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Entry version 136 (02 Jun 2021)
Sequence version 1 (19 Jul 2005)
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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene

fabB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:9013860, PubMed:8910376, PubMed:19679654, PubMed:22017312).

Can also use unsaturated fatty acids (PubMed:3076377, PubMed:8910376, PubMed:19679654).

Catalyzes a key reaction in unsaturated fatty acid (UFA) synthesis, the elongation of the cis-3-decenoyl-ACP produced by FabA (PubMed:19679654).

Can use acyl chains from C-6 to C-14 (PubMed:9013860, PubMed:8910376, PubMed:19679654, PubMed:22017312).

Has an absolute requirement for an ACP substrate as the acyl donor, and no activity is detected when both substrates are based on CoA (PubMed:22017312).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 6.6 min(-1) with malonyl-[ACP] as substrate in the presence of dodecanoyl-[ACP]. kcat is 3.4 min(-1) with dodecanoyl-[ACP] in the presence of malonyl-[ACP].1 Publication
  1. KM=11.5 µM for malonyl-[ACP] (in the presence of dodecanoyl-[ACP])1 Publication
  2. KM=3.2 µM for dodecanoyl-[ACP] (in the presence of malonyl-[ACP])1 Publication
  3. KM=153 µM for malonyl-CoA (in the presence of dodecanoyl-[ACP])1 Publication
  4. KM=58.6 µM for dodecanoyl-CoA (in the presence of malonyl-[ACP])1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

    This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.2 Publications
    View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1631 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: EcoCyc

    GO - Biological processi

    • fatty acid biosynthetic process Source: EcoCyc
    • lipid biosynthetic process Source: EcoliWiki

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase
    Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:FABB-MONOMER
    MetaCyc:FABB-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.3.1.41, 2026

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00094

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001786

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 1Curated (EC:2.3.1.414 Publications)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase ICurated
    Beta-ketoacyl-ACP synthase I1 Publication
    Short name:
    KAS I
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:fabB1 Publication
    Synonyms:fabC
    Ordered Locus Names:b2323, JW2320
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4913

    Drug and drug target database

    More...
    DrugBanki
    DB08627, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE
    DB08628, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE
    DB08359, 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE
    DB04302, 4-Hydroxy-3,5-Dimethyl-5-(2-Methyl-Buta-1,3-Dienyl)-5h-Thiophen-2-One
    DB03600, Capric acid
    DB04519, Caprylic acid
    DB01034, Cerulenin
    DB03017, Lauric acid

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001803111 – 4063-oxoacyl-[acyl-carrier-protein] synthase 1Add BLAST406

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P0A953

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P0A953

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P0A953

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Mainly activated by FadR, but minor repression is also conferred by FabR (PubMed:11859088, PubMed:21276098).2 Publications

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4260793, 224 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-29379N

    Protein interaction database and analysis system

    More...
    IntActi
    P0A953, 9 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b2323

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P0A953

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1406
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P0A953

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P0A953

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG0304, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_000022_69_2_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P0A953

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P0A953

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00834, KAS_I_II, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.47.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000794, Beta-ketoacyl_synthase
    IPR018201, Ketoacyl_synth_AS
    IPR014031, Ketoacyl_synth_C
    IPR014030, Ketoacyl_synth_N
    IPR020841, PKS_Beta-ketoAc_synthase_dom
    IPR016039, Thiolase-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11712, PTHR11712, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00109, ketoacyl-synt, 1 hit
    PF02801, Ketoacyl-synt_C, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00825, PKS_KS, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53901, SSF53901, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00606, B_KETOACYL_SYNTHASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P0A953-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKRAVITGLG IVSSIGNNQQ EVLASLREGR SGITFSQELK DSGMRSHVWG
    60 70 80 90 100
    NVKLDTTGLI DRKVVRFMSD ASIYAFLSME QAIADAGLSP EAYQNNPRVG
    110 120 130 140 150
    LIAGSGGGSP RFQVFGADAM RGPRGLKAVG PYVVTKAMAS GVSACLATPF
    160 170 180 190 200
    KIHGVNYSIS SACATSAHCI GNAVEQIQLG KQDIVFAGGG EELCWEMACE
    210 220 230 240 250
    FDAMGALSTK YNDTPEKASR TYDAHRDGFV IAGGGGMVVV EELEHALARG
    260 270 280 290 300
    AHIYAEIVGY GATSDGADMV APSGEGAVRC MKMAMHGVDT PIDYLNSHGT
    310 320 330 340 350
    STPVGDVKEL AAIREVFGDK SPAISATKAM TGHSLGAAGV QEAIYSLLML
    360 370 380 390 400
    EHGFIAPSIN IEELDEQAAG LNIVTETTDR ELTTVMSNSF GFGGTNATLV

    MRKLKD
    Length:406
    Mass (Da):42,613
    Last modified:July 19, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i489D8BAD23E78113
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti4A → T in strain: MA-1 / fabB3. 1
    Natural varianti140S → F in strain: K1060 / fabB5. 1
    Natural varianti299G → S in strain: MA-1 / fabB3. 1
    Natural varianti329A → V in strain: M5 / fabB15. 1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M24427 Genomic DNA Translation: AAC67304.1
    AJ012161 Genomic DNA Translation: CAA09932.1
    AJ012162 Genomic DNA Translation: CAA09933.1
    AJ012163 Genomic DNA Translation: CAA09934.1
    U00096 Genomic DNA Translation: AAC75383.1
    AP009048 Genomic DNA Translation: BAA16180.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A31284, SYECA1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_416826.1, NC_000913.3
    WP_000817178.1, NZ_SSZK01000006.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC75383; AAC75383; b2323
    BAA16180; BAA16180; BAA16180

