UniProtKB - P0AA29 (THIO_SALTI)
Protein
Thioredoxin 1
Gene
trxA
Organism
Salmonella typhi
Status
Functioni
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 27 | Deprotonates C-terminal active site CysBy similarity | 1 | |
Active sitei | 33 | NucleophileBy similarity | 1 | |
Sitei | 34 | Contributes to redox potential valueBy similarity | 1 | |
Sitei | 35 | Contributes to redox potential valueBy similarity | 1 | |
Active sitei | 36 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- protein disulfide oxidoreductase activity Source: InterPro
GO - Biological processi
- cell redox homeostasis Source: InterPro
- glycerol ether metabolic process Source: InterPro
Keywordsi
Biological process | Electron transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Thioredoxin 1Short name: Trx-1 |
Gene namesi | Name:trxA Ordered Locus Names:STY3639, t3381 |
Organismi | Salmonella typhi |
Taxonomic identifieri | 90370 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000120099 | 2 – 109 | Thioredoxin 1Add BLAST | 108 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 36 | Redox-activePROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 220341.16504518 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P0AA29 |
SMRi | P0AA29 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 109 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 108 |
Sequence similaritiesi
Belongs to the thioredoxin family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | COG3118, Bacteria |
HOGENOMi | CLU_090389_10_2_6 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AA29-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY
60 70 80 90 100
QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL
KEFLDANLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL513382 Genomic DNA Translation: CAD09400.1 AE014613 Genomic DNA Translation: AAO70905.1 |
RefSeqi | NP_457831.1, NC_003198.1 WP_001280776.1, NZ_WSUR01000032.1 |
Genome annotation databases
EnsemblBacteriai | AAO70905; AAO70905; t3381 |
GeneIDi | 58459597 |
KEGGi | stt:t3381 sty:STY3639 |
PATRICi | fig|220341.7.peg.3708 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL513382 Genomic DNA Translation: CAD09400.1 AE014613 Genomic DNA Translation: AAO70905.1 |
RefSeqi | NP_457831.1, NC_003198.1 WP_001280776.1, NZ_WSUR01000032.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M7T | NMR | - | A | 87-108 | [»] | |
BMRBi | P0AA29 | |||||
SMRi | P0AA29 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 220341.16504518 |
Genome annotation databases
EnsemblBacteriai | AAO70905; AAO70905; t3381 |
GeneIDi | 58459597 |
KEGGi | stt:t3381 sty:STY3639 |
PATRICi | fig|220341.7.peg.3708 |
Phylogenomic databases
eggNOGi | COG3118, Bacteria |
HOGENOMi | CLU_090389_10_2_6 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THIO_SALTI | |
Accessioni | P0AA29Primary (citable) accession number: P0AA29 Secondary accession number(s): P00274 Q8XAT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families