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Entry version 137 (08 May 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Thioredoxin 1

Gene

trxA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei27Deprotonates C-terminal active site Cys1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei33Nucleophile1
Sitei34Contributes to redox potential value1
Sitei35Contributes to redox potential value1
Active sitei36Nucleophile1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: EcoCyc
  • glycerol ether metabolic process Source: InterPro
  • viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Host-virus interaction, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:RED-THIOREDOXIN-MONOMER
ECOL316407:JW5856-MONOMER
MetaCyc:RED-THIOREDOXIN-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thioredoxin 1
Short name:
Trx-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trxA
Synonyms:fipA, tsnC
Ordered Locus Names:b3781, JW5856
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG11031 trxA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001200962 – 109Thioredoxin 1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 36Redox-activePROSITE-ProRule annotation1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei70N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0AA25

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0AA25

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AA25

PRoteomics IDEntifications database

More...
PRIDEi
P0AA25

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P0AA25

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P0AA25

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0AA25

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with bacteriophage T3 DNA polymerase.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4263316, 300 interactors

Database of interacting proteins

More...
DIPi
DIP-31856N

Protein interaction database and analysis system

More...
IntActi
P0AA25, 99 interactors

Molecular INTeraction database

More...
MINTi
P0AA25

STRING: functional protein association networks

More...
STRINGi
511145.b3781

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F6MX-ray2.95C/D/G/H2-109[»]
1KEBX-ray1.80A/B2-109[»]
1M7TNMR-A32-108[»]
1OAZX-ray2.78A/B2-109[»]
1SKRX-ray2.40B2-109[»]
1SKSX-ray2.30B2-109[»]
1SKWX-ray2.30B2-109[»]
1SL0X-ray3.20B/D2-109[»]
1SL1X-ray2.20B2-109[»]
1SL2X-ray2.30B2-109[»]
1SRXX-ray2.80A2-109[»]
1T7PX-ray2.20B2-109[»]
1T8EX-ray2.54B2-109[»]
1THOX-ray2.30A2-109[»]
1TK0X-ray2.30B2-109[»]
1TK5X-ray2.20B2-109[»]
1TK8X-ray2.50B2-109[»]
1TKDX-ray2.49B2-109[»]
1TXXX-ray2.20A2-109[»]
1X9MX-ray2.10B2-109[»]
1X9SX-ray2.70B2-109[»]
1X9WX-ray2.30B2-109[»]
1XOANMR-A2-109[»]
1XOBNMR-A2-109[»]
1ZCPX-ray2.30A/B/C/D2-109[»]
1ZYQX-ray2.70B2-109[»]
1ZZYX-ray2.50A/B2-109[»]
2AJQX-ray2.60B/I2-109[»]
2BTOX-ray2.50T2-109[»]
2EIOX-ray2.60A/B/C/D2-109[»]
2EIQX-ray1.90A/B2-109[»]
2EIRX-ray2.50A/B/C/D2-109[»]
2FCHX-ray2.60A/B/C/D/E/F/G2-109[»]
2FD3X-ray2.45A/B2-109[»]
2H6XX-ray2.60A/B2-109[»]
2H6YX-ray2.40A/B2-109[»]
2H6ZX-ray2.25A/B2-109[»]
2H70X-ray2.70A/B2-109[»]
2H71X-ray2.20A/B2-109[»]
2H72X-ray2.25A/B2-109[»]
2H73X-ray2.45A/B2-109[»]
2H74X-ray2.40A/B4-109[»]
2H75X-ray2.20A/B2-109[»]
2H76X-ray2.25A/B2-109[»]
2O8VX-ray3.00B2-109[»]
2TIRX-ray2.00A2-109[»]
2TRXX-ray1.68A/B2-109[»]
3DYRX-ray2.00A/B2-109[»]
4HU7X-ray1.40A/B2-109[»]
4HU9X-ray1.55A2-109[»]
4HUAX-ray1.10A2-109[»]
4X43X-ray1.65A/B/C2-109[»]
5HR0X-ray1.31A/B1-109[»]
5HR1X-ray2.14A/B/C/D/E/F/G1-107[»]
5HR2X-ray1.20A1-109[»]
5HR3X-ray1.10A/B1-109[»]
5XOCX-ray2.40B2-109[»]
6GD1X-ray2.01A/B1-109[»]
6GDGelectron microscopy4.11A2-109[»]
6H7JX-ray2.80E/F2-109[»]
6H7LX-ray2.70E/F2-109[»]
6H7MX-ray2.76E/F2-109[»]
6H7NX-ray2.50E/F2-109[»]
6H7OX-ray2.80E/F2-109[»]
6IBLX-ray2.70A/B2-109[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0AA25

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0AA25

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 109ThioredoxinPROSITE-ProRule annotationAdd BLAST108

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0526 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000292977

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AA25

KEGG Orthology (KO)

More...
KOi
K03671

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AA25

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00085 Thioredoxin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000077 Thioredoxin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01068 thioredoxin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0AA25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY
60 70 80 90 100
QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL

KEFLDANLA
Length:109
Mass (Da):11,807
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF5933EA29668EE9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA24534 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA67582 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72 – 73GI → IG AA sequence (PubMed:4883076).Curated2
Sequence conflicti88A → AS in AAA24696 (PubMed:1379743).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M26133 Genomic DNA Translation: AAA24693.1
K02845 Genomic DNA Translation: AAA24534.1 Different initiation.
M10424 Genomic DNA Translation: AAA24533.1
M54881 Genomic DNA Translation: AAA24696.1
M12779 Genomic DNA Translation: AAA24694.1
M87049 Genomic DNA Translation: AAA67582.1 Different initiation.
U00096 Genomic DNA Translation: AAC76786.2
AP009048 Genomic DNA Translation: BAE77517.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A91519 TXEC

