UniProtKB - P0A9P1 (DLDH_ECOL6)
Protein
Dihydrolipoyl dehydrogenase
Gene
lpdA
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Functioni
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes.By similarity
Miscellaneous
The active site is a redox-active disulfide bond.By similarity
Catalytic activityi
- EC:1.8.1.4
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | FADBy similarity | 1 | |
Binding sitei | 117 | FAD; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 205 | NADBy similarity | 1 | |
Binding sitei | 238 | NAD; via amide nitrogenBy similarity | 1 | |
Binding sitei | 313 | FADBy similarity | 1 | |
Binding sitei | 321 | FAD; via amide nitrogenBy similarity | 1 | |
Active sitei | 445 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 45 | FADBy similarity | 10 | |
Nucleotide bindingi | 182 – 186 | NADBy similarity | 5 | |
Nucleotide bindingi | 270 – 273 | NADBy similarity | 4 |
GO - Molecular functioni
- dihydrolipoyl dehydrogenase activity Source: UniProtKB-EC
- electron transfer activity Source: InterPro
- flavin adenine dinucleotide binding Source: InterPro
GO - Biological processi
- cell redox homeostasis Source: InterPro
- glycolytic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glycolysis |
Ligand | FAD, Flavoprotein, NAD |
Names & Taxonomyi
Protein namesi | Recommended name: Dihydrolipoyl dehydrogenase (EC:1.8.1.4)Alternative name(s): Dihydrolipoamide dehydrogenase E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes Glycine cleavage system L protein |
Gene namesi | Name:lpdA Ordered Locus Names:c0145 |
Organismi | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) |
Taxonomic identifieri | 199310 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000068029 | 2 – 474 | Dihydrolipoyl dehydrogenaseAdd BLAST | 473 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 50 | Redox-activeBy similarity | ||
Modified residuei | 220 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Disulfide bondProteomic databases
PRIDEi | P0A9P1 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 199310.c0145 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | ENOG4107QN2 Bacteria COG1249 LUCA |
HOGENOMi | HOG000276708 |
KOi | K00382 |
OMAi | TMSEAVM |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188 FAD/NAD-bd_sf IPR023753 FAD/NAD-binding_dom IPR016156 FAD/NAD-linked_Rdtase_dimer_sf IPR006258 Lipoamide_DH IPR001100 Pyr_nuc-diS_OxRdtase IPR004099 Pyr_nucl-diS_OxRdtase_dimer IPR012999 Pyr_OxRdtase_I_AS |
Pfami | View protein in Pfam PF07992 Pyr_redox_2, 1 hit PF02852 Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350 Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905 SSF51905, 1 hit SSF55424 SSF55424, 1 hit |
TIGRFAMsi | TIGR01350 lipoamide_DH, 1 hit |
PROSITEi | View protein in PROSITE PS00076 PYRIDINE_REDOX_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0A9P1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTEIKTQVV VLGAGPAGYS AAFRCADLGL ETVIVERYNT LGGVCLNVGC
60 70 80 90 100
IPSKALLHVA KVIEEAKALA EHGIVFGEPK TDIDKIRTWK EKVINQLTGG
110 120 130 140 150
LAGMAKGRKV KVVNGLGKFT GANTLEVEGE NGKTVINFDN AIIAAGSRPI
160 170 180 190 200
QLPFIPHEDP RIWDSTDALE LKEVPERLLV MGGGIIGLEM GTVYHALGSQ
210 220 230 240 250
IDVVEMFDQV IPAADKDIVK VFTKRISKKF NLMLETKVTA VEAKEDGIYV
260 270 280 290 300
TMEGKKAPAE PQRYDAVLVA IGRVPNGKNL DAGKAGVEVD DRGFIRVDKQ
310 320 330 340 350
LRTNVPHIFA IGDIVGQPML AHKGVHEGHV AAEVIAGKKH YFDPKVIPSI
360 370 380 390 400
AYTEPEVAWV GLTEKEAKEK GISYETATFP WAASGRAIAS DCADGMTKLI
410 420 430 440 450
FDKESHRVIG GAIVGTNGGE LLGEIGLAIE MGCDAEDIAL TIHAHPTLHE
460 470
SVGLAAEVFE GSITDLPNPK AKKK
Sequence cautioni
The sequence AAN78639 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN78639.1 Different initiation. |
RefSeqi | WP_000102485.1, NC_004431.1 |
Genome annotation databases
EnsemblBacteriai | AAN78639; AAN78639; c0145 |
KEGGi | ecc:c0145 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN78639.1 Different initiation. |
RefSeqi | WP_000102485.1, NC_004431.1 |
3D structure databases
SMRi | P0A9P1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 199310.c0145 |
Proteomic databases
PRIDEi | P0A9P1 |
Genome annotation databases
EnsemblBacteriai | AAN78639; AAN78639; c0145 |
KEGGi | ecc:c0145 |
Phylogenomic databases
eggNOGi | ENOG4107QN2 Bacteria COG1249 LUCA |
HOGENOMi | HOG000276708 |
KOi | K00382 |
OMAi | TMSEAVM |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188 FAD/NAD-bd_sf IPR023753 FAD/NAD-binding_dom IPR016156 FAD/NAD-linked_Rdtase_dimer_sf IPR006258 Lipoamide_DH IPR001100 Pyr_nuc-diS_OxRdtase IPR004099 Pyr_nucl-diS_OxRdtase_dimer IPR012999 Pyr_OxRdtase_I_AS |
Pfami | View protein in Pfam PF07992 Pyr_redox_2, 1 hit PF02852 Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350 Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905 SSF51905, 1 hit SSF55424 SSF55424, 1 hit |
TIGRFAMsi | TIGR01350 lipoamide_DH, 1 hit |
PROSITEi | View protein in PROSITE PS00076 PYRIDINE_REDOX_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DLDH_ECOL6 | |
Accessioni | P0A9P1Primary (citable) accession number: P0A9P1 Secondary accession number(s): P00391 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | November 13, 2019 | |
This is version 97 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteomeDocuments
- SIMILARITY comments
Index of protein domains and families