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UniProtKB - P0AA76 (DGOT_ECOLI)

Entry version 111 (02 Dec 2020)
Sequence version 1 (13 Sep 2005)
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Protein

D-galactonate transporter

Gene

dgoT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intake of galactonate into the cell.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:YIDT-MONOMER
MetaCyc:YIDT-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.14.7, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D-galactonate transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dgoT
Synonyms:yidT
Ordered Locus Names:b3691, JW5859
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17PeriplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 54CytoplasmicSequence analysisAdd BLAST16
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 84PeriplasmicSequence analysis9
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 142CytoplasmicSequence analysisAdd BLAST37
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 167PeriplasmicSequence analysis4
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 242CytoplasmicSequence analysisAdd BLAST54
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 283PeriplasmicSequence analysisAdd BLAST20
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 309CytoplasmicSequence analysis5
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 337PeriplasmicSequence analysis7
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 375CytoplasmicSequence analysisAdd BLAST17
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 403PeriplasmicSequence analysis7
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 430CytoplasmicSequence analysis6

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001213771 – 430D-galactonate transporterAdd BLAST430

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0AA76

PRoteomics IDEntifications database

More...PRIDEi		P0AA76

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263278, 7 interactors

Database of interacting proteins

More...DIPi		DIP-9436N

STRING: functional protein association networks

More...STRINGi		511145.b3691

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0AA76

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Phthalate permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2271, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001265_5_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0AA76

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0AA76

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AA76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIPVNAAKP GRRRYLTLVM IFITVVICYV DRANLAVASA HIQEEFGITK 
        60         70         80         90        100
AEMGYVFSAF AWLYTLCQIP GGWFLDRVGS RVTYFIAIFG WSVATLFQGF 
       110        120        130        140        150
ATGLMSLIGL RAITGIFEAP AFPTNNRMVT SWFPEHERAS AVGFYTSGQF 
       160        170        180        190        200
VGLAFLTPLL IWIQEMLSWH WVFIVTGGIG IIWSLIWFKV YQPPRLTKGI 
       210        220        230        240        250
SKAELDYIRD GGGLVDGDAP VKKEARQPLT AKDWKLVFHR KLIGVYLGQF 
       260        270        280        290        300
AVASTLWFFL TWFPNYLTQE KGITALKAGF MTTVPFLAAF VGVLLSGWVA 
       310        320        330        340        350
DLLVRKGFSL GFARKTPIIC GLLISTCIMG ANYTNDPMMI MCLMALAFFG 
       360        370        380        390        400
NGFASITWSL VSSLAPMRLI GLTGGVFNFA GGLGGITVPL VVGYLAQGYG 
       410        420        430
FAPALVYISA VALIGALSYI LLVGDVKRVG
Length:430
Mass (Da):47,077
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86B1902777F2E461
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA62043 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62043.1 Different initiation.
U00096 Genomic DNA Translation: AAC76714.2
AP009048 Genomic DNA Translation: BAE77603.1

Protein sequence database of the Protein Information Resource

More...PIRi		D65171

NCBI Reference Sequences

More...RefSeqi		NP_418146.4, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76714; AAC76714; b3691
BAE77603; BAE77603; BAE77603

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5859
eco:b3691

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.3814

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62043.1 Different initiation.
U00096 Genomic DNA Translation: AAC76714.2
AP009048 Genomic DNA Translation: BAE77603.1
PIRiD65171
RefSeqiNP_418146.4, NC_000913.3

3D structure databases

SMRiP0AA76
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4263278, 7 interactors
DIPiDIP-9436N
STRINGi511145.b3691

Protein family/group databases

TCDBi2.A.1.14.7, the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiP0AA76
PRIDEiP0AA76

Genome annotation databases

EnsemblBacteriaiAAC76714; AAC76714; b3691
BAE77603; BAE77603; BAE77603
GeneIDi948196
KEGGiecj:JW5859
eco:b3691
PATRICifig|511145.12.peg.3814

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1666

Phylogenomic databases

eggNOGiCOG2271, Bacteria
HOGENOMiCLU_001265_5_1_6
InParanoidiP0AA76
PhylomeDBiP0AA76

Enzyme and pathway databases

BioCyciEcoCyc:YIDT-MONOMER
MetaCyc:YIDT-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0AA76

Family and domain databases

InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGOT_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AA76
Secondary accession number(s): P31457, Q2M803
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: December 2, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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