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Protein

D-serine/D-alanine/glycine transporter

Gene

cycA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
D-serine/D-alanine/glycine transporter
Gene namesi
Name:cycA
Ordered Locus Names:Z5819, ECs5186
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 101CytoplasmicSequence analysisAdd BLAST30
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 136PeriplasmicSequence analysisAdd BLAST14
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 161CytoplasmicSequence analysis4
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 210PeriplasmicSequence analysisAdd BLAST28
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 255CytoplasmicSequence analysisAdd BLAST24
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 282PeriplasmicSequence analysis6
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 349CytoplasmicSequence analysisAdd BLAST46
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 412CytoplasmicSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 440PeriplasmicSequence analysis7
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 470CytoplasmicSequence analysis9

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542001 – 470D-serine/D-alanine/glycine transporterAdd BLAST470

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5819

Structurei

3D structure databases

ProteinModelPortaliP0AAE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85 Bacteria
COG1113 LUCA
HOGENOMiHOG000261849
KOiK11737
OMAiINFITRY

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P0AAE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDQVKVVAD DQAPAEQSLR RNLTNRHIQL IAIGGAIGTG LFMGSGKTIS
60 70 80 90 100
LAGPSIIFVY MIIGFMLFFV MRAMGELLLS NLEYKSFSDF ASDLLGPWAG
110 120 130 140 150
YFTGWTYWFC WVVTGMADVV AITAYAQFWF PDLSDWVASL AVIVLLLTLN
160 170 180 190 200
LATVKMFGEM EFWFAMIKIV AIVSLIVVGL VMVAMHFQSP TGVEASFAHL
210 220 230 240 250
WNDGGWFPKG LSGFFAGFQI AVFAFVGIEL VGTTAAETKD PEKSLPRAIN
260 270 280 290 300
SIPIRIIMFY VFALIVIMSV TPWSSVVPEK SPFVELFVLV GLPAAASVIN
310 320 330 340 350
FVVLTSAASS ANSGVFSTSR MLFGLAQEGV APKAFAKLSK RAVPAKGLTF
360 370 380 390 400
SCICLLGGVV MLYVNPSVIG AFTMITTVSA ILFMFVWTII LCSYLVYRKQ
410 420 430 440 450
RPHLHEKSIY KMPLGKLMCW VCMAFFVFVV VLLTLEDDTR QALLVTPLWF
460 470
IALGLGWLFI GKKRAAELRK
Length:470
Mass (Da):51,660
Last modified:October 11, 2005 - v1
Checksum:iF9279E48D838EAF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59406.1
BA000007 Genomic DNA Translation: BAB38609.1
PIRiB86118
B91277
RefSeqiNP_313213.1, NC_002695.1
WP_000228346.1, NZ_MWVM01000025.1

Genome annotation databases

EnsemblBacteriaiAAG59406; AAG59406; Z5819
BAB38609; BAB38609; BAB38609
GeneIDi913962
KEGGiece:Z5819
ecs:ECs5186
PATRICifig|386585.9.peg.5421

Similar proteinsi

Entry informationi

Entry nameiCYCA_ECO57
AccessioniPrimary (citable) accession number: P0AAE1
Secondary accession number(s): P39312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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