ftsE

Functionⁱ

Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	35 – 42	ATP1 Publication		8

GO - Molecular functionⁱ

ATPase activity Source: InterPro
ATP binding
Source: EcoliWiki
Inferred from direct assayⁱ
- 10048040

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division
Source: EcoliWiki
Inferred from mutant phenotypeⁱ
- 4583216
- 9658012
response to antibiotic
Source: EcoliWiki
Inferred from mutant phenotypeⁱ
- 4583216

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:FTSE-MONOMER

BioCycⁱ

EcoCyc:FTSE-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.140.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.140.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division ATP-binding protein FtsECurated
Gene namesⁱ	Name:ftsE Ordered Locus Names:b3463, JW3428
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10340 ftsE

EcoGeneⁱ

EG10340 ftsE

Subcellular locationⁱ

Cell inner membrane
2 Publications
Manual assertion based on experiment inⁱ
- Ref.5
  "The Escherichia coli cell division proteins FtsY, FtsE and FtsX are inner membrane-associated."
  Gill D.R., Salmond G.P.
  Mol. Gen. Genet. 210:504-508(1987) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
- Ref.6
  "Molecular characterization of Escherichia coli FtsE and FtsX."
  de Leeuw E., Graham B., Phillips G.J., ten Hagen-Jongman C.M., Oudega B., Luirink J.
  Mol. Microbiol. 31:983-993(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBUNIT, INTERACTION WITH FTSX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, ATP-BINDING, MUTAGENESIS OF LYS-41 AND CYS-49.
; Peripheral membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Molecular characterization of Escherichia coli FtsE and FtsX."
  de Leeuw E., Graham B., Phillips G.J., ten Hagen-Jongman C.M., Oudega B., Luirink J.
  Mol. Microbiol. 31:983-993(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBUNIT, INTERACTION WITH FTSX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, ATP-BINDING, MUTAGENESIS OF LYS-41 AND CYS-49.
; Cytoplasmic side Curated

Note:

Associated with the membrane through an interaction with FtsX (PubMed:10048040). Localizes to the septal ring at the later stages of cell growth and remains there until division is complete (PubMed:14729705). This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI (PubMed:14729705).2 Publications

GO - Cellular componentⁱ

cell division site
Source: EcoliWiki
Inferred from direct assayⁱ
- 14729705
cytoplasm
Source: EcoliWiki
Inferred from direct assayⁱ
- 10048040
extrinsic component of cytoplasmic side of plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 10048040
extrinsic component of membrane
Source: EcoliWiki
Inferred from direct assayⁱ
- 10048040

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Inactivation results in a filamented cellular morphology, but not in a temperature-sensitive phenotype.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	41	K → R: Does not bind ATP. 1 Publication		1
Mutagenesisⁱ	49	C → A: Prevents dimer formation. Does not alter ATP-binding. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000092328	1 – 222	Cell division ATP-binding protein FtsEAdd BLAST		222

Proteomic databases

EPDⁱ	P0A9R7
PaxDbⁱ	P0A9R7
PRIDEⁱ	P0A9R7

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:10048040). Forms a membrane-associated complex with FtsX (PubMed:10048040). Interacts with FtsZ, independently of FtsX, FtsA or ZipA (PubMed:17307852).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ftsZ	P0A9A6	2	EBI-550637,EBI-370963

With

Entry

#Exp.

IntAct

Notes

ftsZ

P0A9A6

2

EBI-550637,EBI-370963

Protein-protein interaction databases

BioGridⁱ	4260774, 393 interactors
Database of interacting proteins More...DIPⁱ	DIP-47843N
IntActⁱ	P0A9R7, 27 interactors
STRINGⁱ	316385.ECDH10B_3637

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0A9R7
SMRⁱ	P0A9R7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 222	ABC transporterPROSITE-ProRule annotationAdd BLAST		221

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4105CAK Bacteria COG2884 LUCA
InParanoidⁱ	P0A9R7
KEGG Orthology (KO) More...KOⁱ	K09812
OMAⁱ	DPDNSWQ
PhylomeDBⁱ	P0A9R7

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR005286 Cell_div_FtsE_ATP-bd IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR02673 FtsE, 1 hit
PROSITEⁱ	View protein in PROSITE PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0A9R7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIRFEHVSKA YLGGRQALQG VTFHMQPGEM AFLTGHSGAG KSTLLKLICG 
        60         70         80         90        100
IERPSAGKIW FSGHDITRLK NREVPFLRRQ IGMIFQDHHL LMDRTVYDNV 
       110        120        130        140        150
AIPLIIAGAS GDDIRRRVSA ALDKVGLLDK AKNFPIQLSG GEQQRVGIAR 
       160        170        180        190        200
AVVNKPAVLL ADEPTGNLDD ALSEGILRLF EEFNRVGVTV LMATHDINLI 
       210        220 
SRRSYRMLTL SDGHLHGGVG HE

