UniProtKB - P0A953 (FABB_ECOLI)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 1
Gene
fabB
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.1 Publication
Catalytic activityi
- EC:2.3.1.41
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 163 | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: EcoCyc
GO - Biological processi
- fatty acid biosynthetic process Source: EcoCyc
- lipid biosynthetic process Source: EcoliWiki
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:FABB-MONOMER MetaCyc:FABB-MONOMER |
BRENDAi | 2.3.1.41, 2026 |
UniPathwayi | UPA00094 |
Chemistry databases
SwissLipidsi | SLP:000001786 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase I Beta-ketoacyl-ACP synthase I Short name: KAS I |
Gene namesi | Name:fabB Synonyms:fabC Ordered Locus Names:b2323, JW2320 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytosol Source: EcoCyc
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4913 |
DrugBanki | DB08627, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE DB08628, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE DB08359, 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE DB04302, 4-Hydroxy-3,5-Dimethyl-5-(2-Methyl-Buta-1,3-Dienyl)-5h-Thiophen-2-One DB03600, Capric acid DB04519, Caprylic acid DB01034, Cerulenin DB03017, Lauric acid |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180311 | 1 – 406 | 3-oxoacyl-[acyl-carrier-protein] synthase 1Add BLAST | 406 |
Proteomic databases
jPOSTi | P0A953 |
PaxDbi | P0A953 |
PRIDEi | P0A953 |
Expressioni
Inductioni
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGRIDi | 4260793, 224 interactors |
DIPi | DIP-29379N |
IntActi | P0A953, 9 interactors |
STRINGi | 511145.b2323 |
Chemistry databases
BindingDBi | P0A953 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0A953 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A953 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_6 |
InParanoidi | P0A953 |
PhylomeDBi | P0A953 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0A953-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRAVITGLG IVSSIGNNQQ EVLASLREGR SGITFSQELK DSGMRSHVWG
60 70 80 90 100
NVKLDTTGLI DRKVVRFMSD ASIYAFLSME QAIADAGLSP EAYQNNPRVG
110 120 130 140 150
LIAGSGGGSP RFQVFGADAM RGPRGLKAVG PYVVTKAMAS GVSACLATPF
160 170 180 190 200
KIHGVNYSIS SACATSAHCI GNAVEQIQLG KQDIVFAGGG EELCWEMACE
210 220 230 240 250
FDAMGALSTK YNDTPEKASR TYDAHRDGFV IAGGGGMVVV EELEHALARG
260 270 280 290 300
AHIYAEIVGY GATSDGADMV APSGEGAVRC MKMAMHGVDT PIDYLNSHGT
310 320 330 340 350
STPVGDVKEL AAIREVFGDK SPAISATKAM TGHSLGAAGV QEAIYSLLML
360 370 380 390 400
EHGFIAPSIN IEELDEQAAG LNIVTETTDR ELTTVMSNSF GFGGTNATLV
MRKLKD
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 4 | A → T in strain: MA-1 / fabB3. | 1 | |
Natural varianti | 140 | S → F in strain: K1060 / fabB5. | 1 | |
Natural varianti | 299 | G → S in strain: MA-1 / fabB3. | 1 | |
Natural varianti | 329 | A → V in strain: M5 / fabB15. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24427 Genomic DNA Translation: AAC67304.1 AJ012161 Genomic DNA Translation: CAA09932.1 AJ012162 Genomic DNA Translation: CAA09933.1 AJ012163 Genomic DNA Translation: CAA09934.1 U00096 Genomic DNA Translation: AAC75383.1 AP009048 Genomic DNA Translation: BAA16180.1 |
PIRi | A31284, SYECA1 |
RefSeqi | NP_416826.1, NC_000913.3 WP_000817178.1, NZ_SSZK01000006.1 |
Genome annotation databases
