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Protein

Inducible lysine decarboxylase

Gene

cadA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in pH homeostasis by consuming protons and neutralizing the acidic by-products of carbohydrate fermentation.

Catalytic activityi

L-lysine = cadaverine + CO2.

Cofactori

GO - Molecular functioni

  • guanosine tetraphosphate binding Source: EcoCyc
  • identical protein binding Source: IntAct
  • lysine decarboxylase activity Source: EcoCyc

GO - Biological processi

  • lysine catabolic process Source: EcoliWiki

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:LYSDECARBOX-MONOMER
MetaCyc:LYSDECARBOX-MONOMER
BRENDAi4.1.1.18 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Inducible lysine decarboxylase (EC:4.1.1.18)
Short name:
LDC
Gene namesi
Name:cadA
Synonyms:ldcI
Ordered Locus Names:b4131, JW4092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10131 cadA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011381 – 715Inducible lysine decarboxylaseAdd BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei367N6-(pyridoxal phosphate)lysine1

Proteomic databases

PaxDbiP0A9H3
PRIDEiP0A9H3

Expressioni

Inductioni

At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC.1 Publication

Interactioni

Subunit structurei

Homodecamer at pH 7.0/low ionic strength and dimer at pH 8.0/high ionic strength. Interacts with RavA.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4260777, 2 interactors
DIPiDIP-35646N
IntActiP0A9H3, 20 interactors
MINTiP0A9H3
STRINGi316385.ECDH10B_4324

Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A9H3
SMRiP0A9H3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9H3

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
HOGENOMiHOG000164394
InParanoidiP0A9H3
KOiK01582
PhylomeDBiP0A9H3

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005308 OKR_de-COase_N
IPR011193 Orn/lys/arg_de-COase
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR008286 Prn/Lys/Arg_de-COase_C
IPR036633 Prn/Lys/Arg_de-COase_C_sf
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
PF03709 OKR_DC_1_N, 1 hit
PIRSFiPIRSF009393 Orn_decarb, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
SSF55904 SSF55904, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9H3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVIAILNHM GVYFKEEPIR ELHRALERLN FQIVYPNDRD DLLKLIENNA
60 70 80 90 100
RLCGVIFDWD KYNLELCEEI SKMNENLPLY AFANTYSTLD VSLNDLRLQI
110 120 130 140 150
SFFEYALGAA EDIANKIKQT TDEYINTILP PLTKALFKYV REGKYTFCTP
160 170 180 190 200
GHMGGTAFQK SPVGSLFYDF FGPNTMKSDI SISVSELGSL LDHSGPHKEA
210 220 230 240 250
EQYIARVFNA DRSYMVTNGT STANKIVGMY SAPAGSTILI DRNCHKSLTH
260 270 280 290 300
LMMMSDVTPI YFRPTRNAYG ILGGIPQSEF QHATIAKRVK ETPNATWPVH
310 320 330 340 350
AVITNSTYDG LLYNTDFIKK TLDVKSIHFD SAWVPYTNFS PIYEGKCGMS
360 370 380 390 400
GGRVEGKVIY ETQSTHKLLA AFSQASMIHV KGDVNEETFN EAYMMHTTTS
410 420 430 440 450
PHYGIVASTE TAAAMMKGNA GKRLINGSIE RAIKFRKEIK RLRTESDGWF
460 470 480 490 500
FDVWQPDHID TTECWPLRSD STWHGFKNID NEHMYLDPIK VTLLTPGMEK
510 520 530 540 550
DGTMSDFGIP ASIVAKYLDE HGIVVEKTGP YNLLFLFSIG IDKTKALSLL
560 570 580 590 600
RALTDFKRAF DLNLRVKNML PSLYREDPEF YENMRIQELA QNIHKLIVHH
610 620 630 640 650
NLPDLMYRAF EVLPTMVMTP YAAFQKELHG MTEEVYLDEM VGRINANMIL
660 670 680 690 700
PYPPGVPLVM PGEMITEESR PVLEFLQMLC EIGAHYPGFE TDIHGAYRQA
710
DGRYTVKVLK EESKK
Length:715
Mass (Da):81,260
Last modified:July 19, 2005 - v1
Checksum:iB9776622A0AE0190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76411 Genomic DNA Translation: AAA23536.1
U14003 Genomic DNA Translation: AAA97031.1
U00096 Genomic DNA Translation: AAC77092.1
AP009048 Genomic DNA Translation: BAE78134.1
M67452 Genomic DNA Translation: AAA23533.1
PIRiB41842
RefSeqiNP_418555.1, NC_000913.3
WP_001295383.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77092; AAC77092; b4131
BAE78134; BAE78134; BAE78134
GeneIDi948643
KEGGiecj:JW4092
eco:b4131
PATRICifig|1411691.4.peg.2568

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76411 Genomic DNA Translation: AAA23536.1
U14003 Genomic DNA Translation: AAA97031.1
U00096 Genomic DNA Translation: AAC77092.1
AP009048 Genomic DNA Translation: BAE78134.1
M67452 Genomic DNA Translation: AAA23533.1
PIRiB41842
RefSeqiNP_418555.1, NC_000913.3
WP_001295383.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N75X-ray2.00A/B/C/D/E1-715[»]
3Q16X-ray4.10A/B/C/D/E1-715[»]
4UPBelectron microscopy11.00A/B1-715[»]
4UPFelectron microscopy7.50A1-715[»]
5FKXelectron microscopy6.10A1-711[»]
5FL2electron microscopy6.20A1-711[»]
ProteinModelPortaliP0A9H3
SMRiP0A9H3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260777, 2 interactors
DIPiDIP-35646N
IntActiP0A9H3, 20 interactors
MINTiP0A9H3
STRINGi316385.ECDH10B_4324

Proteomic databases

PaxDbiP0A9H3
PRIDEiP0A9H3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77092; AAC77092; b4131
BAE78134; BAE78134; BAE78134
GeneIDi948643
KEGGiecj:JW4092
eco:b4131
PATRICifig|1411691.4.peg.2568

Organism-specific databases

EchoBASEiEB0129
EcoGeneiEG10131 cadA

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
HOGENOMiHOG000164394
InParanoidiP0A9H3
KOiK01582
PhylomeDBiP0A9H3

Enzyme and pathway databases

BioCyciEcoCyc:LYSDECARBOX-MONOMER
MetaCyc:LYSDECARBOX-MONOMER
BRENDAi4.1.1.18 2026

Miscellaneous databases

EvolutionaryTraceiP0A9H3
PROiPR:P0A9H3

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005308 OKR_de-COase_N
IPR011193 Orn/lys/arg_de-COase
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR008286 Prn/Lys/Arg_de-COase_C
IPR036633 Prn/Lys/Arg_de-COase_C_sf
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
PF03709 OKR_DC_1_N, 1 hit
PIRSFiPIRSF009393 Orn_decarb, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
SSF55904 SSF55904, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLDCI_ECOLI
AccessioniPrimary (citable) accession number: P0A9H3
Secondary accession number(s): P23892, Q2M6H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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