UniProtKB - P0A9C3 (GALM_ECOLI)
Protein
Aldose 1-epimerase
Gene
galM
Organism
Escherichia coli (strain K12)
Status
Functioni
Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.
Catalytic activityi
- EC:5.1.3.3PROSITE-ProRule annotation
: hexose metabolism Pathwayi
This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 79 | SubstrateBy similarity | 1 | |
Active sitei | 175 | Proton donorPROSITE-ProRule annotation | 1 | |
Binding sitei | 245 | SubstrateBy similarity | 1 | |
Active sitei | 309 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- aldose 1-epimerase activity Source: EcoCyc
- carbohydrate binding Source: InterPro
GO - Biological processi
- galactose catabolic process via UDP-galactose Source: EcoCyc
- glucose metabolic process Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:ALDOSE1EPIM-MONOMER MetaCyc:ALDOSE1EPIM-MONOMER |
BRENDAi | 5.1.3.B1, 2026 |
SABIO-RKi | P0A9C3 |
UniPathwayi | UPA00242 |
Names & Taxonomyi
Protein namesi | Recommended name: Aldose 1-epimerase (EC:5.1.3.3)Alternative name(s): Galactose mutarotase Type-1 mutarotase |
Gene namesi | Name:galM Ordered Locus Names:b0756, JW0739 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: EcoCyc
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197443 | 1 – 346 | Aldose 1-epimeraseAdd BLAST | 346 |
Proteomic databases
jPOSTi | P0A9C3 |
PaxDbi | P0A9C3 |
PRIDEi | P0A9C3 |
2D gel databases
SWISS-2DPAGEi | P0A9C3 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261710, 25 interactors |
DIPi | DIP-35901N |
IntActi | P0A9C3, 4 interactors |
STRINGi | 511145.b0756 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldose epimerase family.Curated
Phylogenomic databases
eggNOGi | COG2017, Bacteria |
HOGENOMi | CLU_031753_1_0_6 |
InParanoidi | P0A9C3 |
PhylomeDBi | P0A9C3 |
Family and domain databases
Gene3Di | 2.70.98.10, 1 hit |
InterProi | View protein in InterPro IPR018052, Ald1_epimerase_CS IPR013458, Ald_epimerase_bac IPR015443, Aldose_1-epimerase IPR008183, Aldose_1/G6P_1-epimerase IPR011013, Gal_mutarotase_sf_dom IPR014718, GH-type_carb-bd |
Pfami | View protein in Pfam PF01263, Aldose_epim, 1 hit |
PIRSFi | PIRSF005096, GALM, 1 hit |
SUPFAMi | SSF74650, SSF74650, 1 hit |
TIGRFAMsi | TIGR02636, galM_Leloir, 1 hit |
PROSITEi | View protein in PROSITE PS00545, ALDOSE_1_EPIMERASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A9C3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNETPALAP DGQPYRLLTL RNNAGMVVTL MDWGATLLSA RIPLSDGSVR
60 70 80 90 100
EALLGCASPE CYQDQAAFLG ASIGRYANRI ANSRYTFDGE TVTLSPSQGV
110 120 130 140 150
NQLHGGPEGF DKRRWQIVNQ NDRQVLFALS SDDGDQGFPG NLGATVQYRL
160 170 180 190 200
TDDNRISITY RATVDKPCPV NMTNHVYFNL DGEQSDVRNH KLQILADEYL
210 220 230 240 250
PVDEGGIPHD GLKSVAGTSF DFRSAKIIAS EFLADDDQRK VKGYDHAFLL
260 270 280 290 300
QAKGDGKKVA AHVWSADEKL QLKVYTTAPA LQFYSGNFLG GTPSRGTEPY
310 320 330 340
ADWQGLALES EFLPDSPNHP EWPQPDCFLR PGEEYSSLTE YQFIAE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13636 Genomic DNA Translation: AAB17020.1 U00096 Genomic DNA Translation: AAC73843.1 AP009048 Genomic DNA Translation: BAA35418.1 |
PIRi | D64811 |
RefSeqi | NP_415277.1, NC_000913.3 WP_000931389.1, NZ_STEB01000028.1 |
Genome annotation databases
EnsemblBacteriai | AAC73843; AAC73843; b0756 BAA35418; BAA35418; BAA35418 |
GeneIDi | 58392324 944943 |
KEGGi | ecj:JW0739 eco:b0756 |
PATRICi | fig|1411691.4.peg.1522 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13636 Genomic DNA Translation: AAB17020.1 U00096 Genomic DNA Translation: AAC73843.1 AP009048 Genomic DNA Translation: BAA35418.1 |
PIRi | D64811 |
RefSeqi | NP_415277.1, NC_000913.3 WP_000931389.1, NZ_STEB01000028.1 |
3D structure databases
SMRi | P0A9C3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261710, 25 interactors |
DIPi | DIP-35901N |
IntActi | P0A9C3, 4 interactors |
STRINGi | 511145.b0756 |
2D gel databases
SWISS-2DPAGEi | P0A9C3 |
Proteomic databases
jPOSTi | P0A9C3 |
PaxDbi | P0A9C3 |
PRIDEi | P0A9C3 |
Genome annotation databases
EnsemblBacteriai | AAC73843; AAC73843; b0756 BAA35418; BAA35418; BAA35418 |
GeneIDi | 58392324 944943 |
KEGGi | ecj:JW0739 eco:b0756 |
PATRICi | fig|1411691.4.peg.1522 |
Organism-specific databases
EchoBASEi | EB1649 |
Phylogenomic databases
eggNOGi | COG2017, Bacteria |
HOGENOMi | CLU_031753_1_0_6 |
InParanoidi | P0A9C3 |
PhylomeDBi | P0A9C3 |
Enzyme and pathway databases
UniPathwayi | UPA00242 |
BioCyci | EcoCyc:ALDOSE1EPIM-MONOMER MetaCyc:ALDOSE1EPIM-MONOMER |
BRENDAi | 5.1.3.B1, 2026 |
SABIO-RKi | P0A9C3 |
Miscellaneous databases
PROi | PR:P0A9C3 |
Family and domain databases
Gene3Di | 2.70.98.10, 1 hit |
InterProi | View protein in InterPro IPR018052, Ald1_epimerase_CS IPR013458, Ald_epimerase_bac IPR015443, Aldose_1-epimerase IPR008183, Aldose_1/G6P_1-epimerase IPR011013, Gal_mutarotase_sf_dom IPR014718, GH-type_carb-bd |
Pfami | View protein in Pfam PF01263, Aldose_epim, 1 hit |
PIRSFi | PIRSF005096, GALM, 1 hit |
SUPFAMi | SSF74650, SSF74650, 1 hit |
TIGRFAMsi | TIGR02636, galM_Leloir, 1 hit |
PROSITEi | View protein in PROSITE PS00545, ALDOSE_1_EPIMERASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GALM_ECOLI | |
Accessioni | P0A9C3Primary (citable) accession number: P0A9C3 Secondary accession number(s): P40681 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families