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Protein

Ferric uptake regulation protein

Gene

fur

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a global negative controlling element, employing Fe2+ as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon.1 Publication

Miscellaneous

Activated by cadmium, cobalt, copper, and manganese ions, but not zinc ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33ZincBy similarity1
Metal bindingi81ZincBy similarity1
Metal bindingi87IronBy similarity1
Metal bindingi89IronBy similarity1
Metal bindingi90ZincBy similarity1
Metal bindingi93Zinc1
Metal bindingi96Zinc1
Metal bindingi101ZincBy similarity1
Metal bindingi108IronBy similarity1
Metal bindingi125IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:PD00260

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric uptake regulation protein
Short name:
Ferric uptake regulator
Gene namesi
Name:fur
Ordered Locus Names:b0683, JW0669
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10359 fur

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000955502 – 148Ferric uptake regulation proteinAdd BLAST147

Proteomic databases

EPDiP0A9A9
PaxDbiP0A9A9
PRIDEiP0A9A9

2D gel databases

SWISS-2DPAGEiP0A9A9

Expressioni

Gene expression databases

CollecTFiEXPREG_000007c0

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi4262110, 43 interactors
849672, 1 interactor
DIPiDIP-31858N
IntActiP0A9A9, 50 interactors
STRINGi316385.ECDH10B_0748

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0A9A9
SMRiP0A9A9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9A9

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 84DNA-bindingBy similarityAdd BLAST83
Regioni85 – 148DimerizationBy similarityAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 90His-rich5

Sequence similaritiesi

Belongs to the Fur family.Curated

Phylogenomic databases

eggNOGiENOG41090R7 Bacteria
COG0735 LUCA
HOGENOMiHOG000014144
InParanoidiP0A9A9
KOiK03711
PhylomeDBiP0A9A9

Family and domain databases

CDDicd07153 Fur_like, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR002481 FUR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR33202 PTHR33202, 1 hit
PfamiView protein in Pfam
PF01475 FUR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9A9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDNNTALKK AGLKVTLPRL KILEVLQEPD NHHVSAEDLY KRLIDMGEEI
60 70 80 90 100
GLATVYRVLN QFDDAGIVTR HNFEGGKSVF ELTQQHHHDH LICLDCGKVI
110 120 130 140
EFSDDSIEAR QREIAAKHGI RLTNHSLYLY GHCAEGDCRE DEHAHEGK
Length:148
Mass (Da):16,795
Last modified:April 1, 1988 - v1
Checksum:iB868360513489DD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02589 Genomic DNA Translation: CAA26429.1
U00096 Genomic DNA Translation: AAC73777.1
AP009048 Genomic DNA Translation: BAA35331.1
PIRiS07308
RefSeqiNP_415209.1, NC_000913.3
WP_000131702.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73777; AAC73777; b0683
BAA35331; BAA35331; BAA35331
GeneIDi945295
KEGGiecj:JW0669
eco:b0683
PATRICifig|1411691.4.peg.1593

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02589 Genomic DNA Translation: CAA26429.1
U00096 Genomic DNA Translation: AAC73777.1
AP009048 Genomic DNA Translation: BAA35331.1
PIRiS07308
RefSeqiNP_415209.1, NC_000913.3
WP_000131702.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FU4X-ray1.80A/B1-83[»]
ProteinModelPortaliP0A9A9
SMRiP0A9A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262110, 43 interactors
849672, 1 interactor
DIPiDIP-31858N
IntActiP0A9A9, 50 interactors
STRINGi316385.ECDH10B_0748

2D gel databases

SWISS-2DPAGEiP0A9A9

Proteomic databases

EPDiP0A9A9
PaxDbiP0A9A9
PRIDEiP0A9A9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73777; AAC73777; b0683
BAA35331; BAA35331; BAA35331
GeneIDi945295
KEGGiecj:JW0669
eco:b0683
PATRICifig|1411691.4.peg.1593

Organism-specific databases

EchoBASEiEB0354
EcoGeneiEG10359 fur

Phylogenomic databases

eggNOGiENOG41090R7 Bacteria
COG0735 LUCA
HOGENOMiHOG000014144
InParanoidiP0A9A9
KOiK03711
PhylomeDBiP0A9A9

Enzyme and pathway databases

BioCyciEcoCyc:PD00260

Miscellaneous databases

EvolutionaryTraceiP0A9A9
PROiPR:P0A9A9

Gene expression databases

CollecTFiEXPREG_000007c0

Family and domain databases

CDDicd07153 Fur_like, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR002481 FUR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR33202 PTHR33202, 1 hit
PfamiView protein in Pfam
PF01475 FUR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFUR_ECOLI
AccessioniPrimary (citable) accession number: P0A9A9
Secondary accession number(s): P06975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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