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UniProtKB - P0AA26 (THIO_ECOL6)
Protein
Thioredoxin 1
Gene
trxA
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Functioni
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 27 | Deprotonates C-terminal active site CysBy similarity | 1 | |
Active sitei | 33 | NucleophileBy similarity | 1 | |
Sitei | 34 | Contributes to redox potential valueBy similarity | 1 | |
Sitei | 35 | Contributes to redox potential valueBy similarity | 1 | |
Active sitei | 36 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- protein-disulfide reductase activity Source: InterPro
Keywordsi
Biological process | Electron transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Thioredoxin 1Short name: Trx-1 |
Gene namesi | Name:trxA Ordered Locus Names:c4701 |
Organismi | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) |
Taxonomic identifieri | 199310 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000120097 | 2 – 109 | Thioredoxin 1Add BLAST | 108 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 36 | Redox-activePROSITE-ProRule annotation | ||
Modified residuei | 70 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Disulfide bondInteractioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 199310.c4701 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 109 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 108 |
Sequence similaritiesi
Belongs to the thioredoxin family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | COG3118, Bacteria |
HOGENOMi | CLU_090389_10_2_6 |
OMAi | QVGVAPK |
Family and domain databases
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AA26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY
60 70 80 90 100
QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL
KEFLDANLA
Sequence cautioni
The sequence AAN83133 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN83133.1 Different initiation. |
RefSeqi | WP_001280776.1, NC_004431.1 |
Genome annotation databases
EnsemblBacteriai | AAN83133; AAN83133; c4701 |
GeneIDi | 64173577 67514182 |
KEGGi | ecc:c4701 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN83133.1 Different initiation. |
RefSeqi | WP_001280776.1, NC_004431.1 |
3D structure databases
AlphaFoldDBi | P0AA26 |
BMRBi | P0AA26 |
SMRi | P0AA26 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 199310.c4701 |
Genome annotation databases
EnsemblBacteriai | AAN83133; AAN83133; c4701 |
GeneIDi | 64173577 67514182 |
KEGGi | ecc:c4701 |
Phylogenomic databases
eggNOGi | COG3118, Bacteria |
HOGENOMi | CLU_090389_10_2_6 |
OMAi | QVGVAPK |
Family and domain databases
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THIO_ECOL6 | |
Accessioni | P0AA26Primary (citable) accession number: P0AA26 Secondary accession number(s): P00274 Q8XAT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 89 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |