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Entry version 107 (23 Feb 2022)
Sequence version 1 (11 Oct 2005)
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Protein

Serine transporter SdaC

Gene

sdaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the import of L-serine into the cell (PubMed:8026499, PubMed:3129404).

Is energized by proton cotransport (PubMed:3129404).

Promotes amino acid homeostasis during adaptation to glucose limitation (PubMed:31680488).

May also be involved in ampicillin sensitivity (Probable).

1 Publication3 Publications

(Microbial infection) Involved in phage C1 and phage C6 infection (PubMed:8752353, PubMed:12558182).

Participates in phage DNA transport pathways in cooperation with different outer membrane receptors, including FhuA and BtuB (PubMed:12558182).

Is probably required in the second stage of phage adsorption, the DNA injection process. Participates in the formation or opening of diffusion channels through the outer membrane after phage adsorption (PubMed:12558182).

2 Publications

(Microbial infection) May function as an inner membrane receptor of colicin V (ColV), a peptide antibiotic secreted by some members of the Enterobacteriaceae to kill closely related bacterial cells.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Serine transport is strongly inhibited by KCN, an inhibitor of the respiratory chain, or by CCCP.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=50 µM for L-serine1 Publication
  1. Vmax=23 nmol/min/mg enzyme1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Symport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:SDAC-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.42.2.1, the hydroxy/aromatic amino acid permease (haaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine transporter SdaC1 Publication
Alternative name(s):
H(+)/L-serine symporterCurated
L-serine transport system1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sdaC1 Publication
Synonyms:dcrA1 Publication
Ordered Locus Names:b2796, JW2767
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22CytoplasmicCuratedAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 46PeriplasmicCurated3
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 99CytoplasmicCuratedAdd BLAST32
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 140PeriplasmicCuratedAdd BLAST20
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 163CytoplasmicCurated2
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 201PeriplasmicCuratedAdd BLAST17
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 249CytoplasmicCuratedAdd BLAST27
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 297PeriplasmicCuratedAdd BLAST27
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 347CytoplasmicCuratedAdd BLAST29
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369PeriplasmicCurated1
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 406CytoplasmicCuratedAdd BLAST16
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 429Periplasmic1 Publication2

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disruption of the gene leads to phage C1 adsorption defect. Mutation does not impair vitamin B12 utilization. Inactivation also leads to increased ampicillin resistance (PubMed:8752353). Mutant is resistant to phage C6 (PubMed:12558182). Mutation also confers resistance to ColV (PubMed:15743941). Deletion mutant lyses upon glucose depletion in the absence of exogenous serine (PubMed:31680488).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000938081 – 429Serine transporter SdaCAdd BLAST429

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0AAD6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AAD6

PRoteomics IDEntifications database

More...
PRIDEi
P0AAD6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By leucine and by growth in rich medium (PubMed:3129404, PubMed:19429622). Repressed by LeuO. Part of the sdaCB operon (PubMed:19429622).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261307, 23 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2796

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0814, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_052043_1_1_6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AAD6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004694, Hydroxy_aa_transpt

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00814, stp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AAD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METTQTSTIA SKDSRSAWRK TDTMWMLGLY GTAIGAGVLF LPINAGVGGM
60 70 80 90 100
IPLIIMAILA FPMTFFAHRG LTRFVLSGKN PGEDITEVVE EHFGIGAGKL
110 120 130 140 150
ITLLYFFAIY PILLVYSVAI TNTVESFMSH QLGMTPPPRA ILSLILIVGM
160 170 180 190 200
MTIVRFGEQM IVKAMSILVF PFVGVLMLLA LYLIPQWNGA ALETLSLDTA
210 220 230 240 250
SATGNGLWMT LWLAIPVMVF SFNHSPIISS FAVAKREEYG DMAEQKCSKI
260 270 280 290 300
LAFAHIMMVL TVMFFVFSCV LSLTPADLAA AKEQNISILS YLANHFNAPV
310 320 330 340 350
IAWMAPIIAI IAITKSFLGH YLGAREGFNG MVIKSLRGKG KSIEINKLNR
360 370 380 390 400
ITALFMLVTT WIVATLNPSI LGMIETLGGP IIAMILFLMP MYAIQKVPAM
410 420
RKYSGHISNV FVVVMGLIAI SAIFYSLFS
Length:429
Mass (Da):46,906
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF97AB93F84A38FE6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U01233 Genomic DNA Translation: AAA50169.1
U29581 Genomic DNA Translation: AAB40446.1
U00096 Genomic DNA Translation: AAC75838.1
AP009048 Genomic DNA Translation: BAE76868.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45633

NCBI Reference Sequences

More...
RefSeqi
NP_417276.1, NC_000913.3
WP_000450476.1, NZ_STEB01000030.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75838; AAC75838; b2796
BAE76868; BAE76868; BAE76868

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66673337
947264

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2767
eco:b2796

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3937

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01233 Genomic DNA Translation: AAA50169.1
U29581 Genomic DNA Translation: AAB40446.1
U00096 Genomic DNA Translation: AAC75838.1
AP009048 Genomic DNA Translation: BAE76868.1
PIRiS45633
RefSeqiNP_417276.1, NC_000913.3
WP_000450476.1, NZ_STEB01000030.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261307, 23 interactors
STRINGi511145.b2796

Protein family/group databases

TCDBi2.A.42.2.1, the hydroxy/aromatic amino acid permease (haaap) family

Proteomic databases

jPOSTiP0AAD6
PaxDbiP0AAD6
PRIDEiP0AAD6

Genome annotation databases

EnsemblBacteriaiAAC75838; AAC75838; b2796
BAE76868; BAE76868; BAE76868
GeneIDi66673337
947264
KEGGiecj:JW2767
eco:b2796
PATRICifig|1411691.4.peg.3937

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2063

Phylogenomic databases

eggNOGiCOG0814, Bacteria
HOGENOMiCLU_052043_1_1_6
PhylomeDBiP0AAD6

Enzyme and pathway databases

BioCyciEcoCyc:SDAC-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AAD6

Family and domain databases

InterProiView protein in InterPro
IPR004694, Hydroxy_aa_transpt
TIGRFAMsiTIGR00814, stp, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDAC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AAD6
Secondary accession number(s): P36559, Q2MA38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 23, 2022
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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