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Protein

Phosphocarrier protein HPr

Gene

ptsH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Pros-phosphohistidine intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:PTSH-MONOMER
MetaCyc:PTSH-MONOMER

Protein family/group databases

TCDBi8.A.8.1.1 the phosphotransferase system hpr (hpr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphocarrier protein HPr
Alternative name(s):
Histidine-containing protein
Gene namesi
Name:ptsH
Synonyms:hpr
Ordered Locus Names:b2415, JW2408
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10788 ptsH

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078501 – 85Phosphocarrier protein HPrAdd BLAST85

Proteomic databases

EPDiP0AA04
PaxDbiP0AA04
PRIDEiP0AA04

2D gel databases

SWISS-2DPAGEiP0AA04

PTM databases

iPTMnetiP0AA04

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi4259700, 574 interactors
DIPiDIP-35731N
IntActiP0AA04, 10 interactors
MINTiP0AA04
STRINGi316385.ECDH10B_2580

Structurei

Secondary structure

185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0AA04
SMRiP0AA04
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AA04

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 85HPrPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the HPr family.Curated

Phylogenomic databases

eggNOGiCOG1925 LUCA
HOGENOMiHOG000278399
InParanoidiP0AA04
KOiK02784
PhylomeDBiP0AA04

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
IPR002114 PTS_HPr_Ser_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit
PS00589 PTS_HPR_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P0AA04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQQEVTITA PNGLHTRPAA QFVKEAKGFT SEITVTSNGK SASAKSLFKL
60 70 80
QTLGLTQGTV VTISAEGEDE QKAVEHLVKL MAELE
Length:85
Mass (Da):9,119
Last modified:April 1, 1988 - v1
Checksum:iE5C8879C0A95AD41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10425 Genomic DNA Translation: AAA24438.1
J02796 Genomic DNA Translation: AAA24440.1
M21994 Genomic DNA Translation: AAA24384.1
M21451 Genomic DNA Translation: AAA23655.1
U00096 Genomic DNA Translation: AAC75468.1
AP009048 Genomic DNA Translation: BAA16289.1
PIRiA29785 WQECPH
RefSeqiNP_416910.1, NC_000913.3
WP_000487600.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75468; AAC75468; b2415
BAA16289; BAA16289; BAA16289
GeneIDi34152663
946886
KEGGiecj:JW2408
eco:b2415
PATRICifig|1411691.4.peg.4316

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10425 Genomic DNA Translation: AAA24438.1
J02796 Genomic DNA Translation: AAA24440.1
M21994 Genomic DNA Translation: AAA24384.1
M21451 Genomic DNA Translation: AAA23655.1
U00096 Genomic DNA Translation: AAC75468.1
AP009048 Genomic DNA Translation: BAA16289.1
PIRiA29785 WQECPH
RefSeqiNP_416910.1, NC_000913.3
WP_000487600.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CM2X-ray1.80A1-85[»]
1CM3X-ray1.60A1-85[»]
1GGRNMR-B1-85[»]
1HDNNMR-A1-85[»]
1J6TNMR-B1-85[»]
1OPDX-ray1.50A1-85[»]
1PFHNMR-A1-85[»]
1POHX-ray2.00A1-85[»]
1VRCNMR-C/D1-85[»]
2JELX-ray2.50P1-85[»]
2LRKNMR-D1-85[»]
2LRLNMR-D1-85[»]
2XDFNMR-C/D1-85[»]
3CCDX-ray1.00A/B1-85[»]
3EZANMR-B1-85[»]
3EZBNMR-B1-85[»]
3EZENMR-B1-85[»]
4XWJX-ray2.10B1-85[»]
5YA0X-ray3.00C/D1-85[»]
5YA1X-ray2.70C/D1-85[»]
5YA2X-ray2.70C/D1-85[»]
ProteinModelPortaliP0AA04
SMRiP0AA04
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259700, 574 interactors
DIPiDIP-35731N
IntActiP0AA04, 10 interactors
MINTiP0AA04
STRINGi316385.ECDH10B_2580

Protein family/group databases

TCDBi8.A.8.1.1 the phosphotransferase system hpr (hpr) family

PTM databases

iPTMnetiP0AA04

2D gel databases

SWISS-2DPAGEiP0AA04

Proteomic databases

EPDiP0AA04
PaxDbiP0AA04
PRIDEiP0AA04

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75468; AAC75468; b2415
BAA16289; BAA16289; BAA16289
GeneIDi34152663
946886
KEGGiecj:JW2408
eco:b2415
PATRICifig|1411691.4.peg.4316

Organism-specific databases

EchoBASEiEB0781
EcoGeneiEG10788 ptsH

Phylogenomic databases

eggNOGiCOG1925 LUCA
HOGENOMiHOG000278399
InParanoidiP0AA04
KOiK02784
PhylomeDBiP0AA04

Enzyme and pathway databases

BioCyciEcoCyc:PTSH-MONOMER
MetaCyc:PTSH-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0AA04
PROiPR:P0AA04

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
IPR002114 PTS_HPr_Ser_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit
PS00589 PTS_HPR_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTHP_ECOLI
AccessioniPrimary (citable) accession number: P0AA04
Secondary accession number(s): P05525, P07006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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