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Protein

Transcriptional activator protein NhaR

Gene

nhaR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the positive regulation of NhaA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi23 – 42H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • positive regulation of DNA-templated transcription, initiation Source: EcoCyc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00474

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein NhaR
Alternative name(s):
Na(+)/H(+) antiporter regulatory protein
Gene namesi
Name:nhaR
Synonyms:antO
Ordered Locus Names:b0020, JW0019
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11078 nhaR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi134E → A in nhaR1; increases the transcription of NhaA. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056891 – 301Transcriptional activator protein NhaRAdd BLAST301

Proteomic databases

PaxDbiP0A9G2
PRIDEiP0A9G2

Interactioni

Protein-protein interaction databases

BioGridi4259724, 3 interactors
IntActiP0A9G2, 2 interactors
STRINGi316385.ECDH10B_0021

Structurei

3D structure databases

ProteinModelPortaliP0A9G2
SMRiP0A9G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 63HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG41063Z6 Bacteria
COG0583 LUCA
HOGENOMiHOG000233515
InParanoidiP0A9G2
KOiK03717
OMAiWLNYHHL
PhylomeDBiP0A9G2

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSHINYNH LYYFWHVYKE GSVVGAAEAL YLTPQTITGQ IRALEERLQG
60 70 80 90 100
KLFKRKGRGL EPSELGELVY RYADKMFTLS QEMLDIVNYR KESNLLFDVG
110 120 130 140 150
VADALSKRLV SSVLNAAVVE GEPIHLRCFE STHEMLLEQL SQHKLDMIIS
160 170 180 190 200
DCPIDSTQQE GLFSVRIGEC GVSFWCTNPP PEKPFPACLE ERRLLIPGRR
210 220 230 240 250
SMLGRKLLNW FNSQGLNVEI LGEFDDAALM KAFGAMHNAI FVAPTLYAYD
260 270 280 290 300
FYADKTVVEI GRVENVMEEY HAIFAERMIQ HPAVQRICNT DYSALFSPAV

R
Length:301
Mass (Da):34,284
Last modified:July 19, 2005 - v1
Checksum:iE81FAFC4FC4FD2F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 47ER → DA (PubMed:2429258).Curated2
Sequence conflicti46 – 47ER → DA (Ref. 2) Curated2
Sequence conflicti46 – 47ER → DA (PubMed:1630901).Curated2
Sequence conflicti50G → A (PubMed:2429258).Curated1
Sequence conflicti50G → A (Ref. 2) Curated1
Sequence conflicti50G → A (PubMed:1630901).Curated1
Sequence conflicti58 – 65RGLEPSEL → TWSRTQRA (PubMed:2429258).Curated8
Sequence conflicti58 – 65RGLEPSEL → TWSRTQRA (PubMed:1630901).Curated8
Sequence conflicti146D → E (PubMed:2429258).Curated1
Sequence conflicti146D → E (Ref. 2) Curated1
Sequence conflicti146D → E (PubMed:1630901).Curated1
Sequence conflicti233 – 301FGAMH…SPAVR → WLQVLLVAMQMQSSLPQRFM HMTFMPIKLS (PubMed:2429258).CuratedAdd BLAST69
Sequence conflicti233 – 301FGAMH…SPAVR → WLQVLLVAMQMQSSLPQRFM HMTFMPIKLS (PubMed:1630901).CuratedAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04382 Genomic DNA Translation: CAA27969.1
L24072 Genomic DNA Translation: AAA24221.1
U00096 Genomic DNA Translation: AAC73131.1
AP009048 Genomic DNA Translation: BAE76032.1
RefSeqiNP_414561.1, NC_000913.3
WP_000062890.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73131; AAC73131; b0020
BAE76032; BAE76032; BAE76032
GeneIDi944757
KEGGiecj:JW0019
eco:b0020
PATRICifig|511145.12.peg.17

Similar proteinsi

Entry informationi

Entry nameiNHAR_ECOLI
AccessioniPrimary (citable) accession number: P0A9G2
Secondary accession number(s): P10087
, P75619, Q2MCH4, Q47409, Q83SR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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