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Protein

Nucleoside-specific channel-forming protein Tsx

Gene

tsx

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as substrate-specific channel for nucleosides and deoxynucleosides (PubMed:791677, PubMed:3276691, PubMed:2458926). Has a greater affinity for deoxynucleosides than for nucleosides, and does not transport free bases (PubMed:2458926). In addition, constitutes the receptor for colicin K and phage T6 (PubMed:791677, PubMed:3276691).3 Publications

GO - Molecular functioni

  • nucleoside-specific channel forming porin activity Source: EcoCyc

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • nucleoside transport Source: EcoCyc
  • viral entry into host cell Source: EcoCyc

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11035-MONOMER
MetaCyc:EG11035-MONOMER

Protein family/group databases

TCDBi1.B.10.1.1 the nucleoside-specific channel-forming outer membrane porin (tsx) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside-specific channel-forming protein TsxCurated
Gene namesi
Name:tsx1 Publication
Synonyms:nupA
Ordered Locus Names:b0411, JW0401
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11035 tsx

Subcellular locationi

  • Cell outer membrane 2 Publications; Multi-pass membrane protein 2 Publications

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • pore complex Source: EcoCyc

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB04485 Deoxythymidine
DB02745 Uridine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002519023 – 294Nucleoside-specific channel-forming protein TsxAdd BLAST272

Proteomic databases

EPDiP0A927
PaxDbiP0A927
PRIDEiP0A927

Interactioni

Protein-protein interaction databases

BioGridi4263182, 129 interactors
STRINGi316385.ECDH10B_0367

Structurei

Secondary structure

1294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni32 – 34Combined sources3
Beta strandi35 – 47Combined sources13
Beta strandi49 – 52Combined sources4
Beta strandi57 – 67Combined sources11
Beta strandi70 – 79Combined sources10
Beta strandi99 – 107Combined sources9
Helixi108 – 112Combined sources5
Beta strandi121 – 133Combined sources13
Beta strandi136 – 140Combined sources5
Beta strandi142 – 153Combined sources12
Beta strandi156 – 173Combined sources18
Beta strandi180 – 198Combined sources19
Beta strandi201 – 213Combined sources13
Turni217 – 219Combined sources3
Beta strandi227 – 231Combined sources5
Beta strandi235 – 245Combined sources11
Beta strandi247 – 260Combined sources14
Helixi261 – 263Combined sources3
Beta strandi269 – 274Combined sources6
Beta strandi276 – 278Combined sources3
Beta strandi282 – 294Combined sources13

3D structure databases

ProteinModelPortaliP0A927
SMRiP0A927
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A927

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105DRB Bacteria
COG3248 LUCA
HOGENOMiHOG000273630
KOiK05517
OMAiKSTGWGY

Family and domain databases

Gene3Di2.40.230.20, 1 hit
InterProiView protein in InterPro
IPR003055 Channel_Tsx
IPR018013 Channel_Tsx-like
IPR036777 Channel_Tsx-like_sf
PfamiView protein in Pfam
PF03502 Channel_Tsx, 1 hit
PRINTSiPR01277 CHANNELTSX
SUPFAMiSSF111364 SSF111364, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTLLAAGA VLALSSSFTV NAAENDKPQY LSDWWHQSVN VVGSYHTRFG
60 70 80 90 100
PQIRNDTYLE YEAFAKKDWF DFYGYADAPV FFGGNSDAKG IWNHGSPLFM
110 120 130 140 150
EIEPRFSIDK LTNTDLSFGP FKEWYFANNY IYDMGRNKDG RQSTWYMGLG
160 170 180 190 200
TDIDTGLPMS LSMNVYAKYQ WQNYGAANEN EWDGYRFKIK YFVPITDLWG
210 220 230 240 250
GQLSYIGFTN FDWGSDLGDD SGNAINGIKT RTNNSIASSH ILALNYDHWH
260 270 280 290
YSVVARYWHD GGQWNDDAEL NFGNGNFNVR STGWGGYLVV GYNF
Length:294
Mass (Da):33,589
Last modified:July 19, 2005 - v1
Checksum:iAB801DC563552A5C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti276N → Y in phage resistant mutant. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57685 Genomic DNA Translation: AAA24701.1
U82664 Genomic DNA Translation: AAB40167.1
U00096 Genomic DNA Translation: AAC73514.1
AP009048 Genomic DNA Translation: BAE76191.1
PIRiJQ0798
RefSeqiNP_414945.1, NC_000913.3
WP_001295328.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73514; AAC73514; b0411
BAE76191; BAE76191; BAE76191
GeneIDi946242
KEGGiecj:JW0401
eco:b0411
PATRICifig|1411691.4.peg.1866

Similar proteinsi

Entry informationi

Entry nameiTSX_ECOLI
AccessioniPrimary (citable) accession number: P0A927
Secondary accession number(s): P22786, Q2MC15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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