UniProtKB - P0AAB6 (GALF_ECOLI)
Protein
UTP--glucose-1-phosphate uridylyltransferase
Gene
galF
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:2.7.7.9
: nucleotide-sugar metabolism Pathwayi
This protein is involved in the pathway nucleotide-sugar metabolism, which is part of Carbohydrate metabolism.View all proteins of this organism that are known to be involved in the pathway nucleotide-sugar metabolism and in Carbohydrate metabolism.
Pathwayi: lipopolysaccharide biosynthesis
This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.
GO - Molecular functioni
- enzyme regulator activity Source: InterPro
- UTP:glucose-1-phosphate uridylyltransferase activity Source: EcoCyc
GO - Biological processi
- lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
- UDP-glucose metabolic process Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipopolysaccharide biosynthesis |
Enzyme and pathway databases
BioCyci | EcoCyc:G7093-MONOMER |
SABIO-RKi | P0AAB6 |
UniPathwayi | UPA00030 UPA00215 |
Names & Taxonomyi
Protein namesi | Recommended name: UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)Alternative name(s): Alpha-D-glucosyl-1-phosphate uridylyltransferase UDP-glucose pyrophosphorylase Short name: UDPGP Uridine diphosphoglucose pyrophosphorylase |
Gene namesi | Name:galF Synonyms:wcaN Ordered Locus Names:b2042, JW2027 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201349 | 1 – 297 | UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST | 297 |
Proteomic databases
jPOSTi | P0AAB6 |
PaxDbi | P0AAB6 |
PRIDEi | P0AAB6 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259678, 180 interactors |
DIPi | DIP-35871N |
IntActi | P0AAB6, 17 interactors |
STRINGi | 511145.b2042 |
Family & Domainsi
Sequence similaritiesi
Belongs to the UDPGP type 2 family.Curated
Phylogenomic databases
eggNOGi | COG1210, Bacteria |
HOGENOMi | CLU_029499_1_1_6 |
InParanoidi | P0AAB6 |
PhylomeDBi | P0AAB6 |
Family and domain databases
CDDi | cd02541, UGPase_prokaryotic, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR005774, GalF IPR005771, GalU_uridylyltTrfase_bac/arc IPR005835, NTP_transferase_dom IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR43197, PTHR43197, 1 hit |
Pfami | View protein in Pfam PF00483, NTP_transferase, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
TIGRFAMsi | TIGR01105, galF, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AAB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK
60 70 80 90 100
EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM
110 120 130 140 150
NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM
160 170 180 190 200
IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD
210 220 230 240 250
QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS
260 270 280 290
VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38473 Genomic DNA Translation: AAC77853.1 U00096 Genomic DNA Translation: AAC75103.1 AP009048 Genomic DNA Translation: BAA15896.1 |
PIRi | A64970 |
RefSeqi | NP_416546.1, NC_000913.3 WP_000183060.1, NZ_STEB01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC75103; AAC75103; b2042 BAA15896; BAA15896; BAA15896 |
GeneIDi | 58390438 946560 |
KEGGi | ecj:JW2027 eco:b2042 |
PATRICi | fig|511145.12.peg.2119 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38473 Genomic DNA Translation: AAC77853.1 U00096 Genomic DNA Translation: AAC75103.1 AP009048 Genomic DNA Translation: BAA15896.1 |
PIRi | A64970 |
RefSeqi | NP_416546.1, NC_000913.3 WP_000183060.1, NZ_STEB01000002.1 |
3D structure databases
SMRi | P0AAB6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259678, 180 interactors |
DIPi | DIP-35871N |
IntActi | P0AAB6, 17 interactors |
STRINGi | 511145.b2042 |
Proteomic databases
jPOSTi | P0AAB6 |
PaxDbi | P0AAB6 |
PRIDEi | P0AAB6 |
Genome annotation databases
EnsemblBacteriai | AAC75103; AAC75103; b2042 BAA15896; BAA15896; BAA15896 |
GeneIDi | 58390438 946560 |
KEGGi | ecj:JW2027 eco:b2042 |
PATRICi | fig|511145.12.peg.2119 |
Organism-specific databases
EchoBASEi | EB3348 |
Phylogenomic databases
eggNOGi | COG1210, Bacteria |
HOGENOMi | CLU_029499_1_1_6 |
InParanoidi | P0AAB6 |
PhylomeDBi | P0AAB6 |
Enzyme and pathway databases
UniPathwayi | UPA00030 UPA00215 |
BioCyci | EcoCyc:G7093-MONOMER |
SABIO-RKi | P0AAB6 |
Miscellaneous databases
PROi | PR:P0AAB6 |
Family and domain databases
CDDi | cd02541, UGPase_prokaryotic, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR005774, GalF IPR005771, GalU_uridylyltTrfase_bac/arc IPR005835, NTP_transferase_dom IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR43197, PTHR43197, 1 hit |
Pfami | View protein in Pfam PF00483, NTP_transferase, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
TIGRFAMsi | TIGR01105, galF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GALF_ECOLI | |
Accessioni | P0AAB6Primary (citable) accession number: P0AAB6 Secondary accession number(s): P71245, P78083, P97192 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | February 10, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families