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Protein

Inducible lysine decarboxylase

Gene

cadA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in pH homeostasis by consuming protons and neutralizing the acidic by-products of carbohydrate fermentation.

Catalytic activityi

L-lysine = cadaverine + CO2.

Cofactori

GO - Molecular functioni

  • guanosine tetraphosphate binding Source: EcoCyc
  • identical protein binding Source: IntAct
  • lysine decarboxylase activity Source: EcoCyc

GO - Biological processi

  • lysine catabolic process Source: EcoliWiki

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:LYSDECARBOX-MONOMER
MetaCyc:LYSDECARBOX-MONOMER
BRENDAi4.1.1.18 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Inducible lysine decarboxylase (EC:4.1.1.18)
Short name:
LDC
Gene namesi
Name:cadA
Synonyms:ldcI
Ordered Locus Names:b4131, JW4092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10131 cadA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011381 – 715Inducible lysine decarboxylaseAdd BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei367N6-(pyridoxal phosphate)lysine1

Proteomic databases

PaxDbiP0A9H3
PRIDEiP0A9H3

Expressioni

Inductioni

At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC.1 Publication

Interactioni

Subunit structurei

Homodecamer at pH 7.0/low ionic strength and dimer at pH 8.0/high ionic strength. Interacts with RavA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4260777, 2 interactors
DIPiDIP-35646N
IntActiP0A9H3, 20 interactors
MINTiP0A9H3
STRINGi316385.ECDH10B_4324

Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi13 – 28Combined sources16
Beta strandi32 – 34Combined sources3
Helixi39 – 48Combined sources10
Beta strandi52 – 58Combined sources7
Helixi59 – 73Combined sources15
Beta strandi78 – 82Combined sources5
Helixi91 – 93Combined sources3
Beta strandi99 – 103Combined sources5
Helixi110 – 128Combined sources19
Helixi131 – 142Combined sources12
Turni151 – 155Combined sources5
Helixi156 – 160Combined sources5
Helixi162 – 171Combined sources10
Helixi173 – 177Combined sources5
Helixi185 – 187Combined sources3
Turni190 – 193Combined sources4
Helixi196 – 208Combined sources13
Beta strandi211 – 218Combined sources8
Helixi219 – 231Combined sources13
Beta strandi237 – 243Combined sources7
Helixi246 – 254Combined sources9
Beta strandi258 – 262Combined sources5
Helixi277 – 280Combined sources4
Helixi282 – 291Combined sources10
Beta strandi299 – 306Combined sources8
Beta strandi310 – 313Combined sources4
Helixi315 – 321Combined sources7
Beta strandi325 – 330Combined sources6
Helixi337 – 339Combined sources3
Helixi341 – 343Combined sources3
Beta strandi350 – 352Combined sources3
Beta strandi358 – 363Combined sources6
Beta strandi376 – 382Combined sources7
Helixi386 – 395Combined sources10
Helixi403 – 416Combined sources14
Helixi418 – 445Combined sources28
Beta strandi446 – 448Combined sources3
Beta strandi452 – 455Combined sources4
Beta strandi481 – 486Combined sources6
Beta strandi490 – 494Combined sources5
Helixi511 – 520Combined sources10
Beta strandi526 – 529Combined sources4
Beta strandi532 – 536Combined sources5
Helixi543 – 561Combined sources19
Helixi566 – 569Combined sources4
Helixi571 – 576Combined sources6
Helixi578 – 581Combined sources4
Helixi586 – 599Combined sources14
Helixi602 – 609Combined sources8
Beta strandi615 – 618Combined sources4
Helixi620 – 628Combined sources9
Beta strandi632 – 636Combined sources5
Helixi637 – 639Combined sources3
Beta strandi644 – 647Combined sources4
Beta strandi649 – 652Combined sources4
Helixi670 – 682Combined sources13
Beta strandi692 – 694Combined sources3
Beta strandi704 – 709Combined sources6

3D structure databases

ProteinModelPortaliP0A9H3
SMRiP0A9H3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9H3

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
HOGENOMiHOG000164394
InParanoidiP0A9H3
KOiK01582
OMAiTGLDDLH
PhylomeDBiP0A9H3

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005308 OKR_de-COase_N
IPR011193 Orn/lys/arg_de-COase
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR008286 Prn/Lys/Arg_de-COase_C
IPR036633 Prn/Lys/Arg_de-COase_C_sf
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
PF03709 OKR_DC_1_N, 1 hit
PIRSFiPIRSF009393 Orn_decarb, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
SSF55904 SSF55904, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVIAILNHM GVYFKEEPIR ELHRALERLN FQIVYPNDRD DLLKLIENNA
60 70 80 90 100
RLCGVIFDWD KYNLELCEEI SKMNENLPLY AFANTYSTLD VSLNDLRLQI
110 120 130 140 150
SFFEYALGAA EDIANKIKQT TDEYINTILP PLTKALFKYV REGKYTFCTP
160 170 180 190 200
GHMGGTAFQK SPVGSLFYDF FGPNTMKSDI SISVSELGSL LDHSGPHKEA
210 220 230 240 250
EQYIARVFNA DRSYMVTNGT STANKIVGMY SAPAGSTILI DRNCHKSLTH
260 270 280 290 300
LMMMSDVTPI YFRPTRNAYG ILGGIPQSEF QHATIAKRVK ETPNATWPVH
310 320 330 340 350
AVITNSTYDG LLYNTDFIKK TLDVKSIHFD SAWVPYTNFS PIYEGKCGMS
360 370 380 390 400
GGRVEGKVIY ETQSTHKLLA AFSQASMIHV KGDVNEETFN EAYMMHTTTS
410 420 430 440 450
PHYGIVASTE TAAAMMKGNA GKRLINGSIE RAIKFRKEIK RLRTESDGWF
460 470 480 490 500
FDVWQPDHID TTECWPLRSD STWHGFKNID NEHMYLDPIK VTLLTPGMEK
510 520 530 540 550
DGTMSDFGIP ASIVAKYLDE HGIVVEKTGP YNLLFLFSIG IDKTKALSLL
560 570 580 590 600
RALTDFKRAF DLNLRVKNML PSLYREDPEF YENMRIQELA QNIHKLIVHH
610 620 630 640 650
NLPDLMYRAF EVLPTMVMTP YAAFQKELHG MTEEVYLDEM VGRINANMIL
660 670 680 690 700
PYPPGVPLVM PGEMITEESR PVLEFLQMLC EIGAHYPGFE TDIHGAYRQA
710
DGRYTVKVLK EESKK
Length:715
Mass (Da):81,260
Last modified:July 19, 2005 - v1
Checksum:iB9776622A0AE0190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76411 Genomic DNA Translation: AAA23536.1
U14003 Genomic DNA Translation: AAA97031.1
U00096 Genomic DNA Translation: AAC77092.1
AP009048 Genomic DNA Translation: BAE78134.1
M67452 Genomic DNA Translation: AAA23533.1
PIRiB41842
RefSeqiNP_418555.1, NC_000913.3
WP_001295383.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77092; AAC77092; b4131
BAE78134; BAE78134; BAE78134
GeneIDi948643
KEGGiecj:JW4092
eco:b4131
PATRICifig|1411691.4.peg.2568

Similar proteinsi

Entry informationi

Entry nameiLDCI_ECOLI
AccessioniPrimary (citable) accession number: P0A9H3
Secondary accession number(s): P23892, Q2M6H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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