znuC

Functionⁱ

Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.UniRule annotation1 Publication

Catalytic activityⁱ

ATP(in) + H₂O(in) + Zn²⁺(out) = ADP(in) + H⁺(in) + phosphate(in) + Zn²⁺(in).UniRule annotation1 Publication

Activity regulationⁱ

Inhibited by arsenate.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	37 – 44	ATPUniRule annotation		8

GO - Molecular functionⁱ

ATPase activity Source: InterPro
ATP binding
Source: EcoCyc
Inferred from sequence modelⁱ
- 9593292
zinc-transporting ATPase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

response to zinc ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Ion transport, Transport, Zinc transport
Ligand	ATP-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCycⁱ	EcoCyc:ZNUC-MONOMER MetaCyc:ZNUC-MONOMER

BioCycⁱ

EcoCyc:ZNUC-MONOMER
MetaCyc:ZNUC-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.15.5 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.15.5 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc import ATP-binding protein ZnuCUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesⁱ	Name:znuCUniRule annotation Synonyms:yebM Ordered Locus Names:b1858, JW1847
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG13132 znuC

EcoGeneⁱ

EG13132 znuC

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01725
; Peripheral membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01725

GO - Cellular componentⁱ

ATP-binding cassette (ABC) transporter complex
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093130	1 – 251	Zinc import ATP-binding protein ZnuCAdd BLAST		251

Proteomic databases

PaxDbⁱ	P0A9X1
PRIDEⁱ	P0A9X1

Expressionⁱ

Inductionⁱ

Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations.2 Publications

Interactionⁱ

Subunit structureⁱ

The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).UniRule annotation

Protein-protein interaction databases

BioGridⁱ	4263224, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-48234N
IntActⁱ	P0A9X1, 13 interactors
STRINGⁱ	316385.ECDH10B_1999

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0A9X1
SMRⁱ	P0A9X1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 220	ABC transporterUniRule annotationAdd BLAST		216

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105FDK Bacteria COG1121 LUCA
InParanoidⁱ	P0A9X1
KEGG Orthology (KO) More...KOⁱ	K09817
PhylomeDBⁱ	P0A9X1

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003439 ABC_transporter-like IPR027417 P-loop_NTPase IPR017882 ZnuC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50893 ABC_TRANSPORTER_2, 1 hit PS51298 ZNUC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0A9X1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTSLVSLENV SVSFGQRRVL SDVSLELKPG KILTLLGPNG AGKSTLVRVV 
        60         70         80         90        100
LGLVTPDEGV IKRNGKLRIG YVPQKLYLDT TLPLTVNRFL RLRPGTHKED 
       110        120        130        140        150
ILPALKRVQA GHLINAPMQK LSGGETQRVL LARALLNRPQ LLVLDEPTQG 
       160        170        180        190        200
VDVNGQVALY DLIDQLRREL DCGVLMVSHD LHLVMAKTDE VLCLNHHICC 
       210        220        230        240        250
SGTPEVVSLH PEFISMFGPR GAEQLGIYRH HHNHRHDLQG RIVLRRGNDR 

S

Length:251

Mass (Da):27,867

Last modified:July 19, 2005 - v1

Checksum:ⁱF4BF845AC3C7904C

GO

Sequence cautionⁱ

The sequence U38702 differs from that shown. Reason: Frameshift at position 188.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	80 – 83	TTLP → STLS in U38702 (Ref. 1) Curated	4
Sequence conflictⁱ	135	L → W in U38702 (Ref. 1) Curated	1
Sequence conflictⁱ	143	V → A in U38702 (Ref. 1) Curated	1
Sequence conflictⁱ	155	G → W in U38702 (Ref. 1) Curated	1
Sequence conflictⁱ	174 – 176	VLM → ALL in U38702 (Ref. 1) Curated	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U38702 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC74928.1 AP009048 Genomic DNA Translation: BAA15666.1
PIRⁱ	B64948
NCBI Reference Sequences More...RefSeqⁱ	NP_416372.1, NC_000913.3 WP_000202996.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC74928; AAC74928; b1858 BAA15666; BAA15666; BAA15666
GeneIDⁱ	946374
KEGGⁱ	ecj:JW1847 eco:b1858
PATRICⁱ	fig\|1411691.4.peg.390

Protein	Similar proteins		Species	Score	Length	Source
P0A9X1	Zinc import ATP-binding protein ZnuC		ECO57		251	UniRef100_P0A9X3
Zinc import ATP-binding protein ZnuC		ECOK1		251
Zinc import ATP-binding protein ZnuC		ECOL5		251
Zinc import ATP-binding protein ZnuC		ECOL6		251
Zinc import ATP-binding protein ZnuC		ECOUT		251
+126

Protein	Similar proteins		Species	Score	Length	Source
P0A9X1	Zinc import ATP-binding protein ZnuC		SALTY		251	UniRef90_Q8ZNV7
Zinc import ATP-binding protein ZnuC		SALCH		251
Zinc import ATP-binding protein ZnuC		SALPA		251
Zinc import ATP-binding protein ZnuC		ECO57		251
Zinc import ATP-binding protein ZnuC		ECOK1		251
+925

Protein	Similar proteins		Species	Score	Length	Source
P0A9X1	Zinc import ATP-binding protein ZnuC		SALTY		251	UniRef50_Q8ZNV7
Zinc import ATP-binding protein ZnuC		SALCH		251
Zinc import ATP-binding protein ZnuC		SALPA		251
Zinc import ATP-binding protein ZnuC		SHIDS		251
Zinc import ATP-binding protein ZnuC		SALTI		251
+2919

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U38702 Genomic DNA No translation available. U00096 Genomic DNA Translation: AAC74928.1 AP009048 Genomic DNA Translation: BAA15666.1
PIRⁱ	B64948
RefSeqⁱ	NP_416372.1, NC_000913.3 WP_000202996.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0A9X1
SMRⁱ	P0A9X1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4263224, 5 interactors
DIPⁱ	DIP-48234N
IntActⁱ	P0A9X1, 13 interactors
STRINGⁱ	316385.ECDH10B_1999

Protein family/group databases

TCDBⁱ	3.A.1.15.5 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.15.5 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P0A9X1
PRIDEⁱ	P0A9X1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74928; AAC74928; b1858 BAA15666; BAA15666; BAA15666
GeneIDⁱ	946374
KEGGⁱ	ecj:JW1847 eco:b1858
PATRICⁱ	fig\|1411691.4.peg.390

Organism-specific databases

EchoBASEⁱ	EB2931
EcoGeneⁱ	EG13132 znuC

Phylogenomic databases

eggNOGⁱ	ENOG4105FDK Bacteria COG1121 LUCA
InParanoidⁱ	P0A9X1
KOⁱ	K09817
PhylomeDBⁱ	P0A9X1

Enzyme and pathway databases

BioCycⁱ	EcoCyc:ZNUC-MONOMER MetaCyc:ZNUC-MONOMER

BioCycⁱ

EcoCyc:ZNUC-MONOMER
MetaCyc:ZNUC-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0A9X1

PROⁱ

PR:P0A9X1

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003439 ABC_transporter-like IPR027417 P-loop_NTPase IPR017882 ZnuC
Pfamⁱ	View protein in Pfam PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50893 ABC_TRANSPORTER_2, 1 hit PS51298 ZNUC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNUC_ECOLI
Accessionⁱ	P0A9X1Primary (citable) accession number: P0A9X1 Secondary accession number(s): P52648, P76285
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	July 19, 2005
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0A9X1 (ZNUC_ECOLI)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc import ATP-binding protein ZnuC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