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Entry version 103 (12 Aug 2020)
Sequence version 1 (13 Sep 2005)
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Protein

Cytosine permease

Gene

codB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for cytosine transport into the cell.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCytosine metabolism, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:CODB-MONOMER
ECOL316407:JW0327-MONOMER
MetaCyc:CODB-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.39.1.1, the nucleobase:cation symporter-1 (ncs1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosine permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:codB
Ordered Locus Names:b0336, JW0327
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19Cytoplasmic1 PublicationAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 39Helical; Name=1CuratedAdd BLAST20
Topological domaini40 – 51Periplasmic1 PublicationAdd BLAST12
Transmembranei52 – 71Helical; Name=2CuratedAdd BLAST20
Topological domaini72 – 100Cytoplasmic1 PublicationAdd BLAST29
Transmembranei101 – 120Helical; Name=3CuratedAdd BLAST20
Topological domaini121 – 127Periplasmic1 Publication7
Transmembranei128 – 147Helical; Name=4CuratedAdd BLAST20
Topological domaini148 – 152Cytoplasmic1 Publication5
Transmembranei153 – 172Helical; Name=5CuratedAdd BLAST20
Topological domaini173 – 192Periplasmic1 PublicationAdd BLAST20
Transmembranei193 – 212Helical; Name=6CuratedAdd BLAST20
Topological domaini213 – 221Cytoplasmic1 Publication9
Transmembranei222 – 242Helical; Name=7CuratedAdd BLAST21
Topological domaini243 – 257Periplasmic1 PublicationAdd BLAST15
Transmembranei258 – 277Helical; Name=8CuratedAdd BLAST20
Topological domaini278 – 300Cytoplasmic1 PublicationAdd BLAST23
Transmembranei301 – 320Helical; Name=9CuratedAdd BLAST20
Topological domaini321Periplasmic1 Publication1
Transmembranei322 – 341Helical; Name=10CuratedAdd BLAST20
Topological domaini342 – 358Cytoplasmic1 PublicationAdd BLAST17
Transmembranei359 – 378Helical; Name=11CuratedAdd BLAST20
Topological domaini379 – 380Periplasmic1 Publication2
Transmembranei381 – 400Helical; Name=12CuratedAdd BLAST20
Topological domaini401 – 419Cytoplasmic1 PublicationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001979321 – 419Cytosine permeaseAdd BLAST419

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AA82

PRoteomics IDEntifications database

More...
PRIDEi
P0AA82

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259812, 7 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0336

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1457, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035711_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AA82

KEGG Orthology (KO)

More...
KOi
K10974

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AA82

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030191, CodB
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30569, PTHR30569, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AA82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH
60 70 80 90 100
DFFLAVLIGN LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL
110 120 130 140 150
LGGTQVGWFG VGVAMFAIPV GKATGLDINL LIAVSGLLMT VTVFFGISAL
160 170 180 190 200
TVLSVIAVPA IACLGGYSVW LAVNGMGGLD ALKAVVPAQP LDFNVALALV
210 220 230 240 250
VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF IFGAAGAAAL
260 270 280 290 300
GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
310 320 330 340 350
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY
360 370 380 390 400
EHFATTRMMS VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP
410
ILNRKTTAAM THVEANSVE
Length:419
Mass (Da):43,650
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB1EDEBD84AA1D93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63656 Genomic DNA Translation: CAA45195.1
U73857 Genomic DNA Translation: AAB18060.1
U00096 Genomic DNA Translation: AAC73439.1
AP009048 Genomic DNA Translation: BAE76118.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S22661

NCBI Reference Sequences

More...
RefSeqi
NP_414870.1, NC_000913.3
WP_000076233.1, NZ_SSZK01000097.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73439; AAC73439; b0336
BAE76118; BAE76118; BAE76118

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
944994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0327
eco:b0336

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1941

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63656 Genomic DNA Translation: CAA45195.1
U73857 Genomic DNA Translation: AAB18060.1
U00096 Genomic DNA Translation: AAC73439.1
AP009048 Genomic DNA Translation: BAE76118.1
PIRiS22661
RefSeqiNP_414870.1, NC_000913.3
WP_000076233.1, NZ_SSZK01000097.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4259812, 7 interactors
STRINGi511145.b0336

Protein family/group databases

TCDBi2.A.39.1.1, the nucleobase:cation symporter-1 (ncs1) family

Proteomic databases

PaxDbiP0AA82
PRIDEiP0AA82

Genome annotation databases

EnsemblBacteriaiAAC73439; AAC73439; b0336
BAE76118; BAE76118; BAE76118
GeneIDi944994
KEGGiecj:JW0327
eco:b0336
PATRICifig|1411691.4.peg.1941

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1303

Phylogenomic databases

eggNOGiCOG1457, Bacteria
HOGENOMiCLU_035711_1_1_6
InParanoidiP0AA82
KOiK10974
PhylomeDBiP0AA82

Enzyme and pathway databases

BioCyciEcoCyc:CODB-MONOMER
ECOL316407:JW0327-MONOMER
MetaCyc:CODB-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AA82

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR030191, CodB
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf
PANTHERiPTHR30569, PTHR30569, 1 hit
PfamiView protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCODB_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AA82
Secondary accession number(s): P25525, Q2MC88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: August 12, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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