UniProtKB - P0A9X1 (ZNUC_ECOLI)
Protein
Zinc import ATP-binding protein ZnuC
Gene
znuC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.UniRule annotation1 Publication
Catalytic activityi
- ATP(in) + H2O(in) + Zn2+(out) = ADP(in) + H+(in) + phosphate(in) + Zn2+(in)UniRule annotation1 PublicationEC:7.2.2.20UniRule annotation1 Publication
Activity regulationi
Inhibited by arsenate.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 37 – 44 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATPase-coupled zinc transmembrane transporter activity Source: UniProtKB-UniRule
- ATP binding Source: EcoCyc
GO - Biological processi
- response to zinc ion Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Transport, Zinc transport |
Ligand | ATP-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:ZNUC-MONOMER MetaCyc:ZNUC-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.15.5, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc import ATP-binding protein ZnuCUniRule annotation (EC:7.2.2.20UniRule annotation1 Publication) |
Gene namesi | Name:znuCUniRule annotation Synonyms:yebM Ordered Locus Names:b1858, JW1847 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- ATP-binding cassette (ABC) transporter complex Source: GO_Central
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093130 | 1 – 251 | Zinc import ATP-binding protein ZnuCAdd BLAST | 251 |
Proteomic databases
PaxDbi | P0A9X1 |
PRIDEi | P0A9X1 |
Expressioni
Inductioni
Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations.2 Publications
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).
UniRule annotationProtein-protein interaction databases
BioGRIDi | 4263224, 5 interactors |
ComplexPortali | CPX-4407, Zinc ABC transporter complex |
DIPi | DIP-48234N |
IntActi | P0A9X1, 13 interactors |
STRINGi | 511145.b1858 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 220 | ABC transporterUniRule annotationAdd BLAST | 216 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. [View classification]UniRule annotation
Phylogenomic databases
eggNOGi | COG1121, Bacteria |
HOGENOMi | CLU_000604_1_11_6 |
InParanoidi | P0A9X1 |
PhylomeDBi | P0A9X1 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR027417, P-loop_NTPase IPR017882, ZnuC |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit PS51298, ZNUC, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A9X1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSLVSLENV SVSFGQRRVL SDVSLELKPG KILTLLGPNG AGKSTLVRVV
60 70 80 90 100
LGLVTPDEGV IKRNGKLRIG YVPQKLYLDT TLPLTVNRFL RLRPGTHKED
110 120 130 140 150
ILPALKRVQA GHLINAPMQK LSGGETQRVL LARALLNRPQ LLVLDEPTQG
160 170 180 190 200
VDVNGQVALY DLIDQLRREL DCGVLMVSHD LHLVMAKTDE VLCLNHHICC
210 220 230 240 250
SGTPEVVSLH PEFISMFGPR GAEQLGIYRH HHNHRHDLQG RIVLRRGNDR
S
Sequence cautioni
The sequence U38702 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 – 83 | TTLP → STLS in U38702 (Ref. 1) Curated | 4 | |
Sequence conflicti | 135 | L → W in U38702 (Ref. 1) Curated | 1 | |
Sequence conflicti | 143 | V → A in U38702 (Ref. 1) Curated | 1 | |
Sequence conflicti | 155 | G → W in U38702 (Ref. 1) Curated | 1 | |
Sequence conflicti | 174 – 176 | VLM → ALL in U38702 (Ref. 1) Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38702 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC74928.1 AP009048 Genomic DNA Translation: BAA15666.1 |
PIRi | B64948 |
RefSeqi | NP_416372.1, NC_000913.3 WP_000202996.1, NZ_STEB01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC74928; AAC74928; b1858 BAA15666; BAA15666; BAA15666 |
GeneIDi | 57731256 946374 |
KEGGi | ecj:JW1847 eco:b1858 |
PATRICi | fig|1411691.4.peg.390 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38702 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC74928.1 AP009048 Genomic DNA Translation: BAA15666.1 |
PIRi | B64948 |
RefSeqi | NP_416372.1, NC_000913.3 WP_000202996.1, NZ_STEB01000009.1 |
3D structure databases
SMRi | P0A9X1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263224, 5 interactors |
ComplexPortali | CPX-4407, Zinc ABC transporter complex |
DIPi | DIP-48234N |
IntActi | P0A9X1, 13 interactors |
STRINGi | 511145.b1858 |
Protein family/group databases
TCDBi | 3.A.1.15.5, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P0A9X1 |
PRIDEi | P0A9X1 |
Genome annotation databases
EnsemblBacteriai | AAC74928; AAC74928; b1858 BAA15666; BAA15666; BAA15666 |
GeneIDi | 57731256 946374 |
KEGGi | ecj:JW1847 eco:b1858 |
PATRICi | fig|1411691.4.peg.390 |
Organism-specific databases
EchoBASEi | EB2931 |
Phylogenomic databases
eggNOGi | COG1121, Bacteria |
HOGENOMi | CLU_000604_1_11_6 |
InParanoidi | P0A9X1 |
PhylomeDBi | P0A9X1 |
Enzyme and pathway databases
BioCyci | EcoCyc:ZNUC-MONOMER MetaCyc:ZNUC-MONOMER |
Miscellaneous databases
PROi | PR:P0A9X1 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR027417, P-loop_NTPase IPR017882, ZnuC |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit PS51298, ZNUC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNUC_ECOLI | |
Accessioni | P0A9X1Primary (citable) accession number: P0A9X1 Secondary accession number(s): P52648, P76285 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 10, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families