001187819.1, NZ_SSZK01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC74970; AAC74970; b1900 BAA15720; BAA15720; BAA15720 |
GeneIDi | 946408 |
KEGGi | ecj:JW1888 eco:b1900 |
PATRICi | fig|1411691.4.peg.350 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06091 Genomic DNA Translation: CAA29477.1 U00096 Genomic DNA Translation: AAC74970.1 AP009048 Genomic DNA Translation: BAA15720.1 |
PIRi | S01074 |
RefSeqi | NP_416413.1, NC_000913.3 WP_001187819.1, NZ_SSZK01000001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261851, 4 interactors 850765, 4 interactors |
ComplexPortali | CPX-4314, Arabinose ABC transporter complex |
DIPi | DIP-48055N |
IntActi | P0AAF3, 7 interactors |
STRINGi | 511145.b1900 |
Protein family/group databases
TCDBi | 3.A.1.2.2, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P0AAF3 |
PRIDEi | P0AAF3 |
Genome annotation databases
EnsemblBacteriai | AAC74970; AAC74970; b1900 BAA15720; BAA15720; BAA15720 |
GeneIDi | 946408 |
KEGGi | ecj:JW1888 eco:b1900 |
PATRICi | fig|1411691.4.peg.350 |
Organism-specific databases
EchoBASEi | EB0056 |
Phylogenomic databases
eggNOGi | COG1129, Bacteria |
HOGENOMi | CLU_000604_92_3_6 |
InParanoidi | P0AAF3 |
PhylomeDBi | P0AAF3 |
Enzyme and pathway databases
BioCyci | EcoCyc:ARAG-MONOMER MetaCyc:ARAG-MONOMER |
Miscellaneous databases
PROi | PR:P0AAF3 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR017917, ABC_transptr_Ara_ATP-bd_AraG IPR027417, P-loop_NTPase |
PANTHERi | PTHR43790:SF6, PTHR43790:SF6, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits PS51268, ARAG, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARAG_ECOLI | |
Accessioni | P0AAF3Primary (citable) accession number: P0AAF3 Secondary accession number(s): P08531 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families