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Protein

2Fe-2S ferredoxin

Gene

fdx

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron-sulfur proteins.

Cofactori

[2Fe-2S] clusterNote: Binds 1 [2Fe-2S] cluster.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi42Iron-sulfur (2Fe-2S)1
Metal bindingi48Iron-sulfur (2Fe-2S)1
Metal bindingi51Iron-sulfur (2Fe-2S)1
Metal bindingi87Iron-sulfur (2Fe-2S)1

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: EcoCyc
  • electron transfer activity Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoCyc

Keywordsi

Biological processElectron transport, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:FERREDOXIN-MONOMER
MetaCyc:FERREDOXIN-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
2Fe-2S ferredoxin
Gene namesi
Name:fdx
Ordered Locus Names:b2525, JW2509
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11328 fdx

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002011682 – 1112Fe-2S ferredoxinAdd BLAST110

Proteomic databases

EPDiP0A9R4
PaxDbiP0A9R4
PRIDEiP0A9R4

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi4260584, 52 interactors
DIPiDIP-48512N
IntActiP0A9R4, 14 interactors
STRINGi316385.ECDH10B_2692

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A9R4
SMRiP0A9R4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9R4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 1042Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the adrenodoxin/putidaredoxin family.Curated

Phylogenomic databases

eggNOGiENOG4108ZIT Bacteria
COG0633 LUCA
HOGENOMiHOG000244519
InParanoidiP0A9R4
KOiK04755
PhylomeDBiP0A9R4

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR001055 Adrenodoxin
IPR018298 Adrenodoxin_Fe-S_BS
IPR012675 Beta-grasp_dom_sf
IPR011536 Fdx_isc
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PRINTSiPR00355 ADRENODOXIN
SUPFAMiSSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR02007 fdx_isc, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00814 ADX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKIVILPHQ DLCPDGAVLE ANSGETILDA ALRNGIEIEH ACEKSCACTT
60 70 80 90 100
CHCIVREGFD SLPESSEQED DMLDKAWGLE PESRLSCQAR VTDEDLVVEI
110
PRYTINHARE H
Length:111
Mass (Da):12,331
Last modified:January 23, 2007 - v2
Checksum:iF7B3240F950DC0E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8P → Y AA sequence (PubMed:4375562).Curated1
Sequence conflicti63P → Q in U01827 (PubMed:8300516).Curated1
Sequence conflicti68 – 69QE → HQ in U01827 (PubMed:8300516).Curated2
Sequence conflicti74D → N in U01827 (PubMed:8300516).Curated1
Sequence conflicti77W → R in U01827 (PubMed:8300516).Curated1
Sequence conflicti91 – 93VTD → SYH in U01827 (PubMed:8300516).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88654 Genomic DNA Translation: AAA23755.1
U05338 Genomic DNA Translation: AAD13474.1
U01827 Unassigned DNA No translation available.
U00096 Genomic DNA Translation: AAC75578.1
AP009048 Genomic DNA Translation: BAA16415.1
PIRiJC1110
RefSeqiNP_417020.1, NC_000913.3
WP_001124469.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75578; AAC75578; b2525
BAA16415; BAA16415; BAA16415
GeneIDi947160
KEGGiecj:JW2509
eco:b2525
PATRICifig|1411691.4.peg.4209

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88654 Genomic DNA Translation: AAA23755.1
U05338 Genomic DNA Translation: AAD13474.1
U01827 Unassigned DNA No translation available.
U00096 Genomic DNA Translation: AAC75578.1
AP009048 Genomic DNA Translation: BAA16415.1
PIRiJC1110
RefSeqiNP_417020.1, NC_000913.3
WP_001124469.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I7HX-ray1.70A/B/C1-111[»]
ProteinModelPortaliP0A9R4
SMRiP0A9R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260584, 52 interactors
DIPiDIP-48512N
IntActiP0A9R4, 14 interactors
STRINGi316385.ECDH10B_2692

Proteomic databases

EPDiP0A9R4
PaxDbiP0A9R4
PRIDEiP0A9R4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75578; AAC75578; b2525
BAA16415; BAA16415; BAA16415
GeneIDi947160
KEGGiecj:JW2509
eco:b2525
PATRICifig|1411691.4.peg.4209

Organism-specific databases

EchoBASEiEB1304
EcoGeneiEG11328 fdx

Phylogenomic databases

eggNOGiENOG4108ZIT Bacteria
COG0633 LUCA
HOGENOMiHOG000244519
InParanoidiP0A9R4
KOiK04755
PhylomeDBiP0A9R4

Enzyme and pathway databases

BioCyciEcoCyc:FERREDOXIN-MONOMER
MetaCyc:FERREDOXIN-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A9R4
PROiPR:P0A9R4

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR001055 Adrenodoxin
IPR018298 Adrenodoxin_Fe-S_BS
IPR012675 Beta-grasp_dom_sf
IPR011536 Fdx_isc
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PRINTSiPR00355 ADRENODOXIN
SUPFAMiSSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR02007 fdx_isc, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00814 ADX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFER_ECOLI
AccessioniPrimary (citable) accession number: P0A9R4
Secondary accession number(s): P25528
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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