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Protein

Citrate lyase subunit beta

Gene

citE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Represents a citryl-ACP lyase.By similarity

Catalytic activityi

Citrate = acetate + oxaloacetate.
(3S)-citryl-CoA = acetyl-CoA + oxaloacetate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76SubstrateBy similarity1
Metal bindingi139MagnesiumBy similarity1
Binding sitei139SubstrateBy similarity1
Metal bindingi166MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:CITRYLY-MONOMER
MetaCyc:CITRYLY-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate lyase subunit beta (EC:4.1.3.6)
Short name:
Citrase beta chain
Alternative name(s):
Citrate (pro-3S)-lyase subunit beta
Citryl-CoA lyase subunit (EC:4.1.3.34)
Gene namesi
Name:citE
Synonyms:ybdW
Ordered Locus Names:b0616, JW0608
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13542 citE

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897571 – 302Citrate lyase subunit betaAdd BLAST302

Proteomic databases

PaxDbiP0A9I1
PRIDEiP0A9I1

Expressioni

Inductioni

Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

Interactioni

Subunit structurei

Oligomer with a subunit composition of (alpha,beta, gamma)6.By similarity

Protein-protein interaction databases

BioGridi4261999, 12 interactors
DIPiDIP-9285N
IntActiP0A9I1, 9 interactors
STRINGi316385.ECDH10B_0684

Structurei

3D structure databases

ProteinModelPortaliP0A9I1
SMRiP0A9I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CI0 Bacteria
COG2301 LUCA
HOGENOMiHOG000242282
InParanoidiP0A9I1
KOiK01644
OMAiAGKTVIH
PhylomeDBiP0A9I1

Family and domain databases

InterProiView protein in InterPro
IPR005000 Aldolase/citrate-lyase_domain
IPR011206 Citrate_lyase_beta/mcl1/mcl2
IPR006475 Citrate_lyase_beta_bac
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PfamiView protein in Pfam
PF03328 HpcH_HpaI, 1 hit
PIRSFiPIRSF015582 Cit_lyase_B, 1 hit
SUPFAMiSSF51621 SSF51621, 1 hit
TIGRFAMsiTIGR01588 citE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISASLQQRK TRTRRSMLFV PGANAAMVSN SFIYPADALM FDLEDSVALR
60 70 80 90 100
EKDTARRMVY HALQHPLYRD IETIVRVNAL DSEWGVNDLE AVVRGGADVV
110 120 130 140 150
RLPKTDTAQD VLDIEKEILR IEKACGREPG STGLLAAIES PLGITRAVEI
160 170 180 190 200
AHASERLIGI ALGAEDYVRN LRTERSPEGT ELLFARCSIL QAARSAGIQA
210 220 230 240 250
FDTVYSDANN EAGFLQEAAH IKQLGFDGKS LINPRQIDLL HNLYAPTQKE
260 270 280 290 300
VDHARRVVEA AEAAAREGLG VVSLNGKMVD GPVIDRARLV LSRAELSGIR

EE
Length:302
Mass (Da):33,110
Last modified:July 19, 2005 - v1
Checksum:i204E8CCD40A2A52E
GO

Sequence cautioni

The sequence AAB40816 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150 – 156IAHASER → SLTLPRL in AAC28948 (Ref. 5) Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40816.1 Different initiation.
U00096 Genomic DNA Translation: AAC73717.2
AP009048 Genomic DNA Translation: BAA35252.1
U46667 Genomic DNA Translation: AAC28948.1
PIRiF64795
RefSeqiNP_415149.4, NC_000913.3
WP_000622357.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73717; AAC73717; b0616
BAA35252; BAA35252; BAA35252
GeneIDi945406
KEGGiecj:JW0608
eco:b0616
PATRICifig|1411691.4.peg.1652

Similar proteinsi

Entry informationi

Entry nameiCITE_ECOLI
AccessioniPrimary (citable) accession number: P0A9I1
Secondary accession number(s): O54335, P77770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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