Length:222

Mass (Da):24,439

Last modified:July 19, 2005 - v1

Checksum:ⁱ13CFCDECD8FE7590

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04398 Genomic DNA Translation: CAA27985.1 U00039 Genomic DNA Translation: AAB18438.1 U00096 Genomic DNA Translation: AAC76488.1 AP009048 Genomic DNA Translation: BAE77830.1
PIRⁱ	S03131 CEECFE
NCBI Reference Sequences More...RefSeqⁱ	NP_417920.1, NC_000913.3 WP_000617723.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC76488; AAC76488; b3463 BAE77830; BAE77830; BAE77830
GeneIDⁱ	947968
KEGGⁱ	ecj:JW3428 eco:b3463
PATRICⁱ	fig\|1411691.4.peg.3262

Protein	Similar proteins		Species	Score	Length
P0A9R7	Cell division ATP-binding protein FtsE		ECO57		222
Cell division ATP-binding protein FtsE		ECOL6		222
Cell division ATP-binding protein FtsE		SHIFL		222
Transporter subunit: ATP-binding component of ABC superfamily		Escherichia coli NCCP15648		222
Cell division protein FtsE		Escherichia coli O127:H6		222
+177

Protein	Similar proteins		Species	Score	Length
P0A9R7	Cell division ATP-binding protein FtsE		ECO57		222
Cell division ATP-binding protein FtsE		ECOL6		222
Cell division ATP-binding protein FtsE		SHIFL		222
Transporter subunit: ATP-binding component of ABC superfamily		Escherichia coli NCCP15648		222
Cell division protein FtsE		Escherichia coli O127:H6		222
+177

Protein	Similar proteins		Species	Score	Length
P0A9R7	Cell division ATP-binding protein FtsE		ECO57		222
Cell division ATP-binding protein FtsE		ECOL6		222
Cell division ATP-binding protein FtsE		SHIFL		222
Transporter subunit: ATP-binding component of ABC superfamily		Escherichia coli NCCP15648		222
Cell division protein FtsE		Escherichia coli O127:H6		222
+177

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04398 Genomic DNA Translation: CAA27985.1 U00039 Genomic DNA Translation: AAB18438.1 U00096 Genomic DNA Translation: AAC76488.1 AP009048 Genomic DNA Translation: BAE77830.1
PIRⁱ	S03131 CEECFE
NCBI Reference Sequences More...RefSeqⁱ	NP_417920.1, NC_000913.3 WP_000617723.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0A9R7
SMRⁱ	P0A9R7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260774, 393 interactors
Database of interacting proteins More...DIPⁱ	DIP-47843N
IntActⁱ	P0A9R7, 27 interactors
STRINGⁱ	316385.ECDH10B_3637

Protein family/group databases

TCDBⁱ	3.A.1.140.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.140.1 the atp-binding cassette (abc) superfamily

Proteomic databases

EPDⁱ	P0A9R7
PaxDbⁱ	P0A9R7
PRIDEⁱ	P0A9R7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76488; AAC76488; b3463 BAE77830; BAE77830; BAE77830
GeneIDⁱ	947968
KEGGⁱ	ecj:JW3428 eco:b3463
PATRICⁱ	fig\|1411691.4.peg.3262

Organism-specific databases

EchoBASEⁱ	EB0336
EcoGeneⁱ	EG10340 ftsE

Phylogenomic databases

eggNOGⁱ	ENOG4105CAK Bacteria COG2884 LUCA
InParanoidⁱ	P0A9R7
KEGG Orthology (KO) More...KOⁱ	K09812
OMAⁱ	DPDNSWQ
PhylomeDBⁱ	P0A9R7

Enzyme and pathway databases

BioCycⁱ	EcoCyc:FTSE-MONOMER

BioCycⁱ

EcoCyc:FTSE-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0A9R7

PROⁱ

PR:P0A9R7

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR005286 Cell_div_FtsE_ATP-bd IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR02673 FtsE, 1 hit
PROSITEⁱ	View protein in PROSITE PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FTSE_ECOLI
Accessionⁱ	P0A9R7Primary (citable) accession number: P0A9R7 Secondary accession number(s): P10115, Q2M7C6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	July 19, 2005
	Last modified:	March 28, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0A9R7 (FTSE_ECOLI)

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Cell division ATP-binding protein FtsE

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