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UniProtKB - P0A9V1 (LPTB_ECOLI)
Protein
Lipopolysaccharide export system ATP-binding protein LptB
Gene
lptB
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.
3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 43 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- Gram-negative-bacterium-type cell outer membrane assembly Source: ComplexPortal
- lipopolysaccharide transport Source: ComplexPortal
- transmembrane transport Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:YHBG-MONOMER |
BRENDAi | 7.5.2.5, 2026 |
Protein family/group databases
TCDBi | 1.B.42.1.2, the outer membrane lipopolysaccharide export porin (lps-ep) family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lptB Synonyms:yhbG Ordered Locus Names:b3201, JW3168 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex Source: EcoCyc
- plasma membrane Source: EcoCyc
Other locations
- cytoplasm Source: UniProtKB-SubCell
- membrane Source: ComplexPortal
- transporter complex Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, Cytoplasm, MembranePathology & Biotechi
Disruption phenotypei
Results in an earlier growth arrest and onset of cell lethality.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000093178 | 2 – 241 | Lipopolysaccharide export system ATP-binding protein LptBAdd BLAST | 240 |
Proteomic databases
jPOSTi | P0A9V1 |
PaxDbi | P0A9V1 |
PRIDEi | P0A9V1 |
Expressioni
Inductioni
Transcriptionally regulated by sigma-E factor.1 Publication
Interactioni
Subunit structurei
Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
1 PublicationProtein-protein interaction databases
ComplexPortali | CPX-3861, lptBFG LPS ABC transporter complex |
DIPi | DIP-31876N |
IntActi | P0A9V1, 5 interactors |
MINTi | P0A9V1 |
STRINGi | 511145.b3201 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P0A9V1 |
SMRi | P0A9V1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 237 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 234 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family. [View classification]Curated
Phylogenomic databases
eggNOGi | COG1137, Bacteria |
HOGENOMi | CLU_000604_1_2_6 |
InParanoidi | P0A9V1 |
OMAi | LPMYQRA |
PhylomeDBi | P0A9V1 |
Family and domain databases
CDDi | cd03218, ABC_YhbG, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR032823, BCA_ABC_TP_C IPR030921, LPS_export_LptB IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF12399, BCA_ABC_TP_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR04406, LPS_export_lptB, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0A9V1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLTAKNLA KAYKGRRVVE DVSLTVNSGE IVGLLGPNGA GKTTTFYMVV
60 70 80 90 100
GIVPRDAGNI IIDDDDISLL PLHARARRGI GYLPQEASIF RRLSVYDNLM
110 120 130 140 150
AVLQIRDDLS AEQREDRANE LMEEFHIEHL RDSMGQSLSG GERRRVEIAR
160 170 180 190 200
ALAANPKFIL LDEPFAGVDP ISVIDIKRII EHLRDSGLGV LITDHNVRET
210 220 230 240
LAVCERAYIV SQGHLIAHGT PTEILQDEHV KRVYLGEDFR L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 – 57 | RDA → ARC in AAB60162 (PubMed:8444818).Curated | 3 | |
Sequence conflicti | 55 – 57 | RDA → ARC in BAA02314 (PubMed:8444818).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12938 Genomic DNA Translation: BAA02314.1 U12684 Genomic DNA Translation: AAB60162.1 U18997 Genomic DNA Translation: AAA58003.1 U00096 Genomic DNA Translation: AAC76233.1 AP009048 Genomic DNA Translation: BAE77245.1 |
PIRi | C65111 |
RefSeqi | NP_417668.1, NC_000913.3 WP_000224099.1, NZ_STEB01000012.1 |
Genome annotation databases
EnsemblBacteriai | AAC76233; AAC76233; b3201 BAE77245; BAE77245; BAE77245 |
GeneIDi | 67415965 947725 |
KEGGi | ecj:JW3168 eco:b3201 |
PATRICi | fig|1411691.4.peg.3530 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12938 Genomic DNA Translation: BAA02314.1 U12684 Genomic DNA Translation: AAB60162.1 U18997 Genomic DNA Translation: AAA58003.1 U00096 Genomic DNA Translation: AAC76233.1 AP009048 Genomic DNA Translation: BAE77245.1 |
PIRi | C65111 |
RefSeqi | NP_417668.1, NC_000913.3 WP_000224099.1, NZ_STEB01000012.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4P31 | X-ray | 2.05 | A/B | 2-241 | [»] | |
4P32 | X-ray | 1.55 | A/B | 2-241 | [»] | |
4P33 | X-ray | 1.65 | A/B | 2-241 | [»] | |
6B89 | X-ray | 2.00 | A/B | 2-241 | [»] | |
6B8B | X-ray | 1.95 | A | 2-241 | [»] | |
6MBN | X-ray | 1.96 | A/B | 2-241 | [»] | |
6MGF | X-ray | 2.98 | A | 1-241 | [»] | |
6MHU | electron microscopy | 4.00 | A/B | 1-241 | [»] | |
6MHZ | electron microscopy | 4.10 | A/B | 1-241 | [»] | |
6MI7 | electron microscopy | 4.20 | A/B | 1-241 | [»] | |
6MI8 | electron microscopy | 4.30 | A/B | 1-241 | [»] | |
AlphaFoldDBi | P0A9V1 | |||||
SMRi | P0A9V1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-3861, lptBFG LPS ABC transporter complex |
DIPi | DIP-31876N |
IntActi | P0A9V1, 5 interactors |
MINTi | P0A9V1 |
STRINGi | 511145.b3201 |
Protein family/group databases
TCDBi | 1.B.42.1.2, the outer membrane lipopolysaccharide export porin (lps-ep) family |
Proteomic databases
jPOSTi | P0A9V1 |
PaxDbi | P0A9V1 |
PRIDEi | P0A9V1 |
Genome annotation databases
EnsemblBacteriai | AAC76233; AAC76233; b3201 BAE77245; BAE77245; BAE77245 |
GeneIDi | 67415965 947725 |
KEGGi | ecj:JW3168 eco:b3201 |
PATRICi | fig|1411691.4.peg.3530 |
Organism-specific databases
EchoBASEi | EB1631 |
Phylogenomic databases
eggNOGi | COG1137, Bacteria |
HOGENOMi | CLU_000604_1_2_6 |
InParanoidi | P0A9V1 |
OMAi | LPMYQRA |
PhylomeDBi | P0A9V1 |
Enzyme and pathway databases
BioCyci | EcoCyc:YHBG-MONOMER |
BRENDAi | 7.5.2.5, 2026 |
Miscellaneous databases
PROi | PR:P0A9V1 |
Family and domain databases
CDDi | cd03218, ABC_YhbG, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR032823, BCA_ABC_TP_C IPR030921, LPS_export_LptB IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF12399, BCA_ABC_TP_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR04406, LPS_export_lptB, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LPTB_ECOLI | |
Accessioni | P0A9V1Primary (citable) accession number: P0A9V1 Secondary accession number(s): P31220, Q2M911 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families