UniProtKB - P0A9R7 (FTSE_ECOLI)
Protein
Cell division ATP-binding protein FtsE
Gene
ftsE
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 35 – 42 | ATP1 Publication | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: EcoliWiki
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: EcoliWiki
- response to antibiotic Source: EcoliWiki
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:FTSE-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.140.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division ATP-binding protein FtsECurated |
Gene namesi | Name:ftsE Ordered Locus Names:b3463, JW3428 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 2 Publications; Peripheral membrane protein 1 Publication; Cytoplasmic side Curated
Note: Associated with the membrane through an interaction with FtsX (PubMed:10048040). Localizes to the septal ring at the later stages of cell growth and remains there until division is complete (PubMed:14729705). This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI (PubMed:14729705).2 Publications
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: EcoCyc
- plasma membrane Source: GO_Central
Other locations
- cell division site Source: EcoliWiki
- cytoplasm Source: EcoliWiki
- extrinsic component of membrane Source: EcoliWiki
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Inactivation results in a filamented cellular morphology, but not in a temperature-sensitive phenotype.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 41 | K → R: Does not bind ATP. 1 Publication | 1 | |
Mutagenesisi | 49 | C → A: Prevents dimer formation. Does not alter ATP-binding. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092328 | 1 – 222 | Cell division ATP-binding protein FtsEAdd BLAST | 222 |
Proteomic databases
jPOSTi | P0A9R7 |
PaxDbi | P0A9R7 |
PRIDEi | P0A9R7 |
Interactioni
Subunit structurei
Binary interactionsi
P0A9R7
With | #Exp. | IntAct |
---|---|---|
ftsZ [P0A9A6] | 2 | EBI-550637,EBI-370963 |
Protein-protein interaction databases
BioGRIDi | 4260774, 393 interactors |
ComplexPortali | CPX-4602, FtsEX ABC cell division complex |
DIPi | DIP-47843N |
IntActi | P0A9R7, 29 interactors |
STRINGi | 511145.b3463 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 222 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 221 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily.Curated
Phylogenomic databases
eggNOGi | COG2884, Bacteria |
HOGENOMi | CLU_000604_1_22_6 |
InParanoidi | P0A9R7 |
PhylomeDBi | P0A9R7 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR005286, Cell_div_FtsE_ATP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02673, FtsE, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A9R7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRFEHVSKA YLGGRQALQG VTFHMQPGEM AFLTGHSGAG KSTLLKLICG
60 70 80 90 100
IERPSAGKIW FSGHDITRLK NREVPFLRRQ IGMIFQDHHL LMDRTVYDNV
110 120 130 140 150
AIPLIIAGAS GDDIRRRVSA ALDKVGLLDK AKNFPIQLSG GEQQRVGIAR
160 170 180 190 200
AVVNKPAVLL ADEPTGNLDD ALSEGILRLF EEFNRVGVTV LMATHDINLI
210 220
SRRSYRMLTL SDGHLHGGVG HE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04398 Genomic DNA Translation: CAA27985.1 U00039 Genomic DNA Translation: AAB18438.1 U00096 Genomic DNA Translation: AAC76488.1 AP009048 Genomic DNA Translation: BAE77830.1 |
PIRi | S03131, CEECFE |
RefSeqi | NP_417920.1, NC_000913.3 WP_000617723.1, NZ_STEB01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC76488; AAC76488; b3463 BAE77830; BAE77830; BAE77830 |
GeneIDi | 58462552 947968 |
KEGGi | ecj:JW3428 eco:b3463 |
PATRICi | fig|1411691.4.peg.3262 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04398 Genomic DNA Translation: CAA27985.1 U00039 Genomic DNA Translation: AAB18438.1 U00096 Genomic DNA Translation: AAC76488.1 AP009048 Genomic DNA Translation: BAE77830.1 |
PIRi | S03131, CEECFE |
RefSeqi | NP_417920.1, NC_000913.3 WP_000617723.1, NZ_STEB01000004.1 |
3D structure databases
SMRi | P0A9R7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260774, 393 interactors |
ComplexPortali | CPX-4602, FtsEX ABC cell division complex |
DIPi | DIP-47843N |
IntActi | P0A9R7, 29 interactors |
STRINGi | 511145.b3463 |
Protein family/group databases
TCDBi | 3.A.1.140.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P0A9R7 |
PaxDbi | P0A9R7 |
PRIDEi | P0A9R7 |
Genome annotation databases
EnsemblBacteriai | AAC76488; AAC76488; b3463 BAE77830; BAE77830; BAE77830 |
GeneIDi | 58462552 947968 |
KEGGi | ecj:JW3428 eco:b3463 |
PATRICi | fig|1411691.4.peg.3262 |
Organism-specific databases
EchoBASEi | EB0336 |
Phylogenomic databases
eggNOGi | COG2884, Bacteria |
HOGENOMi | CLU_000604_1_22_6 |
InParanoidi | P0A9R7 |
PhylomeDBi | P0A9R7 |
Enzyme and pathway databases
BioCyci | EcoCyc:FTSE-MONOMER |
Miscellaneous databases
PROi | PR:P0A9R7 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR005286, Cell_div_FtsE_ATP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02673, FtsE, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSE_ECOLI | |
Accessioni | P0A9R7Primary (citable) accession number: P0A9R7 Secondary accession number(s): P10115, Q2M7C6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 10, 2021 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families