NCBI Reference Sequences

More...
RefSeqi
NP_418228.2, NC_000913.3
WP_001280776.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76786; AAC76786; b3781
BAE77517; BAE77517; BAE77517

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23335415
948289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5856
eco:b3781

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.3896

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26133 Genomic DNA Translation: AAA24693.1
K02845 Genomic DNA Translation: AAA24534.1 Different initiation.
M10424 Genomic DNA Translation: AAA24533.1
M54881 Genomic DNA Translation: AAA24696.1
M12779 Genomic DNA Translation: AAA24694.1
M87049 Genomic DNA Translation: AAA67582.1 Different initiation.
U00096 Genomic DNA Translation: AAC76786.2
AP009048 Genomic DNA Translation: BAE77517.1
PIRiA91519 TXEC
RefSeqiNP_418228.2, NC_000913.3
WP_001280776.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F6MX-ray2.95C/D/G/H2-109[»]
1KEBX-ray1.80A/B2-109[»]
1M7TNMR-A32-108[»]
1OAZX-ray2.78A/B2-109[»]
1SKRX-ray2.40B2-109[»]
1SKSX-ray2.30B2-109[»]
1SKWX-ray2.30B2-109[»]
1SL0X-ray3.20B/D2-109[»]
1SL1X-ray2.20B2-109[»]
1SL2X-ray2.30B2-109[»]
1SRXX-ray2.80A2-109[»]
1T7PX-ray2.20B2-109[»]
1T8EX-ray2.54B2-109[»]
1THOX-ray2.30A2-109[»]
1TK0X-ray2.30B2-109[»]
1TK5X-ray2.20B2-109[»]
1TK8X-ray2.50B2-109[»]
1TKDX-ray2.49B2-109[»]
1TXXX-ray2.20A2-109[»]
1X9MX-ray2.10B2-109[»]
1X9SX-ray2.70B2-109[»]
1X9WX-ray2.30B2-109[»]
1XOANMR-A2-109[»]
1XOBNMR-A2-109[»]
1ZCPX-ray2.30A/B/C/D2-109[»]
1ZYQX-ray2.70B2-109[»]
1ZZYX-ray2.50A/B2-109[»]
2AJQX-ray2.60B/I2-109[»]
2BTOX-ray2.50T2-109[»]
2EIOX-ray2.60A/B/C/D2-109[»]
2EIQX-ray1.90A/B2-109[»]
2EIRX-ray2.50A/B/C/D2-109[»]
2FCHX-ray2.60A/B/C/D/E/F/G2-109[»]
2FD3X-ray2.45A/B2-109[»]
2H6XX-ray2.60A/B2-109[»]
2H6YX-ray2.40A/B2-109[»]
2H6ZX-ray2.25A/B2-109[»]
2H70X-ray2.70A/B2-109[»]
2H71X-ray2.20A/B2-109[»]
2H72X-ray2.25A/B2-109[»]
2H73X-ray2.45A/B2-109[»]
2H74X-ray2.40A/B4-109[»]
2H75X-ray2.20A/B2-109[»]
2H76X-ray2.25A/B2-109[»]
2O8VX-ray3.00B2-109[»]
2TIRX-ray2.00A2-109[»]
2TRXX-ray1.68A/B2-109[»]
3DYRX-ray2.00A/B2-109[»]
4HU7X-ray1.40A/B2-109[»]
4HU9X-ray1.55A2-109[»]
4HUAX-ray1.10A2-109[»]
4X43X-ray1.65A/B/C2-109[»]
5HR0X-ray1.31A/B1-109[»]
5HR1X-ray2.14A/B/C/D/E/F/G1-107[»]
5HR2X-ray1.20A1-109[»]
5HR3X-ray1.10A/B1-109[»]
5XOCX-ray2.40B2-109[»]
6GD1X-ray2.01A/B1-109[»]
6GDGelectron microscopy4.11A2-109[»]
6H7JX-ray2.80E/F2-109[»]
6H7LX-ray2.70E/F2-109[»]
6H7MX-ray2.76E/F2-109[»]
6H7NX-ray2.50E/F2-109[»]
6H7OX-ray2.80E/F2-109[»]
6IBLX-ray2.70A/B2-109[»]
SMRiP0AA25
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263316, 300 interactors
DIPiDIP-31856N
IntActiP0AA25, 99 interactors
MINTiP0AA25
STRINGi511145.b3781

PTM databases

CarbonylDBiP0AA25
iPTMnetiP0AA25

2D gel databases

SWISS-2DPAGEiP0AA25

Proteomic databases

EPDiP0AA25
jPOSTiP0AA25
PaxDbiP0AA25
PRIDEiP0AA25

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76786; AAC76786; b3781
BAE77517; BAE77517; BAE77517
GeneIDi23335415
948289
KEGGiecj:JW5856
eco:b3781
PATRICifig|511145.12.peg.3896

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1024
EcoGeneiEG11031 trxA

Phylogenomic databases

eggNOGiCOG0526 LUCA
HOGENOMiHOG000292977
InParanoidiP0AA25
KOiK03671
PhylomeDBiP0AA25

Enzyme and pathway databases

BioCyciEcoCyc:RED-THIOREDOXIN-MONOMER
ECOL316407:JW5856-MONOMER
MetaCyc:RED-THIOREDOXIN-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0AA25

Protein Ontology

More...
PROi
PR:P0AA25

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHIO_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AA25
Secondary accession number(s): P00274
, P76750, Q2M889, Q47674, Q8XAT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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