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Entry version 105 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Tryptophan-specific transport protein

Gene

mtr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transporting tryptophan across the cytoplasmic membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:MTR-MONOMER
MetaCyc:MTR-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.42.1.2, the hydroxy/aromatic amino acid permease (haaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tryptophan-specific transport protein
Alternative name(s):
Tryptophan permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mtr
Ordered Locus Names:b3161, JW3130
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicCurated10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 34HelicalCuratedAdd BLAST24
Topological domaini35 – 38PeriplasmicCurated4
Transmembranei39 – 61HelicalCuratedAdd BLAST23
Topological domaini62 – 86CytoplasmicCuratedAdd BLAST25
Transmembranei87 – 109HelicalCuratedAdd BLAST23
Topological domaini110 – 122PeriplasmicCuratedAdd BLAST13
Transmembranei123 – 145HelicalCuratedAdd BLAST23
Topological domaini146 – 151CytoplasmicCurated6
Transmembranei152 – 174HelicalCuratedAdd BLAST23
Topological domaini175 – 188PeriplasmicCuratedAdd BLAST14
Transmembranei189 – 210HelicalCuratedAdd BLAST22
Topological domaini211 – 227CytoplasmicCuratedAdd BLAST17
Transmembranei228 – 251HelicalCuratedAdd BLAST24
Topological domaini252 – 281PeriplasmicCuratedAdd BLAST30
Transmembranei282 – 303HelicalCuratedAdd BLAST22
Topological domaini304 – 321CytoplasmicCuratedAdd BLAST18
Transmembranei322 – 343HelicalCuratedAdd BLAST22
Transmembranei344 – 365HelicalCuratedAdd BLAST22
Topological domaini366 – 386CytoplasmicCuratedAdd BLAST21
Transmembranei387 – 409HelicalCuratedAdd BLAST23
Topological domaini410 – 414PeriplasmicCurated5

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000937971 – 414Tryptophan-specific transport proteinAdd BLAST414

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0AAD2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AAD2

PRoteomics IDEntifications database

More...
PRIDEi
P0AAD2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By phenylalanine under the control of regulatory protein TyrR.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259278, 178 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3161

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0814, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038102_2_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AAD2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AAD2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018227, Amino_acid_transport_2
IPR013061, Trp/try_permease_CS
IPR013059, Trp_tyr_transpt

The PANTHER Classification System

More...
PANTHERi
PTHR46997, PTHR46997, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03222, Trp_Tyr_perm, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00166, AROAAPRMEASE

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00837, araaP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00594, AROMATIC_AA_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AAD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLTTTQTS PSLLGGVVII GGTIIGAGMF SLPVVMSGAW FFWSMAALIF
60 70 80 90 100
TWFCMLHSGL MILEANLNYR IGSSFDTITK DLLGKGWNVV NGISIAFVLY
110 120 130 140 150
ILTYAYISAS GSILHHTFAE MSLNVPARAA GFGFALLVAF VVWLSTKAVS
160 170 180 190 200
RMTAIVLGAK VITFFLTFGS LLGHVQPATL FNVAESNASY APYLLMTLPF
210 220 230 240 250
CLASFGYHGN VPSLMKYYGK DPKTIVKCLV YGTLMALALY TIWLLATMGN
260 270 280 290 300
IPRPEFIGIA EKGGNIDVLV QALSGVLNSR SLDLLLVVFS NFAVASSFLG
310 320 330 340 350
VTLGLFDYLA DLFGFDDSAV GRLKTALLTF APPVVGGLLF PNGFLYAIGY
360 370 380 390 400
AGLAATIWAA IVPALLARAS RKRFGSPKFR VWGGKPMIAL ILVFGVGNAL
410
VHILSSFNLL PVYQ
Length:414
Mass (Da):44,333
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87BF42540862FDD0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M59862 Genomic DNA Translation: AAA24182.1
M58338 Genomic DNA Translation: AAA24183.1
U18997 Genomic DNA Translation: AAA57964.1
U00096 Genomic DNA Translation: AAC76195.1
AP009048 Genomic DNA Translation: BAE77207.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A39187

NCBI Reference Sequences

More...
RefSeqi
NP_417630.1, NC_000913.3
WP_000224351.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76195; AAC76195; b3161
BAE77207; BAE77207; BAE77207

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3130
eco:b3161

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3569

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59862 Genomic DNA Translation: AAA24182.1
M58338 Genomic DNA Translation: AAA24183.1
U18997 Genomic DNA Translation: AAA57964.1
U00096 Genomic DNA Translation: AAC76195.1
AP009048 Genomic DNA Translation: BAE77207.1
PIRiA39187
RefSeqiNP_417630.1, NC_000913.3
WP_000224351.1, NZ_LN832404.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4259278, 178 interactors
STRINGi511145.b3161

Protein family/group databases

TCDBi2.A.42.1.2, the hydroxy/aromatic amino acid permease (haaap) family

Proteomic databases

jPOSTiP0AAD2
PaxDbiP0AAD2
PRIDEiP0AAD2

Genome annotation databases

EnsemblBacteriaiAAC76195; AAC76195; b3161
BAE77207; BAE77207; BAE77207
GeneIDi947675
KEGGiecj:JW3130
eco:b3161
PATRICifig|1411691.4.peg.3569

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0612

Phylogenomic databases

eggNOGiCOG0814, Bacteria
HOGENOMiCLU_038102_2_1_6
InParanoidiP0AAD2
PhylomeDBiP0AAD2

Enzyme and pathway databases

BioCyciEcoCyc:MTR-MONOMER
MetaCyc:MTR-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AAD2

Family and domain databases

InterProiView protein in InterPro
IPR018227, Amino_acid_transport_2
IPR013061, Trp/try_permease_CS
IPR013059, Trp_tyr_transpt
PANTHERiPTHR46997, PTHR46997, 1 hit
PfamiView protein in Pfam
PF03222, Trp_Tyr_perm, 1 hit
PRINTSiPR00166, AROAAPRMEASE
TIGRFAMsiTIGR00837, araaP, 1 hit
PROSITEiView protein in PROSITE
PS00594, AROMATIC_AA_PERMEASE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTR_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AAD2
Secondary accession number(s): P22306, Q2M949
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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