nhaR

Protein namesⁱ	Recommended name: Transcriptional activator protein NhaR Alternative name(s): Na(+)/H(+) antiporter regulatory protein
Gene namesⁱ	Name:nhaR Synonyms:antO Ordered Locus Names:b0020, JW0019
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11078 nhaR

EcoGeneⁱ

EG11078 nhaR

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	134	E → A in nhaR1; increases the transcription of NhaA.		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000105689	1 – 301	Transcriptional activator protein NhaRAdd BLAST		301

Proteomic databases

PaxDbⁱ	P0A9G2
PRIDEⁱ	P0A9G2

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4259724, 3 interactors
IntActⁱ	P0A9G2, 2 interactors
STRINGⁱ	316385.ECDH10B_0021

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0A9G2
SMRⁱ	P0A9G2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 63	HTH lysR-typePROSITE-ProRule annotationAdd BLAST		58

Phylogenomic databases

eggNOGⁱ	ENOG41063Z6 Bacteria COG0583 LUCA
HOGENOMⁱ	HOG000233515
InParanoidⁱ	P0A9G2
KEGG Orthology (KO) More...KOⁱ	K03717
OMAⁱ	WLNYHHL
PhylomeDBⁱ	P0A9G2

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR005119 LysR_subst-bd IPR000847 Tscrpt_reg_HTH_LysR IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00126 HTH_1, 1 hit PF03466 LysR_substrate, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50931 HTH_LYSR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0A9G2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSMSHINYNH LYYFWHVYKE GSVVGAAEAL YLTPQTITGQ IRALEERLQG 
        60         70         80         90        100
KLFKRKGRGL EPSELGELVY RYADKMFTLS QEMLDIVNYR KESNLLFDVG 
       110        120        130        140        150
VADALSKRLV SSVLNAAVVE GEPIHLRCFE STHEMLLEQL SQHKLDMIIS 
       160        170        180        190        200
DCPIDSTQQE GLFSVRIGEC GVSFWCTNPP PEKPFPACLE ERRLLIPGRR 
       210        220        230        240        250
SMLGRKLLNW FNSQGLNVEI LGEFDDAALM KAFGAMHNAI FVAPTLYAYD 
       260        270        280        290        300
FYADKTVVEI GRVENVMEEY HAIFAERMIQ HPAVQRICNT DYSALFSPAV 

R

Length:301

Mass (Da):34,284

Last modified:July 19, 2005 - v1

Checksum:ⁱE81FAFC4FC4FD2F1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	46 – 47	ER → DA (PubMed:2429258).Curated	2
Sequence conflictⁱ	46 – 47	ER → DA (Ref. 2) Curated	2
Sequence conflictⁱ	46 – 47	ER → DA (PubMed:1630901).Curated	2
Sequence conflictⁱ	50	G → A (PubMed:2429258).Curated	1
Sequence conflictⁱ	50	G → A (Ref. 2) Curated	1
Sequence conflictⁱ	50	G → A (PubMed:1630901).Curated	1
Sequence conflictⁱ	58 – 65	RGLEPSEL → TWSRTQRA (PubMed:2429258).Curated	8
Sequence conflictⁱ	58 – 65	RGLEPSEL → TWSRTQRA (PubMed:1630901).Curated	8
Sequence conflictⁱ	146	D → E (PubMed:2429258).Curated	1
Sequence conflictⁱ	146	D → E (Ref. 2) Curated	1
Sequence conflictⁱ	146	D → E (PubMed:1630901).Curated	1
Sequence conflictⁱ	233 – 301	FGAMH…SPAVR → WLQVLLVAMQMQSSLPQRFM HMTFMPIKLS (PubMed:2429258).CuratedAdd BLAST	69
Sequence conflictⁱ	233 – 301	FGAMH…SPAVR → WLQVLLVAMQMQSSLPQRFM HMTFMPIKLS (PubMed:1630901).CuratedAdd BLAST	69

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04382 Genomic DNA Translation: CAA27969.1 L24072 Genomic DNA Translation: AAA24221.1 U00096 Genomic DNA Translation: AAC73131.1 AP009048 Genomic DNA Translation: BAE76032.1
NCBI Reference Sequences More...RefSeqⁱ	NP_414561.1, NC_000913.3 WP_000062890.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73131; AAC73131; b0020 BAE76032; BAE76032; BAE76032
GeneIDⁱ	944757
KEGGⁱ	ecj:JW0019 eco:b0020
PATRICⁱ	fig\|511145.12.peg.17

Protein	Similar proteins		Species	Score	Length
P0A9G2	Transcriptional activator protein NhaR		SHIFL		301
Regulator		uncultured bacterium		301
Transcriptional activator of nhaA		ECOLX		301
Transcriptional activator protein NhaR		SHIBO		301
DNA-binding transcriptional activator		ECOCB		301
+27

Protein	Similar proteins		Species	Score	Length
P0A9G2	Transcriptional activator protein NhaR		SHIFL		301
Regulator		uncultured bacterium		301
Transcriptional activator of nhaA		ECOLX		301
Transcriptional activator protein NhaR		SHIBO		301
DNA-binding transcriptional activator		ECOCB		301
+581

Protein	Similar proteins		Species	Score	Length
P0A9G2	Transcriptional activator protein NhaR		SHIFL		301
Regulator		uncultured bacterium		301
Transcriptional activator of nhaA		ECOLX		301
Transcriptional activator protein NhaR		SHIBO		301
DNA-binding transcriptional activator		ECOCB		301
+1060

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04382 Genomic DNA Translation: CAA27969.1 L24072 Genomic DNA Translation: AAA24221.1 U00096 Genomic DNA Translation: AAC73131.1 AP009048 Genomic DNA Translation: BAE76032.1
NCBI Reference Sequences More...RefSeqⁱ	NP_414561.1, NC_000913.3 WP_000062890.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0A9G2
SMRⁱ	P0A9G2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4259724, 3 interactors
IntActⁱ	P0A9G2, 2 interactors
STRINGⁱ	316385.ECDH10B_0021

Proteomic databases

PaxDbⁱ	P0A9G2
PRIDEⁱ	P0A9G2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC73131; AAC73131; b0020 BAE76032; BAE76032; BAE76032
GeneIDⁱ	944757
KEGGⁱ	ecj:JW0019 eco:b0020
PATRICⁱ	fig\|511145.12.peg.17

Organism-specific databases

EchoBASEⁱ	EB1070
EcoGeneⁱ	EG11078 nhaR

Phylogenomic databases

eggNOGⁱ	ENOG41063Z6 Bacteria COG0583 LUCA
HOGENOMⁱ	HOG000233515
InParanoidⁱ	P0A9G2
KEGG Orthology (KO) More...KOⁱ	K03717
OMAⁱ	WLNYHHL
PhylomeDBⁱ	P0A9G2

Enzyme and pathway databases

BioCycⁱ	EcoCyc:PD00474

BioCycⁱ

EcoCyc:PD00474

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0A9G2

PROⁱ

PR:P0A9G2

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR005119 LysR_subst-bd IPR000847 Tscrpt_reg_HTH_LysR IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00126 HTH_1, 1 hit PF03466 LysR_substrate, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50931 HTH_LYSR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NHAR_ECOLI
Accessionⁱ	P0A9G2Primary (citable) accession number: P0A9G2 Secondary accession number(s): P10087 , P75619, Q2MCH4, Q47409, Q83SR2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	July 19, 2005
	Last modified:	March 28, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0A9G2 (NHAR_ECOLI)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcriptional activator protein NhaR

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