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UniProtKB - P0AAD2 (MTR_ECOLI)
Protein
Tryptophan-specific transport protein
Gene
mtr
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in transporting tryptophan across the cytoplasmic membrane.
GO - Molecular functioni
- active transmembrane transporter activity Source: EcoCyc
- high-affinity tryptophan transmembrane transporter activity Source: EcoCyc
- symporter activity Source: EcoCyc
GO - Biological processi
- amino acid transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:MTR-MONOMER |
Protein family/group databases
TCDBi | 2.A.42.1.2, the hydroxy/aromatic amino acid permease (haaap) family |
Names & Taxonomyi
Protein namesi | Recommended name: Tryptophan-specific transport proteinAlternative name(s): Tryptophan permease |
Gene namesi | Name:mtr Ordered Locus Names:b3161, JW3130 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoliWiki
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicCurated | 10 | |
Transmembranei | 11 – 34 | HelicalCuratedAdd BLAST | 24 | |
Topological domaini | 35 – 38 | PeriplasmicCurated | 4 | |
Transmembranei | 39 – 61 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 62 – 86 | CytoplasmicCuratedAdd BLAST | 25 | |
Transmembranei | 87 – 109 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 110 – 122 | PeriplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 123 – 145 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 146 – 151 | CytoplasmicCurated | 6 | |
Transmembranei | 152 – 174 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 175 – 188 | PeriplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 189 – 210 | HelicalCuratedAdd BLAST | 22 | |
Topological domaini | 211 – 227 | CytoplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 228 – 251 | HelicalCuratedAdd BLAST | 24 | |
Topological domaini | 252 – 281 | PeriplasmicCuratedAdd BLAST | 30 | |
Transmembranei | 282 – 303 | HelicalCuratedAdd BLAST | 22 | |
Topological domaini | 304 – 321 | CytoplasmicCuratedAdd BLAST | 18 | |
Transmembranei | 322 – 343 | HelicalCuratedAdd BLAST | 22 | |
Transmembranei | 344 – 365 | HelicalCuratedAdd BLAST | 22 | |
Topological domaini | 366 – 386 | CytoplasmicCuratedAdd BLAST | 21 | |
Transmembranei | 387 – 409 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 410 – 414 | PeriplasmicCurated | 5 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093797 | 1 – 414 | Tryptophan-specific transport proteinAdd BLAST | 414 |
Proteomic databases
jPOSTi | P0AAD2 |
PaxDbi | P0AAD2 |
PRIDEi | P0AAD2 |
Expressioni
Inductioni
By phenylalanine under the control of regulatory protein TyrR.
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259278, 178 interactors |
STRINGi | 511145.b3161 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0814, Bacteria |
HOGENOMi | CLU_038102_2_1_6 |
InParanoidi | P0AAD2 |
PhylomeDBi | P0AAD2 |
Family and domain databases
InterProi | View protein in InterPro IPR018227, Amino_acid_transport_2 IPR013061, Trp/try_permease_CS IPR013059, Trp_tyr_transpt |
PANTHERi | PTHR46997, PTHR46997, 1 hit |
Pfami | View protein in Pfam PF03222, Trp_Tyr_perm, 1 hit |
PRINTSi | PR00166, AROAAPRMEASE |
TIGRFAMsi | TIGR00837, araaP, 1 hit |
PROSITEi | View protein in PROSITE PS00594, AROMATIC_AA_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AAD2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLTTTQTS PSLLGGVVII GGTIIGAGMF SLPVVMSGAW FFWSMAALIF
60 70 80 90 100
TWFCMLHSGL MILEANLNYR IGSSFDTITK DLLGKGWNVV NGISIAFVLY
110 120 130 140 150
ILTYAYISAS GSILHHTFAE MSLNVPARAA GFGFALLVAF VVWLSTKAVS
160 170 180 190 200
RMTAIVLGAK VITFFLTFGS LLGHVQPATL FNVAESNASY APYLLMTLPF
210 220 230 240 250
CLASFGYHGN VPSLMKYYGK DPKTIVKCLV YGTLMALALY TIWLLATMGN
260 270 280 290 300
IPRPEFIGIA EKGGNIDVLV QALSGVLNSR SLDLLLVVFS NFAVASSFLG
310 320 330 340 350
VTLGLFDYLA DLFGFDDSAV GRLKTALLTF APPVVGGLLF PNGFLYAIGY
360 370 380 390 400
AGLAATIWAA IVPALLARAS RKRFGSPKFR VWGGKPMIAL ILVFGVGNAL
410
VHILSSFNLL PVYQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59862 Genomic DNA Translation: AAA24182.1 M58338 Genomic DNA Translation: AAA24183.1 U18997 Genomic DNA Translation: AAA57964.1 U00096 Genomic DNA Translation: AAC76195.1 AP009048 Genomic DNA Translation: BAE77207.1 |
PIRi | A39187 |
RefSeqi | NP_417630.1, NC_000913.3 WP_000224351.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76195; AAC76195; b3161 BAE77207; BAE77207; BAE77207 |
GeneIDi | 947675 |
KEGGi | ecj:JW3130 eco:b3161 |
PATRICi | fig|1411691.4.peg.3569 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59862 Genomic DNA Translation: AAA24182.1 M58338 Genomic DNA Translation: AAA24183.1 U18997 Genomic DNA Translation: AAA57964.1 U00096 Genomic DNA Translation: AAC76195.1 AP009048 Genomic DNA Translation: BAE77207.1 |
PIRi | A39187 |
RefSeqi | NP_417630.1, NC_000913.3 WP_000224351.1, NZ_LN832404.1 |
3D structure databases
SMRi | P0AAD2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259278, 178 interactors |
STRINGi | 511145.b3161 |
Protein family/group databases
TCDBi | 2.A.42.1.2, the hydroxy/aromatic amino acid permease (haaap) family |
Proteomic databases
jPOSTi | P0AAD2 |
PaxDbi | P0AAD2 |
PRIDEi | P0AAD2 |
Genome annotation databases
EnsemblBacteriai | AAC76195; AAC76195; b3161 BAE77207; BAE77207; BAE77207 |
GeneIDi | 947675 |
KEGGi | ecj:JW3130 eco:b3161 |
PATRICi | fig|1411691.4.peg.3569 |
Organism-specific databases
EchoBASEi | EB0612 |
Phylogenomic databases
eggNOGi | COG0814, Bacteria |
HOGENOMi | CLU_038102_2_1_6 |
InParanoidi | P0AAD2 |
PhylomeDBi | P0AAD2 |
Enzyme and pathway databases
BioCyci | EcoCyc:MTR-MONOMER |
Miscellaneous databases
PROi | PR:P0AAD2 |
Family and domain databases
InterProi | View protein in InterPro IPR018227, Amino_acid_transport_2 IPR013061, Trp/try_permease_CS IPR013059, Trp_tyr_transpt |
PANTHERi | PTHR46997, PTHR46997, 1 hit |
Pfami | View protein in Pfam PF03222, Trp_Tyr_perm, 1 hit |
PRINTSi | PR00166, AROAAPRMEASE |
TIGRFAMsi | TIGR00837, araaP, 1 hit |
PROSITEi | View protein in PROSITE PS00594, AROMATIC_AA_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTR_ECOLI | |
Accessioni | P0AAD2Primary (citable) accession number: P0AAD2 Secondary accession number(s): P22306, Q2M949 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families