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Protein

Outer membrane protein W

Gene

ompW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a receptor for colicin S4.1 Publication

Enzyme and pathway databases

BioCyciEcoCyc:EG11124-MONOMER

Protein family/group databases

TCDBi1.B.39.1.6 the bacterial porin, ompw (ompw) family

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein W
Gene namesi
Name:ompW
Synonyms:yciD
Ordered Locus Names:b1256, JW1248
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11124 ompW

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane
DB04147 Lauryl Dimethylamine-N-Oxide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000002019022 – 212Outer membrane protein WAdd BLAST191

Proteomic databases

PaxDbiP0A915
PRIDEiP0A915

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
frdBP0AC472EBI-1132929,EBI-906724

Protein-protein interaction databases

BioGridi4263000, 230 interactors
IntActiP0A915, 5 interactors
MINTiP0A915
STRINGi316385.ECDH10B_1371

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 37Combined sources11
Beta strandi57 – 80Combined sources24
Beta strandi82 – 88Combined sources7
Turni89 – 91Combined sources3
Beta strandi92 – 100Combined sources9
Beta strandi103 – 109Combined sources7
Beta strandi116 – 135Combined sources20
Helixi137 – 141Combined sources5
Beta strandi144 – 149Combined sources6
Beta strandi152 – 164Combined sources13
Beta strandi166 – 178Combined sources13
Beta strandi181 – 190Combined sources10
Beta strandi195 – 198Combined sources4
Beta strandi202 – 212Combined sources11

3D structure databases

ProteinModelPortaliP0A915
SMRiP0A915
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A915

Family & Domainsi

Sequence similaritiesi

Belongs to the OmpW/AlkL family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105EIF Bacteria
COG3047 LUCA
HOGENOMiHOG000217796
InParanoidiP0A915
KOiK07275
OMAiPWVYMVG
PhylomeDBiP0A915

Family and domain databases

InterProiView protein in InterPro
IPR011250 OMP/PagP_b-brl
IPR005618 OMPW
PANTHERiPTHR36920 PTHR36920, 1 hit
PfamiView protein in Pfam
PF03922 OmpW, 1 hit
SUPFAMiSSF56925 SSF56925, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLTVAALA VTTLLSGSAF AHEAGEFFMR AGSATVRPTE GAGGTLGSLG
60 70 80 90 100
GFSVTNNTQL GLTFTYMATD NIGVELLAAT PFRHKIGTRA TGDIATVHHL
110 120 130 140 150
PPTLMAQWYF GDASSKFRPY VGAGINYTTF FDNGFNDHGK EAGLSDLSLK
160 170 180 190 200
DSWGAAGQVG VDYLINRDWL VNMSVWYMDI DTTANYKLGG AQQHDSVRLD
210
PWVFMFSAGY RF
Length:212
Mass (Da):22,928
Last modified:July 19, 2005 - v1
Checksum:iFE6C1208CCF11224
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti12T → A in strain: ECOR 52 and ECOR 60. 1
Natural varianti20F → Y in strain: ECOR 46 and ECOR 50. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13583 Genomic DNA Translation: CAA31922.1
U00096 Genomic DNA Translation: AAC74338.1
AP009048 Genomic DNA Translation: BAA14788.1
U24195 Genomic DNA Translation: AAB60065.1
U24196 Genomic DNA Translation: AAB60073.1
U24197 Genomic DNA Translation: AAB60081.1
U24198 Genomic DNA Translation: AAB60089.1
U24199 Genomic DNA Translation: AAB60097.1
U24200 Genomic DNA Translation: AAB60105.1
U24201 Genomic DNA Translation: AAB60113.1
U24202 Genomic DNA Translation: AAB60121.1
U24203 Genomic DNA Translation: AAB60129.1
U24204 Genomic DNA Translation: AAB60137.1
U24205 Genomic DNA Translation: AAB60145.1
U24206 Genomic DNA Translation: AAB60153.1
PIRiS07797
T45501
RefSeqiNP_415772.1, NC_000913.3
WP_000737226.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74338; AAC74338; b1256
BAA14788; BAA14788; BAA14788
GeneIDi945128
KEGGiecj:JW1248
eco:b1256
PATRICifig|1411691.4.peg.1027

Similar proteinsi

Entry informationi

Entry nameiOMPW_ECOLI
AccessioniPrimary (citable) accession number: P0A915
Secondary accession number(s): P21364, P97217, P97220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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