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Entry version 123 (13 Nov 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Arabinose operon regulatory protein

Gene

araC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose (PubMed:4362626, PubMed:328165, PubMed:6251457, PubMed:2962192, PubMed:6319708, PubMed:2231717, PubMed:1447222). Functions both as a positive and a negative regulator (PubMed:328165, PubMed:6251457). In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters (PubMed:4362626, PubMed:328165, PubMed:6251457, PubMed:2962192, PubMed:6319708, PubMed:2231717, PubMed:1447222). In the absence of arabinose, negatively regulates the araBAD operon (PubMed:6251457). Represses its own transcription (PubMed:328165). Acts by binding directly to DNA (PubMed:4943786, PubMed:6251457, PubMed:2962192, PubMed:2531226, PubMed:1447222).9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Arabinose converts the repressor form of AraC to the activator form to regulate the araBAD promoter (PubMed:2962192, PubMed:3279415). In the absence of arabinose, AraC binds to the araO2 and araI1 half-sites in the promoter region of the araBAD operon, leading to the formation of a DNA loop that blocks access of RNA polymerase to the promoter. In the presence of arabinose and the cyclic AMP receptor protein (CRP), it binds to the adjacent half-sites araI1 and araI2, leading to the binding of RNA polymerase to the promoter region and transcription of the araBAD operon (PubMed:2962192, PubMed:3279415). AraI1 acts as a switch mechanism allowing both the repressor and the activator forms of AraC protein to regulate the araBAD promoter (PubMed:2962192, PubMed:3279415). Inhibited by D-fucose, which binds competitively to the same site on the protein (PubMed:9367758).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei8Arabinose; via carbonyl oxygen1 Publication1 Publication1
Binding sitei24Arabinose1 Publication1 Publication1
Binding sitei38Arabinose1 Publication1 Publication1
Binding sitei82Arabinose1 Publication1 Publication1
Binding sitei93Arabinose1 Publication1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi198 – 219H-T-H motifPROSITE-ProRule annotation1 PublicationAdd BLAST22
DNA bindingi246 – 269H-T-H motifPROSITE-ProRule annotation1 PublicationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processArabinose catabolism, Carbohydrate metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:PD00242
ECOL316407:JW0063-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arabinose operon regulatory proteinCurated
Alternative name(s):
HTH-type transcriptional regulator AraCCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:araC1 Publication
Ordered Locus Names:b0064, JW0063
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi31Y → V: Eliminates the self-association, but does not affect regulation properties of the protein. 1 Publication1
Mutagenesisi209S → A: Defective in DNA binding. 1 Publication1
Mutagenesisi213H → A or Y: Defective in DNA binding. 1 Publication1
Mutagenesisi257D → A: Does not bind DNA. 1 Publication1
Mutagenesisi258Q → A: Defective in DNA binding. 1 Publication1
Mutagenesisi262S → A: Does not affect DNA binding. 1 Publication1

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03142 Alpha-L-Arabinose
DB04062 Beta-D-Fucose

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001944991 – 292Arabinose operon regulatory proteinAdd BLAST292

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0A9E0

PRoteomics IDEntifications database

More...
PRIDEi
P0A9E0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Negatively autoregulated (PubMed:328165, PubMed:6377308, PubMed:3279415). Autoregulation is either greatly reduced or nonexistent immediately after the addition of L-arabinose (PubMed:6377308). Transcription is stimulated by CRP in the presence of cAMP (PubMed:328165, PubMed:6377308).3 Publications

Gene expression databases

CollecTF database of bacterial transcription factor binding sites

More...
CollecTFi
EXPREG_000007d0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260828, 116 interactors
849182, 11 interactors

Database of interacting proteins

More...
DIPi
DIP-9125N

Protein interaction database and analysis system

More...
IntActi
P0A9E0, 12 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0064

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0A9E0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0A9E0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini180 – 279HTH araC/xylS-typePROSITE-ProRule annotationAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains an N-terminal domain that binds arabinose and mediates dimerization, an inter-domain linker region, and a C-terminal domain that binds DNA (PubMed:9103202, PubMed:9367758, PubMed:26800223). Arabinose is bound within a beta barrel and is completely buried by the N-terminal arm of the protein (PubMed:9103202). The DNA-binding domain contains seven helices arranged in two semi-independent subdomains, each containing one helix-turn-helix DNA binding motif, joined by a 19 residue central helix (PubMed:19422057).4 Publications

