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Protein

Aerobic respiration control protein ArcA

Gene

arcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes; It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi134 – 234OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST101

GO - Molecular functioni

  • bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding Source: CollecTF
  • bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding Source: CollecTF
  • DNA binding transcription factor activity Source: EcoCyc
  • identical protein binding Source: IntAct
  • phosphorelay response regulator activity Source: EcoCyc
  • transcription regulatory region sequence-specific DNA binding Source: CollecTF

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • phosphorelay signal transduction system Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciEcoCyc:ARCA-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aerobic respiration control protein ArcA
Alternative name(s):
Dye resistance protein
Gene namesi
Name:arcA
Synonyms:cpxC, dye, fexA, msp, seg, sfrA
Ordered Locus Names:b4401, JW4364
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10061 arcA

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • protein-DNA complex Source: CollecTF

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810081 – 238Aerobic respiration control protein ArcAAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by ArcB.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0A9Q1
PaxDbiP0A9Q1
PRIDEiP0A9Q1

2D gel databases

SWISS-2DPAGEiP0A9Q1

Expressioni

Gene expression databases

CollecTFiEXPREG_00000800

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259386, 13 interactors
DIPiDIP-36035N
IntActiP0A9Q1, 7 interactors
STRINGi316385.ECDH10B_4559

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Helixi13 – 24Combined sources12
Turni25 – 27Combined sources3
Beta strandi29 – 35Combined sources7
Helixi36 – 45Combined sources10
Beta strandi49 – 53Combined sources5
Beta strandi58 – 60Combined sources3
Helixi62 – 72Combined sources11
Beta strandi76 – 82Combined sources7
Helixi86 – 95Combined sources10
Beta strandi98 – 104Combined sources7
Helixi107 – 121Combined sources15

3D structure databases

ProteinModelPortaliP0A9Q1
SMRiP0A9Q1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9Q1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 118Response regulatoryPROSITE-ProRule annotationAdd BLAST114

Phylogenomic databases

eggNOGiENOG41065U4 Bacteria
COG0745 LUCA
HOGENOMiHOG000034819
InParanoidiP0A9Q1
KOiK07773
OMAiMHISWLR
PhylomeDBiP0A9Q1

Family and domain databases

CDDicd00156 REC, 1 hit
cd00383 trans_reg_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR001867 OmpR/PhoB-type_DNA-bd
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR001789 Sig_transdc_resp-reg_receiver
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00072 Response_reg, 1 hit
PF00486 Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SM00862 Trans_reg_C, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51755 OMPR_PHOB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTPHILIVE DELVTRNTLK SIFEAEGYDV FEATDGAEMH QILSEYDINL
60 70 80 90 100
VIMDINLPGK NGLLLARELR EQANVALMFL TGRDNEVDKI LGLEIGADDY
110 120 130 140 150
ITKPFNPREL TIRARNLLSR TMNLGTVSEE RRSVESYKFN GWELDINSRS
160 170 180 190 200
LIGPDGEQYK LPRSEFRAML HFCENPGKIQ SRAELLKKMT GRELKPHDRT
210 220 230
VDVTIRRIRK HFESTPDTPE IIATIHGEGY RFCGDLED
Length:238
Mass (Da):27,292
Last modified:July 21, 1986 - v1
Checksum:i9316CF4DE8EABDE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10044 Genomic DNA Translation: AAA23718.1
U14003 Genomic DNA Translation: AAA97297.1
U00096 Genomic DNA Translation: AAC77354.1
AP009048 Genomic DNA Translation: BAE78390.1
L34010 Genomic DNA Translation: AAA23476.1
PIRiA03561 JYECR
RefSeqiNP_418818.1, NC_000913.3
WP_001194358.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77354; AAC77354; b4401
BAE78390; BAE78390; BAE78390
GeneIDi948874
KEGGiecj:JW4364
eco:b4401
PATRICifig|1411691.4.peg.2283

Similar proteinsi

Entry informationi

Entry nameiARCA_ECOLI
AccessioniPrimary (citable) accession number: P0A9Q1
Secondary accession number(s): P03026, Q2M5R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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