UniProtKB - P0AAC0 (USPE_ECOLI)
Protein
Universal stress protein E
Gene
uspE
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for resistance to DNA-damaging agents.1 Publication
GO - Biological processi
- bacterial-type flagellum-dependent cell motility Source: EcoCyc
- cellular response to hydrogen peroxide Source: EcoCyc
- cellular response to UV Source: EcoCyc
- single-species biofilm formation Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:EG11246-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Universal stress protein E |
Gene namesi | Name:uspE Synonyms:ydaA Ordered Locus Names:b1333, JW1327 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000147417 | 2 – 316 | Universal stress protein EAdd BLAST | 315 |
Proteomic databases
jPOSTi | P0AAC0 |
PaxDbi | P0AAC0 |
PRIDEi | P0AAC0 |
2D gel databases
SWISS-2DPAGEi | P0AAC0 |
Expressioni
Inductioni
During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260143, 13 interactors |
DIPi | DIP-48118N |
IntActi | P0AAC0, 3 interactors |
MINTi | P0AAC0 |
STRINGi | 511145.b1333 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0AAC0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal stress protein A family.Curated
Phylogenomic databases
eggNOGi | COG0589, Bacteria |
HOGENOMi | CLU_049301_1_2_6 |
InParanoidi | P0AAC0 |
PhylomeDBi | P0AAC0 |
Family and domain databases
DisProti | DP00991 |
InterProi | View protein in InterPro IPR006016, UspA |
Pfami | View protein in Pfam PF00582, Usp, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AAC0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMYQNMLVV IDPNQDDQPA LRRAVYLHQR IGGKIKAFLP IYDFSYEMTT
60 70 80 90 100
LLSPDERTAM RQGVISQRTA WIHEQAKYYL NAGVPIEIKV VWHNRPFEAI
110 120 130 140 150
IQEVISGGHD LVLKMAHQHD RLEAVIFTPT DWHLLRKCPS PVWMVKDQPW
160 170 180 190 200
PEGGKALVAV NLASEEPYHN ALNEKLVKET IELAEQVNHT EVHLVGAYPV
210 220 230 240 250
TPINIAIELP EFDPSVYNDA IRGQHLLAMK ALRQKFGINE NMTHVEKGLP
260 270 280 290 300
EEVIPDLAEH LQAGIVVLGT VGRTGISAAF LGNTAEQVID HLRCDLLVIK
310
PDQYQTPVEL DDEEDD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | Missing in AAA87982 (PubMed:6292868).Curated | 1 | |
Sequence conflicti | 59 – 73 | AMRQG…TAWIH → RYASGRHQPAYSLDP (PubMed:6292868).CuratedAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74415.1 AP009048 Genomic DNA Translation: BAA14926.1 J01608 Genomic DNA Translation: AAA87982.1 |
PIRi | H64882, QQECX |
RefSeqi | NP_415849.1, NC_000913.3 WP_001262123.1, NZ_STEB01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAC74415; AAC74415; b1333 BAA14926; BAA14926; BAA14926 |
GeneIDi | 58463851 945904 |
KEGGi | ecj:JW1327 eco:b1333 |
PATRICi | fig|1411691.4.peg.944 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74415.1 AP009048 Genomic DNA Translation: BAA14926.1 J01608 Genomic DNA Translation: AAA87982.1 |
PIRi | H64882, QQECX |
RefSeqi | NP_415849.1, NC_000913.3 WP_001262123.1, NZ_STEB01000005.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5CB0 | X-ray | 3.21 | A/B | 1-316 | [»] | |
SMRi | P0AAC0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260143, 13 interactors |
DIPi | DIP-48118N |
IntActi | P0AAC0, 3 interactors |
MINTi | P0AAC0 |
STRINGi | 511145.b1333 |
2D gel databases
SWISS-2DPAGEi | P0AAC0 |
Proteomic databases
jPOSTi | P0AAC0 |
PaxDbi | P0AAC0 |
PRIDEi | P0AAC0 |
Genome annotation databases
EnsemblBacteriai | AAC74415; AAC74415; b1333 BAA14926; BAA14926; BAA14926 |
GeneIDi | 58463851 945904 |
KEGGi | ecj:JW1327 eco:b1333 |
PATRICi | fig|1411691.4.peg.944 |
Organism-specific databases
EchoBASEi | EB1227 |
Phylogenomic databases
eggNOGi | COG0589, Bacteria |
HOGENOMi | CLU_049301_1_2_6 |
InParanoidi | P0AAC0 |
PhylomeDBi | P0AAC0 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11246-MONOMER |
Miscellaneous databases
PROi | PR:P0AAC0 |
Family and domain databases
DisProti | DP00991 |
InterProi | View protein in InterPro IPR006016, UspA |
Pfami | View protein in Pfam PF00582, Usp, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | USPE_ECOLI | |
Accessioni | P0AAC0Primary (citable) accession number: P0AAC0 Secondary accession number(s): P03807, P77421 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 113 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families