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41063TF Bacteria
ENOG4111G16 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276603

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0A9E0

KEGG Orthology (KO)

More...
KOi
K02099

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0A9E0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003313 AraC-bd
IPR009057 Homeobox-like_sf
IPR037923 HTH-like
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR020449 Tscrpt_reg_HTH_AraC-type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02311 AraC_binding, 1 hit
PF12833 HTH_18, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00032 HTHARAC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00342 HTH_ARAC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits
SSF51215 SSF51215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0A9E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAQNDPLL PGYSFNAHLV AGLTPIEANG YLDFFIDRPL GMKGYILNLT
60 70 80 90 100
IRGQGVVKNQ GREFVCRPGD ILLFPPGEIH HYGRHPEARE WYHQWVYFRP
110 120 130 140 150
RAYWHEWLNW PSIFANTGFF RPDEAHQPHF SDLFGQIINA GQGEGRYSEL
160 170 180 190 200
LAINLLEQLL LRRMEAINES LHPPMDNRVR EACQYISDHL ADSNFDIASV
210 220 230 240 250
AQHVCLSPSR LSHLFRQQLG ISVLSWREDQ RISQAKLLLS TTRMPIATVG
260 270 280 290
RNVGFDDQLY FSRVFKKCTG ASPSEFRAGC EEKVNDVAVK LS
Length:292
Mass (Da):33,384
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5A737E285A4ECC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7D → E in AAA23468 (PubMed:6160371).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00256 Genomic DNA Translation: CAA23507.1
V00259 Genomic DNA Translation: CAA23508.1
J01641 Genomic DNA Translation: AAA23466.1
U00096 Genomic DNA Translation: AAC73175.1
AP009048 Genomic DNA Translation: BAB96633.1
K01303 Genomic DNA Translation: AAA23468.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A91473 RGECA

NCBI Reference Sequences

More...
RefSeqi
NP_414606.1, NC_000913.3
WP_001300811.1, NZ_STEB01000010.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73175; AAC73175; b0064
BAB96633; BAB96633; BAB96633

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
944780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0063
eco:b0064

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.66

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00256 Genomic DNA Translation: CAA23507.1
V00259 Genomic DNA Translation: CAA23508.1
J01641 Genomic DNA Translation: AAA23466.1
U00096 Genomic DNA Translation: AAC73175.1
AP009048 Genomic DNA Translation: BAB96633.1
K01303 Genomic DNA Translation: AAA23468.1
PIRiA91473 RGECA
RefSeqiNP_414606.1, NC_000913.3
WP_001300811.1, NZ_STEB01000010.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XJAX-ray2.40A/B/C/D/E1-178[»]
2AACX-ray1.60A/B2-178[»]
2ARAX-ray2.80A19-167[»]
2ARCX-ray1.50A/B7-170[»]
2K9SNMR-A175-281[»]
SMRiP0A9E0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260828, 116 interactors
849182, 11 interactors
DIPiDIP-9125N
IntActiP0A9E0, 12 interactors
STRINGi511145.b0064

Chemistry databases

DrugBankiDB03142 Alpha-L-Arabinose
DB04062 Beta-D-Fucose

Proteomic databases

PaxDbiP0A9E0
PRIDEiP0A9E0

Genome annotation databases

EnsemblBacteriaiAAC73175; AAC73175; b0064
BAB96633; BAB96633; BAB96633
GeneIDi944780
KEGGiecj:JW0063
eco:b0064
PATRICifig|511145.12.peg.66

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0052

Phylogenomic databases

eggNOGiENOG41063TF Bacteria
ENOG4111G16 LUCA
HOGENOMiHOG000276603
InParanoidiP0A9E0
KOiK02099
PhylomeDBiP0A9E0

Enzyme and pathway databases

BioCyciEcoCyc:PD00242
ECOL316407:JW0063-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0A9E0

Protein Ontology

More...
PROi
PR:P0A9E0

Gene expression databases

CollecTFiEXPREG_000007d0

Family and domain databases

InterProiView protein in InterPro
IPR003313 AraC-bd
IPR009057 Homeobox-like_sf
IPR037923 HTH-like
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF02311 AraC_binding, 1 hit
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
SSF51215 SSF51215, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARAC_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A9E0
Secondary accession number(s): P03021, Q47056
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 13, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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