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Protein

Phosphocarrier protein HPr

Gene

ptsH

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Pros-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Biological processi

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2454-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphocarrier protein HPr
Alternative name(s):
Histidine-containing protein
Gene namesi
Name:ptsH
Synonyms:hpr
Ordered Locus Names:STM2431
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078701 – 85Phosphocarrier protein HPrAdd BLAST85

Proteomic databases

PaxDbiP0AA07
PRIDEiP0AA07

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2431

Structurei

3D structure databases

ProteinModelPortaliP0AA07
SMRiP0AA07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 85HPrPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the HPr family.Curated

Phylogenomic databases

eggNOGiENOG4105KZ7 Bacteria
COG1925 LUCA
HOGENOMiHOG000278399
KOiK02784
OMAiRPGNEFV
PhylomeDBiP0AA07

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
IPR002114 PTS_HPr_Ser_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit
PS00589 PTS_HPR_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P0AA07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQQEVTITA PNGLHTRPAA QFVKEAKGFT SEITVTSNGK SASAKSLFKL
60 70 80
QTLGLTQGTV VTISAEGEDE QKAVEHLVKL MAELE
Length:85
Mass (Da):9,119
Last modified:April 1, 1988 - v1
Checksum:iE5C8879C0A95AD41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21450 Genomic DNA Translation: AAA27052.1
X14737 Genomic DNA Translation: CAA32865.1
AE006468 Genomic DNA Translation: AAL21325.1
PIRiC28181 WQEBPH
RefSeqiNP_461366.1, NC_003197.2
WP_000487600.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21325; AAL21325; STM2431
GeneIDi1253953
34152663
KEGGistm:STM2431
PATRICifig|99287.12.peg.2569

Similar proteinsi

Entry informationi

Entry nameiPTHP_SALTY
AccessioniPrimary (citable) accession number: P0AA07
Secondary accession number(s): P05525, P07006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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