UniProtKB - P0AAD6 (SDAC_ECOLI)
Serine transporter SdaC
sdaC
Functioni
Mediates the import of L-serine into the cell (PubMed:8026499, PubMed:3129404).
Is energized by proton cotransport (PubMed:3129404).
Promotes amino acid homeostasis during adaptation to glucose limitation (PubMed:31680488).
May also be involved in ampicillin sensitivity (Probable).
1 Publication3 Publications(Microbial infection) Involved in phage C1 and phage C6 infection (PubMed:8752353, PubMed:12558182).
Participates in phage DNA transport pathways in cooperation with different outer membrane receptors, including FhuA and BtuB (PubMed:12558182).
Is probably required in the second stage of phage adsorption, the DNA injection process. Participates in the formation or opening of diffusion channels through the outer membrane after phage adsorption (PubMed:12558182).
2 Publications(Microbial infection) May function as an inner membrane receptor of colicin V (ColV), a peptide antibiotic secreted by some members of the Enterobacteriaceae to kill closely related bacterial cells.
1 PublicationCatalytic activityi
- This reaction proceeds in the backward1 Publication direction.
Activity regulationi
Kineticsi
- KM=50 µM for L-serine1 Publication
- Vmax=23 nmol/min/mg enzyme1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: InterPro
- symporter activity Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Symport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:SDAC-MONOMER |
Protein family/group databases
TCDBi | 2.A.42.2.1, the hydroxy/aromatic amino acid permease (haaap) family |
Names & Taxonomyi
Protein namesi | Recommended name: Serine transporter SdaC1 PublicationAlternative name(s): H(+)/L-serine symporterCurated L-serine transport system1 Publication |
Gene namesi | Name:sdaC1 Publication Synonyms:dcrA1 Publication Ordered Locus Names:b2796, JW2767 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: EcoliWiki
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | CytoplasmicCuratedAdd BLAST | 22 | |
Transmembranei | 23 – 43 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 44 – 46 | PeriplasmicCurated | 3 | |
Transmembranei | 47 – 67 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 68 – 99 | CytoplasmicCuratedAdd BLAST | 32 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 140 | PeriplasmicCuratedAdd BLAST | 20 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 163 | CytoplasmicCurated | 2 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 201 | PeriplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 223 – 249 | CytoplasmicCuratedAdd BLAST | 27 | |
Transmembranei | 250 – 270 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 271 – 297 | PeriplasmicCuratedAdd BLAST | 27 | |
Transmembranei | 298 – 318 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 319 – 347 | CytoplasmicCuratedAdd BLAST | 29 | |
Transmembranei | 348 – 368 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 369 | PeriplasmicCurated | 1 | |
Transmembranei | 370 – 390 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 391 – 406 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 429 | Periplasmic1 Publication | 2 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093808 | 1 – 429 | Serine transporter SdaCAdd BLAST | 429 |
Proteomic databases
jPOSTi | P0AAD6 |
PaxDbi | P0AAD6 |
PRIDEi | P0AAD6 |
Expressioni
Inductioni
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261307, 23 interactors |
STRINGi | 511145.b2796 |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0814, Bacteria |
HOGENOMi | CLU_052043_1_1_6 |
PhylomeDBi | P0AAD6 |
Family and domain databases
InterProi | View protein in InterPro IPR004694, Hydroxy_aa_transpt |
TIGRFAMsi | TIGR00814, stp, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
METTQTSTIA SKDSRSAWRK TDTMWMLGLY GTAIGAGVLF LPINAGVGGM
60 70 80 90 100
IPLIIMAILA FPMTFFAHRG LTRFVLSGKN PGEDITEVVE EHFGIGAGKL
110 120 130 140 150
ITLLYFFAIY PILLVYSVAI TNTVESFMSH QLGMTPPPRA ILSLILIVGM
160 170 180 190 200
MTIVRFGEQM IVKAMSILVF PFVGVLMLLA LYLIPQWNGA ALETLSLDTA
210 220 230 240 250
SATGNGLWMT LWLAIPVMVF SFNHSPIISS FAVAKREEYG DMAEQKCSKI
260 270 280 290 300
LAFAHIMMVL TVMFFVFSCV LSLTPADLAA AKEQNISILS YLANHFNAPV
310 320 330 340 350
IAWMAPIIAI IAITKSFLGH YLGAREGFNG MVIKSLRGKG KSIEINKLNR
360 370 380 390 400
ITALFMLVTT WIVATLNPSI LGMIETLGGP IIAMILFLMP MYAIQKVPAM
410 420
RKYSGHISNV FVVVMGLIAI SAIFYSLFS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U01233 Genomic DNA Translation: AAA50169.1 U29581 Genomic DNA Translation: AAB40446.1 U00096 Genomic DNA Translation: AAC75838.1 AP009048 Genomic DNA Translation: BAE76868.1 |
PIRi | S45633 |
RefSeqi | NP_417276.1, NC_000913.3 WP_000450476.1, NZ_STEB01000030.1 |
Genome annotation databases
EnsemblBacteriai | AAC75838; AAC75838; b2796 BAE76868; BAE76868; BAE76868 |
GeneIDi | 66673337 947264 |
KEGGi | ecj:JW2767 eco:b2796 |
PATRICi | fig|1411691.4.peg.3937 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U01233 Genomic DNA Translation: AAA50169.1 U29581 Genomic DNA Translation: AAB40446.1 U00096 Genomic DNA Translation: AAC75838.1 AP009048 Genomic DNA Translation: BAE76868.1 |
PIRi | S45633 |
RefSeqi | NP_417276.1, NC_000913.3 WP_000450476.1, NZ_STEB01000030.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261307, 23 interactors |
STRINGi | 511145.b2796 |
Protein family/group databases
TCDBi | 2.A.42.2.1, the hydroxy/aromatic amino acid permease (haaap) family |
Proteomic databases
jPOSTi | P0AAD6 |
PaxDbi | P0AAD6 |
PRIDEi | P0AAD6 |
Genome annotation databases
EnsemblBacteriai | AAC75838; AAC75838; b2796 BAE76868; BAE76868; BAE76868 |
GeneIDi | 66673337 947264 |
KEGGi | ecj:JW2767 eco:b2796 |
PATRICi | fig|1411691.4.peg.3937 |
Organism-specific databases
EchoBASEi | EB2063 |
Phylogenomic databases
eggNOGi | COG0814, Bacteria |
HOGENOMi | CLU_052043_1_1_6 |
PhylomeDBi | P0AAD6 |
Enzyme and pathway databases
BioCyci | EcoCyc:SDAC-MONOMER |
Miscellaneous databases
PROi | PR:P0AAD6 |
Family and domain databases
InterProi | View protein in InterPro IPR004694, Hydroxy_aa_transpt |
TIGRFAMsi | TIGR00814, stp, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SDAC_ECOLI | |
Accessioni | P0AAD6Primary (citable) accession number: P0AAD6 Secondary accession number(s): P36559, Q2MA38 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families