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Protein

Cell division ATP-binding protein FtsE

Gene

ftsE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 42ATP1 Publication8

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: EcoliWiki

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: EcoliWiki
  • response to antibiotic Source: EcoliWiki

Keywordsi

Biological processCell cycle, Cell division
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:FTSE-MONOMER

Protein family/group databases

TCDBi3.A.1.140.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division ATP-binding protein FtsECurated
Gene namesi
Name:ftsE
Ordered Locus Names:b3463, JW3428
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10340 ftsE

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Inactivation results in a filamented cellular morphology, but not in a temperature-sensitive phenotype.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41K → R: Does not bind ATP. 1 Publication1
Mutagenesisi49C → A: Prevents dimer formation. Does not alter ATP-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923281 – 222Cell division ATP-binding protein FtsEAdd BLAST222

Proteomic databases

EPDiP0A9R7
PaxDbiP0A9R7
PRIDEiP0A9R7

Interactioni

Subunit structurei

Homodimer (PubMed:10048040). Forms a membrane-associated complex with FtsX (PubMed:10048040). Interacts with FtsZ, independently of FtsX, FtsA or ZipA (PubMed:17307852).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ftsZP0A9A62EBI-550637,EBI-370963

Protein-protein interaction databases

BioGridi4260774, 393 interactors
DIPiDIP-47843N
IntActiP0A9R7, 27 interactors
STRINGi316385.ECDH10B_3637

Structurei

3D structure databases

ProteinModelPortaliP0A9R7
SMRiP0A9R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 222ABC transporterPROSITE-ProRule annotationAdd BLAST221

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CAK Bacteria
COG2884 LUCA
InParanoidiP0A9R7
KOiK09812
PhylomeDBiP0A9R7

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005286 Cell_div_FtsE_ATP-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02673 FtsE, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRFEHVSKA YLGGRQALQG VTFHMQPGEM AFLTGHSGAG KSTLLKLICG
60 70 80 90 100
IERPSAGKIW FSGHDITRLK NREVPFLRRQ IGMIFQDHHL LMDRTVYDNV
110 120 130 140 150
AIPLIIAGAS GDDIRRRVSA ALDKVGLLDK AKNFPIQLSG GEQQRVGIAR
160 170 180 190 200
AVVNKPAVLL ADEPTGNLDD ALSEGILRLF EEFNRVGVTV LMATHDINLI
210 220
SRRSYRMLTL SDGHLHGGVG HE
Length:222
Mass (Da):24,439
Last modified:July 19, 2005 - v1
Checksum:i13CFCDECD8FE7590
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04398 Genomic DNA Translation: CAA27985.1
U00039 Genomic DNA Translation: AAB18438.1
U00096 Genomic DNA Translation: AAC76488.1
AP009048 Genomic DNA Translation: BAE77830.1
PIRiS03131 CEECFE
RefSeqiNP_417920.1, NC_000913.3
WP_000617723.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76488; AAC76488; b3463
BAE77830; BAE77830; BAE77830
GeneIDi947968
KEGGiecj:JW3428
eco:b3463
PATRICifig|1411691.4.peg.3262

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04398 Genomic DNA Translation: CAA27985.1
U00039 Genomic DNA Translation: AAB18438.1
U00096 Genomic DNA Translation: AAC76488.1
AP009048 Genomic DNA Translation: BAE77830.1
PIRiS03131 CEECFE
RefSeqiNP_417920.1, NC_000913.3
WP_000617723.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0A9R7
SMRiP0A9R7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260774, 393 interactors
DIPiDIP-47843N
IntActiP0A9R7, 27 interactors
STRINGi316385.ECDH10B_3637

Protein family/group databases

TCDBi3.A.1.140.1 the atp-binding cassette (abc) superfamily

Proteomic databases

EPDiP0A9R7
PaxDbiP0A9R7
PRIDEiP0A9R7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76488; AAC76488; b3463
BAE77830; BAE77830; BAE77830
GeneIDi947968
KEGGiecj:JW3428
eco:b3463
PATRICifig|1411691.4.peg.3262

Organism-specific databases

EchoBASEiEB0336
EcoGeneiEG10340 ftsE

Phylogenomic databases

eggNOGiENOG4105CAK Bacteria
COG2884 LUCA
InParanoidiP0A9R7
KOiK09812
PhylomeDBiP0A9R7

Enzyme and pathway databases

BioCyciEcoCyc:FTSE-MONOMER

Miscellaneous databases

PROiPR:P0A9R7

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005286 Cell_div_FtsE_ATP-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02673 FtsE, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFTSE_ECOLI
AccessioniPrimary (citable) accession number: P0A9R7
Secondary accession number(s): P10115, Q2M7C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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