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UniProtKB - P0AAE4 (PROY_ECO57)
Protein
Proline-specific permease ProY
Gene
proY
Organism
Escherichia coli O157:H7
Status
Functioni
Permease that is involved in the transport across the cytoplasmic membrane of proline.
By similarityGO - Biological processi
- amino acid transport Source: UniProtKB-KW
- transmembrane transport Source: InterPro
Keywordsi
Biological process | Amino-acid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-specific permease ProY |
Gene namesi | Name:proY Ordered Locus Names:Z0500, ECs0452 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 84 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 85 – 105 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 106 – 113 | PeriplasmicSequence analysis | 8 | |
Transmembranei | 114 – 134 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 135 – 156 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 197 | PeriplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 198 – 218 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 242 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 243 – 263 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 264 – 277 | PeriplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 331 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 332 – 352 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 355 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 377 – 399 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 400 – 420 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 421 – 424 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 457 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054208 | 1 – 457 | Proline-specific permease ProYAdd BLAST | 457 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1113, Bacteria |
HOGENOMi | CLU_007946_9_3_6 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AAE4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESKNKLKRG LSTRHIRFMA LGSAIGTGLF YGSADAIKMA GPSVLLAYII
60 70 80 90 100
GGIAAYIIMR ALGEMSVHNP AASSFSRYAQ ENLGPLAGYI TGWTYCFEIL
110 120 130 140 150
IVAIADVTAF GIYMGVWFPT VPHWIWVLSV VLIICAVNLM SVKVFGELEF
160 170 180 190 200
WFSFFKVATI IIMIVAGFGI IIWGIGNGGQ PTGIHNLWSN GGFFSNGWLG
210 220 230 240 250
MVMSLQMVMF AYGGIEIIGI TAGEAKDPEK SIPRAINSVP MRILVFYVGT
260 270 280 290 300
LFVIMSIYPW NQVGTAGSPF VLTFQHMGIT FAASILNFVV LTASLSAINS
310 320 330 340 350
DVFGVGRMLH GMAEQGSAPK IFSKTSRRGI PWVTVLVMTT ALLFAVYLNY
360 370 380 390 400
IMPENVFLVI ASLATFATVW VWIMILLSQI AFRRRLPPEE VKALKFKVPG
410 420 430 440 450
GVATTIGGLI FLLFIIGLIG YHPDTRISLY VGFAWIVVLL IGWMFKRRHD
RQLAENQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG54748.1 BA000007 Genomic DNA Translation: BAB33875.1 |
PIRi | D90685 H85535 |
RefSeqi | NP_308479.1, NC_002695.1 WP_001295329.1, NZ_SWKA01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAG54748; AAG54748; Z0500 BAB33875; BAB33875; ECs_0452 |
GeneIDi | 66671299 914554 |
KEGGi | ece:Z0500 ecs:ECs0452 |
PATRICi | fig|386585.9.peg.552 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG54748.1 BA000007 Genomic DNA Translation: BAB33875.1 |
PIRi | D90685 H85535 |
RefSeqi | NP_308479.1, NC_002695.1 WP_001295329.1, NZ_SWKA01000005.1 |
3D structure databases
SMRi | P0AAE4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 386585.gene:10363438 |
Genome annotation databases
EnsemblBacteriai | AAG54748; AAG54748; Z0500 BAB33875; BAB33875; ECs_0452 |
GeneIDi | 66671299 914554 |
KEGGi | ece:Z0500 ecs:ECs0452 |
PATRICi | fig|386585.9.peg.552 |
Phylogenomic databases
eggNOGi | COG1113, Bacteria |
HOGENOMi | CLU_007946_9_3_6 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PROY_ECO57 | |
Accessioni | P0AAE4Primary (citable) accession number: P0AAE4 Secondary accession number(s): P77327 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families