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    61754615
    946799

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW2320
    eco:b2323

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.4409

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M24427 Genomic DNA Translation: AAC67304.1
    AJ012161 Genomic DNA Translation: CAA09932.1
    AJ012162 Genomic DNA Translation: CAA09933.1
    AJ012163 Genomic DNA Translation: CAA09934.1
    U00096 Genomic DNA Translation: AAC75383.1
    AP009048 Genomic DNA Translation: BAA16180.1
    PIRiA31284, SYECA1
    RefSeqiNP_416826.1, NC_000913.3
    WP_000817178.1, NZ_SSZK01000006.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1DD8X-ray2.30A/B/C/D1-406[»]
    1EK4X-ray1.85A/B/C/D1-406[»]
    1F91X-ray2.40A/B/C/D1-406[»]
    1FJ4X-ray2.35A/B/C/D1-406[»]
    1FJ8X-ray2.27A/B/C/D1-406[»]
    1G5XX-ray2.45A/B/C/D1-406[»]
    1H4FX-ray2.00A/B/C/D1-406[»]
    2AQ7X-ray2.30A/B/C/D1-406[»]
    2AQBX-ray2.19A/B/C/D1-406[»]
    2BUHX-ray1.90A/B/C/D1-406[»]
    2BUIX-ray2.40A/B/C/D1-406[»]
    2BYWX-ray1.70A/B/C/D1-406[»]
    2BYXX-ray2.00A/B/C/D1-406[»]
    2BYYX-ray2.20A/B/C/D1-406[»]
    2BYZX-ray1.95A/B/C/D1-406[»]
    2BZ3X-ray2.00A/B/C/D1-406[»]
    2BZ4X-ray1.86A/B/C/D1-406[»]
    2CDHX-ray4.20A/B/C/D/E/F1-406[»]
    2CF2X-ray4.30A/J1-406[»]
    2VB7X-ray1.60A/B/C/D1-406[»]
    2VB8X-ray1.52A/B/C/D1-406[»]
    2VB9X-ray1.50A/B/C/D1-406[»]
    2VBAX-ray1.36A/B/C/D1-406[»]
    5KOFX-ray2.40A/B1-406[»]
    6OKCX-ray1.55A/B1-406[»]
    6OKFX-ray2.50A/B1-406[»]
    SMRiP0A953
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi4260793, 224 interactors
    DIPiDIP-29379N
    IntActiP0A953, 9 interactors
    STRINGi511145.b2323

    Chemistry databases

    BindingDBiP0A953
    ChEMBLiCHEMBL4913
    DrugBankiDB08627, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE
    DB08628, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE
    DB08359, 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE
    DB04302, 4-Hydroxy-3,5-Dimethyl-5-(2-Methyl-Buta-1,3-Dienyl)-5h-Thiophen-2-One
    DB03600, Capric acid
    DB04519, Caprylic acid
    DB01034, Cerulenin
    DB03017, Lauric acid
    SwissLipidsiSLP:000001786

    Proteomic databases

    jPOSTiP0A953
    PaxDbiP0A953
    PRIDEiP0A953

    Genome annotation databases

    EnsemblBacteriaiAAC75383; AAC75383; b2323
    BAA16180; BAA16180; BAA16180
    GeneIDi61754615
    946799
    KEGGiecj:JW2320
    eco:b2323
    PATRICifig|1411691.4.peg.4409

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0270

    Phylogenomic databases

    eggNOGiCOG0304, Bacteria
    HOGENOMiCLU_000022_69_2_6
    InParanoidiP0A953
    PhylomeDBiP0A953

    Enzyme and pathway databases

    UniPathwayiUPA00094
    BioCyciEcoCyc:FABB-MONOMER
    MetaCyc:FABB-MONOMER
    BRENDAi2.3.1.41, 2026

    Miscellaneous databases

    EvolutionaryTraceiP0A953

    Protein Ontology

    More...
    PROi
    PR:P0A953

    Family and domain databases

    CDDicd00834, KAS_I_II, 1 hit
    Gene3Di3.40.47.10, 2 hits
    InterProiView protein in InterPro
    IPR000794, Beta-ketoacyl_synthase
    IPR018201, Ketoacyl_synth_AS
    IPR014031, Ketoacyl_synth_C
    IPR014030, Ketoacyl_synth_N
    IPR020841, PKS_Beta-ketoAc_synthase_dom
    IPR016039, Thiolase-like
    PANTHERiPTHR11712, PTHR11712, 1 hit
    PfamiView protein in Pfam
    PF00109, ketoacyl-synt, 1 hit
    PF02801, Ketoacyl-synt_C, 1 hit
    SMARTiView protein in SMART
    SM00825, PKS_KS, 1 hit
    SUPFAMiSSF53901, SSF53901, 2 hits
    PROSITEiView protein in PROSITE
    PS00606, B_KETOACYL_SYNTHASE, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFABB_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0A953
    Secondary accession number(s): P14926
    , Q9R828, Q9R829, Q9R830
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: June 2, 2021
    This is version 136 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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