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UniProtKB - P0A954 (FABB_ECOL6)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 1
Gene
fabB
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Functioni
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can also use unsaturated fatty acids. Catalyzes a key reaction in unsaturated fatty acid (UFA) synthesis, the elongation of the cis-3-decenoyl-ACP produced by FabA.
By similarityCatalytic activityi
- EC:2.3.1.41By similarityThis reaction proceeds in the forwardBy similarity direction.
- (3Z)-decenoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]By similarityThis reaction proceeds in the forwardBy similarity direction.
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 163 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | ECOL199310:C2869-MONOMER |
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 1By similarity (EC:2.3.1.41By similarity)Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase IBy similarity Beta-ketoacyl-ACP synthase IBy similarity Short name: KAS IBy similarity |
Gene namesi | Name:fabB Ordered Locus Names:c2869 |
Organismi | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) |
Taxonomic identifieri | 199310 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180312 | 1 – 406 | 3-oxoacyl-[acyl-carrier-protein] synthase 1Add BLAST | 406 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 199310.c2869 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_6 |
OMAi | YAYLSMQ |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A954-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRAVITGLG IVSSIGNNQQ EVLASLREGR SGITFSQELK DSGMRSHVWG
60 70 80 90 100
NVKLDTTGLI DRKVVRFMSD ASIYAFLSME QAIADAGLSP EAYQNNPRVG
110 120 130 140 150
LIAGSGGGSP RFQVFGADAM RGPRGLKAVG PYVVTKAMAS GVSACLATPF
160 170 180 190 200
KIHGVNYSIS SACATSAHCI GNAVEQIQLG KQDIVFAGGG EELCWEMACE
210 220 230 240 250
FDAMGALSTK YNDTPEKASR TYDAHRDGFV IAGGGGMVVV EELEHALARG
260 270 280 290 300
AHIYAEIVGY GATSDGADMV APSGEGAVRC MKMAMHGVDT PIDYLNSHGT
310 320 330 340 350
STPVGDVKEL AAIREVFGDK SPAISATKAM TGHSLGAAGV QEAIYSLLML
360 370 380 390 400
EHGFIAPSIN IEELDEQAAG LNIVTETTDR ELTTVMSNSF GFGGTNATLV
MRKLKD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN81319.1 |
RefSeqi | WP_000817178.1, NC_004431.1 |
Genome annotation databases
EnsemblBacteriai | AAN81319; AAN81319; c2869 |
GeneIDi | 67416753 |
KEGGi | ecc:c2869 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN81319.1 |
RefSeqi | WP_000817178.1, NC_004431.1 |
3D structure databases
SMRi | P0A954 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 199310.c2869 |
Genome annotation databases
EnsemblBacteriai | AAN81319; AAN81319; c2869 |
GeneIDi | 67416753 |
KEGGi | ecc:c2869 |
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_6 |
OMAi | YAYLSMQ |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
BioCyci | ECOL199310:C2869-MONOMER |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABB_ECOL6 | |
Accessioni | P0A954Primary (citable) accession number: P0A954 Secondary accession number(s): P14926 Q9R830 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families