UniProtKB - P0AA82 (CODB_ECOLI)
Protein
Cytosine permease
Gene
codB
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for cytosine transport into the cell.
GO - Molecular functioni
- cytosine transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cytosine metabolic process Source: UniProtKB-KW
- cytosine transport Source: GO_Central
- proton transmembrane transport Source: GOC
Keywordsi
Biological process | Cytosine metabolism, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:CODB-MONOMER MetaCyc:CODB-MONOMER |
Protein family/group databases
TCDBi | 2.A.39.1.1, the nucleobase:cation symporter-1 (ncs1) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cytosine permease |
Gene namesi | Name:codB Ordered Locus Names:b0336, JW0327 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | Cytoplasmic1 PublicationAdd BLAST | 19 | |
Transmembranei | 20 – 39 | Helical; Name=1CuratedAdd BLAST | 20 | |
Topological domaini | 40 – 51 | Periplasmic1 PublicationAdd BLAST | 12 | |
Transmembranei | 52 – 71 | Helical; Name=2CuratedAdd BLAST | 20 | |
Topological domaini | 72 – 100 | Cytoplasmic1 PublicationAdd BLAST | 29 | |
Transmembranei | 101 – 120 | Helical; Name=3CuratedAdd BLAST | 20 | |
Topological domaini | 121 – 127 | Periplasmic1 Publication | 7 | |
Transmembranei | 128 – 147 | Helical; Name=4CuratedAdd BLAST | 20 | |
Topological domaini | 148 – 152 | Cytoplasmic1 Publication | 5 | |
Transmembranei | 153 – 172 | Helical; Name=5CuratedAdd BLAST | 20 | |
Topological domaini | 173 – 192 | Periplasmic1 PublicationAdd BLAST | 20 | |
Transmembranei | 193 – 212 | Helical; Name=6CuratedAdd BLAST | 20 | |
Topological domaini | 213 – 221 | Cytoplasmic1 Publication | 9 | |
Transmembranei | 222 – 242 | Helical; Name=7CuratedAdd BLAST | 21 | |
Topological domaini | 243 – 257 | Periplasmic1 PublicationAdd BLAST | 15 | |
Transmembranei | 258 – 277 | Helical; Name=8CuratedAdd BLAST | 20 | |
Topological domaini | 278 – 300 | Cytoplasmic1 PublicationAdd BLAST | 23 | |
Transmembranei | 301 – 320 | Helical; Name=9CuratedAdd BLAST | 20 | |
Topological domaini | 321 | Periplasmic1 Publication | 1 | |
Transmembranei | 322 – 341 | Helical; Name=10CuratedAdd BLAST | 20 | |
Topological domaini | 342 – 358 | Cytoplasmic1 PublicationAdd BLAST | 17 | |
Transmembranei | 359 – 378 | Helical; Name=11CuratedAdd BLAST | 20 | |
Topological domaini | 379 – 380 | Periplasmic1 Publication | 2 | |
Transmembranei | 381 – 400 | Helical; Name=12CuratedAdd BLAST | 20 | |
Topological domaini | 401 – 419 | Cytoplasmic1 PublicationAdd BLAST | 19 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197932 | 1 – 419 | Cytosine permeaseAdd BLAST | 419 |
Proteomic databases
PaxDbi | P0AA82 |
PRIDEi | P0AA82 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259812, 7 interactors |
STRINGi | 511145.b0336 |
Family & Domainsi
Sequence similaritiesi
Belongs to the purine-cytosine permease (2.A.39) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1457, Bacteria |
HOGENOMi | CLU_035711_1_1_6 |
InParanoidi | P0AA82 |
PhylomeDBi | P0AA82 |
Family and domain databases
Gene3Di | 1.10.4160.10, 1 hit |
InterProi | View protein in InterPro IPR030191, CodB IPR001248, Pur-cyt_permease IPR038271, Pur-cyt_permease_sf |
PANTHERi | PTHR30569, PTHR30569, 1 hit |
Pfami | View protein in Pfam PF02133, Transp_cyt_pur, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AA82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH
60 70 80 90 100
DFFLAVLIGN LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL
110 120 130 140 150
LGGTQVGWFG VGVAMFAIPV GKATGLDINL LIAVSGLLMT VTVFFGISAL
160 170 180 190 200
TVLSVIAVPA IACLGGYSVW LAVNGMGGLD ALKAVVPAQP LDFNVALALV
210 220 230 240 250
VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF IFGAAGAAAL
260 270 280 290 300
GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
310 320 330 340 350
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY
360 370 380 390 400
EHFATTRMMS VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP
410
ILNRKTTAAM THVEANSVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63656 Genomic DNA Translation: CAA45195.1 U73857 Genomic DNA Translation: AAB18060.1 U00096 Genomic DNA Translation: AAC73439.1 AP009048 Genomic DNA Translation: BAE76118.1 |
PIRi | S22661 |
RefSeqi | NP_414870.1, NC_000913.3 WP_000076233.1, NZ_SSZK01000097.1 |
Genome annotation databases
EnsemblBacteriai | AAC73439; AAC73439; b0336 BAE76118; BAE76118; BAE76118 |
GeneIDi | 944994 |
KEGGi | ecj:JW0327 eco:b0336 |
PATRICi | fig|1411691.4.peg.1941 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63656 Genomic DNA Translation: CAA45195.1 U73857 Genomic DNA Translation: AAB18060.1 U00096 Genomic DNA Translation: AAC73439.1 AP009048 Genomic DNA Translation: BAE76118.1 |
PIRi | S22661 |
RefSeqi | NP_414870.1, NC_000913.3 WP_000076233.1, NZ_SSZK01000097.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259812, 7 interactors |
STRINGi | 511145.b0336 |
Protein family/group databases
TCDBi | 2.A.39.1.1, the nucleobase:cation symporter-1 (ncs1) family |
Proteomic databases
PaxDbi | P0AA82 |
PRIDEi | P0AA82 |
Genome annotation databases
EnsemblBacteriai | AAC73439; AAC73439; b0336 BAE76118; BAE76118; BAE76118 |
GeneIDi | 944994 |
KEGGi | ecj:JW0327 eco:b0336 |
PATRICi | fig|1411691.4.peg.1941 |
Organism-specific databases
EchoBASEi | EB1303 |
Phylogenomic databases
eggNOGi | COG1457, Bacteria |
HOGENOMi | CLU_035711_1_1_6 |
InParanoidi | P0AA82 |
PhylomeDBi | P0AA82 |
Enzyme and pathway databases
BioCyci | EcoCyc:CODB-MONOMER MetaCyc:CODB-MONOMER |
Miscellaneous databases
PROi | PR:P0AA82 |
Family and domain databases
Gene3Di | 1.10.4160.10, 1 hit |
InterProi | View protein in InterPro IPR030191, CodB IPR001248, Pur-cyt_permease IPR038271, Pur-cyt_permease_sf |
PANTHERi | PTHR30569, PTHR30569, 1 hit |
Pfami | View protein in Pfam PF02133, Transp_cyt_pur, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CODB_ECOLI | |
Accessioni | P0AA82Primary (citable) accession number: P0AA82 Secondary accession number(s): P25525, Q2MC88 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | September 13, 2005 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families