EnsemblBacteriai | AAC75383; AAC75383; b2323 BAA16180; BAA16180; BAA16180 |
GeneIDi | 52077639 946799 |
KEGGi | ecj:JW2320 eco:b2323 |
PATRICi | fig|1411691.4.peg.4409 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24427 Genomic DNA Translation: AAC67304.1 AJ012161 Genomic DNA Translation: CAA09932.1 AJ012162 Genomic DNA Translation: CAA09933.1 AJ012163 Genomic DNA Translation: CAA09934.1 U00096 Genomic DNA Translation: AAC75383.1 AP009048 Genomic DNA Translation: BAA16180.1 |
PIRi | A31284, SYECA1 |
RefSeqi | NP_416826.1, NC_000913.3 WP_000817178.1, NZ_SSZK01000006.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DD8 | X-ray | 2.30 | A/B/C/D | 1-406 | [»] | |
1EK4 | X-ray | 1.85 | A/B/C/D | 1-406 | [»] | |
1F91 | X-ray | 2.40 | A/B/C/D | 1-406 | [»] | |
1FJ4 | X-ray | 2.35 | A/B/C/D | 1-406 | [»] | |
1FJ8 | X-ray | 2.27 | A/B/C/D | 1-406 | [»] | |
1G5X | X-ray | 2.45 | A/B/C/D | 1-406 | [»] | |
1H4F | X-ray | 2.00 | A/B/C/D | 1-406 | [»] | |
2AQ7 | X-ray | 2.30 | A/B/C/D | 1-406 | [»] | |
2AQB | X-ray | 2.19 | A/B/C/D | 1-406 | [»] | |
2BUH | X-ray | 1.90 | A/B/C/D | 1-406 | [»] | |
2BUI | X-ray | 2.40 | A/B/C/D | 1-406 | [»] | |
2BYW | X-ray | 1.70 | A/B/C/D | 1-406 | [»] | |
2BYX | X-ray | 2.00 | A/B/C/D | 1-406 | [»] | |
2BYY | X-ray | 2.20 | A/B/C/D | 1-406 | [»] | |
2BYZ | X-ray | 1.95 | A/B/C/D | 1-406 | [»] | |
2BZ3 | X-ray | 2.00 | A/B/C/D | 1-406 | [»] | |
2BZ4 | X-ray | 1.86 | A/B/C/D | 1-406 | [»] | |
2CDH | X-ray | 4.20 | A/B/C/D/E/F | 1-406 | [»] | |
2CF2 | X-ray | 4.30 | A/J | 1-406 | [»] | |
2VB7 | X-ray | 1.60 | A/B/C/D | 1-406 | [»] | |
2VB8 | X-ray | 1.52 | A/B/C/D | 1-406 | [»] | |
2VB9 | X-ray | 1.50 | A/B/C/D | 1-406 | [»] | |
2VBA | X-ray | 1.36 | A/B/C/D | 1-406 | [»] | |
5KOF | X-ray | 2.40 | A/B | 1-406 | [»] | |
6OKC | X-ray | 1.55 | A/B | 1-406 | [»] | |
6OKF | X-ray | 2.50 | A/B | 1-406 | [»] | |
SMRi | P0A953 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260793, 224 interactors |
DIPi | DIP-29379N |
IntActi | P0A953, 9 interactors |
STRINGi | 511145.b2323 |
Chemistry databases
BindingDBi | P0A953 |
ChEMBLi | CHEMBL4913 |
DrugBanki | DB08627, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE DB08628, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE DB08359, 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE DB04302, 4-Hydroxy-3,5-Dimethyl-5-(2-Methyl-Buta-1,3-Dienyl)-5h-Thiophen-2-One DB03600, Capric acid DB04519, Caprylic acid DB01034, Cerulenin DB03017, Lauric acid |
SwissLipidsi | SLP:000001786 |
Proteomic databases
jPOSTi | P0A953 |
PaxDbi | P0A953 |
PRIDEi | P0A953 |
Genome annotation databases
EnsemblBacteriai | AAC75383; AAC75383; b2323 BAA16180; BAA16180; BAA16180 |
GeneIDi | 52077639 946799 |
KEGGi | ecj:JW2320 eco:b2323 |
PATRICi | fig|1411691.4.peg.4409 |
Organism-specific databases
EchoBASEi | EB0270 |
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_6 |
InParanoidi | P0A953 |
PhylomeDBi | P0A953 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
BioCyci | EcoCyc:FABB-MONOMER MetaCyc:FABB-MONOMER |
BRENDAi | 2.3.1.41, 2026 |
Miscellaneous databases
EvolutionaryTracei | P0A953 |
PROi | PR:P0A953 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FABB_ECOLI | |
Accessioni | P0A953Primary (citable) accession number: P0A953 Secondary accession number(s): P14926 Q9R830 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families